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公开(公告)号：US11798701B2
公开(公告)日：2023-10-24
申请号：US17993186
申请日：2022-11-23
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , William Uhland , Brian Regna , Craig Brunkhorst
CPC分类号： G21G1/001 , A61K51/0482 , C01G3/003 , G21G1/10 , G21G4/08 , G21G2001/0094
摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
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公开(公告)号：US20220406483A1
公开(公告)日：2022-12-22
申请号：US17894874
申请日：2022-08-24
申请人： CURIUM US LLC
发明人： David Pipes , Lauren Radford , William Uhland , Brian Regna , Craig Brunkhorst
摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
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公开(公告)号：US12102696B2
公开(公告)日：2024-10-01
申请号：US17467110
申请日：2021-09-03
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , Shaun Loveless , Allan Casciola
CPC分类号： A61K51/0472 , A61K51/083
摘要： The present disclosure relates to methods to create a robust procedure capable of supplying commercial quantities of a radioactive diagnostic agent indicated for use with positron emission tomography (PET) for localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adult patients.
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公开(公告)号：US20240331889A1
公开(公告)日：2024-10-03
申请号：US18733537
申请日：2024-06-04
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , William Uhland , Brian Regna , Craig Brunkhorst
CPC分类号： G21G1/001 , A61K51/0482 , C01G3/003 , G21G1/10 , G21G4/08 , G21G2001/0094
摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
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公开(公告)号：US20230420152A1
公开(公告)日：2023-12-28
申请号：US18238951
申请日：2023-08-28
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , William Uhland , Brian Regna , Craig Brunkhorst
CPC分类号： G21G1/001 , G21G1/10 , G21G2001/0094 , A61K51/0482 , G21G4/08 , C01G3/003
摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
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公开(公告)号：US20230411032A1
公开(公告)日：2023-12-21
申请号：US18238966
申请日：2023-08-28
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , William Uhland , Brian Regna , Craig Brunkhorst
CPC分类号： G21G1/001 , G21G1/10 , C01G3/003 , A61K51/0482 , G21G4/08 , G21G2001/0094
摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
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公开(公告)号：US20230402199A1
公开(公告)日：2023-12-14
申请号：US18238972
申请日：2023-08-28
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , William Uhland , Brian Regna , Craig Brunkhorst
CPC分类号： G21G1/001 , G21G1/10 , A61K51/0482 , G21G4/08 , C01G3/003 , G21G2001/0094
摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
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公开(公告)号：US20220064015A1
公开(公告)日：2022-03-03
申请号：US17466443
申请日：2021-09-03
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , William Uhland , Brian Regna , Craig Brunkhorst
摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
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公开(公告)号：US11978569B2
公开(公告)日：2024-05-07
申请号：US18238966
申请日：2023-08-28
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , William Uhland , Brian Regna , Craig Brunkhorst
CPC分类号： G21G1/001 , A61K51/0482 , C01G3/003 , G21G1/10 , G21G4/08 , G21G2001/0094
摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
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公开(公告)号：US11972874B2
公开(公告)日：2024-04-30
申请号：US18213194
申请日：2023-06-22
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , William Uhland , Brian Regna , Craig Brunkhorst
CPC分类号： G21G1/001 , A61K51/0482 , C01G3/003 , G21G1/10 , G21G4/08 , G21G2001/0094
摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
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