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    Redox polymers for use in electrochemical-based sensors
    1.
    发明授权
    Redox polymers for use in electrochemical-based sensors 有权
    用于电化学传感器的氧化还原聚合物

    公开(公告)号：US07592151B2

    公开(公告)日：2009-09-22

    申请号：US11875681

    申请日：2007-10-19

    申请人： Zuifang Liu ,  James Jain Rodgers ,  Geoffrey Ulue

    发明人： Zuifang Liu ,  James Jain Rodgers ,  Geoffrey Ulue

    IPC分类号： C08F271/02 ,  C12Q1/54

    CPC分类号： C12Q1/006 ,  C12Q1/002 ,  C12Q1/004 ,  Y10S435/817

    摘要： A redox polymer for use in an electrochemical-based sensor includes a hydrophobic polymer backbone (e.g., a hydrophobic poly(methyl methacrylate) polymer backbone) and at least one hydrophilic polymer arm (such as a hydrophilic oligo(N-vinylpyrrolidinone) polymer arm) attached to the hydrophobic polymer backbone. The redox polymer also includes a plurality of redox mediators (e.g., ferrocene-based redox mediators) attached to the at least one hydrophilic polymer arm.

    摘要翻译： 用于基于电化学的传感器的氧化还原聚合物包括疏水性聚合物主链（例如，疏水聚（甲基丙烯酸甲酯）聚合物主链）和至少一种亲水聚合物臂（例如亲水性低聚（N-乙烯基吡咯烷酮）聚合物臂） 连接到疏水性聚合物主链上。 氧化还原聚合物还包括连接到至少一个亲水性聚合物臂上的多个氧化还原介体（例如，二茂铁基的氧化还原介体）。

    Redox polymers for use in electrochemical-based sensors
    2.
    发明授权
    Redox polymers for use in electrochemical-based sensors 有权
    用于电化学传感器的氧化还原聚合物

    公开(公告)号：US07429630B2

    公开(公告)日：2008-09-30

    申请号：US11429518

    申请日：2006-05-04

    申请人： Zuifang Liu ,  James Jain Rodgers ,  Geoffrey Lillie

    发明人： Zuifang Liu ,  James Jain Rodgers ,  Geoffrey Lillie

    IPC分类号： C08F271/02

    CPC分类号： C12Q1/006 ,  C12Q1/002 ,  C12Q1/004 ,  Y10S435/817

    摘要： A redox polymer for use in an electrochemical-based sensor includes a hydrophobic polymer backbone (e.g., a hydrophobic poly(methyl methacrylate) polymer backbone) and at least one hydrophilic polymer arm (such as a hydrophilic oligo(N-vinylpyrrolidinone) polymer arm) attached to the hydrophobic polymer backbone. The redox polymer also includes a plurality of redox mediators (e.g., ferrocene-based redox mediators) attached to the at least one hydrophilic polymer arm.

    摘要翻译： 用于基于电化学的传感器的氧化还原聚合物包括疏水性聚合物主链（例如，疏水聚（甲基丙烯酸甲酯）聚合物主链）和至少一种亲水聚合物臂（例如亲水性低聚（N-乙烯基吡咯烷酮）聚合物臂） 连接到疏水性聚合物主链上。 氧化还原聚合物还包括连接到至少一个亲水性聚合物臂上的多个氧化还原介体（例如，二茂铁基的氧化还原介体）。

    ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH GRADED ENZYMATIC REAGENT LAYER AND RELATED METHODS
    3.
    发明申请
    ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH GRADED ENZYMATIC REAGENT LAYER AND RELATED METHODS 审中-公开
    电化学分析测试条与分级酶试剂层及相关方法

    公开(公告)号：US20120199498A1

    公开(公告)日：2012-08-09

    申请号：US13021994

    申请日：2011-02-07

    申请人： Manuel Alvarez-Icaza ,  Alan McNeilage ,  Zuifang Liu ,  Damian Baskeyfield

    发明人： Manuel Alvarez-Icaza ,  Alan McNeilage ,  Zuifang Liu ,  Damian Baskeyfield

    IPC分类号： G01N27/26

    CPC分类号： G01N27/3272 ,  G01N27/3274

    摘要： An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (e.g., a whole blood sample) includes an electrically-insulating substrate, at least one working electrode disposed on the electrically-insulating substrate and a graded enzymatic reagent layer disposed on the at least one working electrode. The graded enzymatic reagent layer includes an upper reaction grade that contains an enzyme. The graded enzymatic layer also has a lower spacer grade devoid of the enzyme, the lower spacer grade disposed between the upper reaction grade and the working electrode such that the upper reaction grade is spaced equidistant from the working electrode by the lower spacer grade by a predetermined distance during use of the electrochemical-based analytical test strip. In addition, the upper reaction grade is configured and constituted such that an enzymatic reaction between the enzyme and a bodily fluid sample applied to the electrochemical-based analytical test strip is localized in the upper reaction grade and the lower spacer grade has predetermined mass transport characteristics for a component of the enzymatic reaction that cause mass transport of the component through the lower spacer grade to the working electrode to be slower than mass transport of the analyte through the bodily fluid sample to the upper reaction grade. A method for determining an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) includes applying a bodily fluid sample to such an electrochemical-based analytical test strip.

    摘要翻译： 用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）的基于电化学的分析测试条包括电绝缘基底，设置在电绝缘基底上的至少一个工作电极 以及设置在所述至少一个工作电极上的分级酶试剂层。 分级的酶试剂层包括含有酶的上反应级。 分级酶层还具有较低的不含酶的间隔物级别，下部间隔物级别位于上部反应级别和工作电极之间，使得上部反应级别通过下部间隔物等级与工作电极等距预定的预定 在使用电化学分析测试条时的距离。 此外，上反应级被配置和构成使得酶和施加到基于电化学的分析测试条上的体液样品之间的酶反应定位在上反应级中，下隔离物级具有预定的质量传递特性 对于通过下部间隔物等级将组分质量输送到工作电极的酶反应的组分比通过体液样品的分析物质量输送到上部反应级要慢。 用于测定体液样品（例如，全血样品）中的分析物（例如葡萄糖）的方法包括将体液样品施加到这种基于电化学的分析测试条上。

    Electrochemical-based sensor with a redox polymer and redox enzyme entrapped by a dialysis membrane
    7.
    发明授权
    Electrochemical-based sensor with a redox polymer and redox enzyme entrapped by a dialysis membrane 有权
    电化学传感器与氧化还原聚合物和氧化还原酶被透析膜截留

    公开(公告)号：US07572356B2

    公开(公告)日：2009-08-11

    申请号：US10931724

    申请日：2004-08-31

    申请人： James Iain Rodgers ,  Zuifang Liu ,  Geoffrey Lillie

    发明人： James Iain Rodgers ,  Zuifang Liu ,  Geoffrey Lillie

    IPC分类号： G01N27/327

    CPC分类号： C12Q1/004

    摘要： An electrochemical-based sensor includes an electrode with at least one electrode surface, a film disposed on the electrode surface, and a dialysis membrane disposed on the film. The film includes a redox enzyme and a hydrophilic redox polymer (i.e., a polymer with an attached redox mediator(s)). In addition, the dialysis membrane serves to entrap the redox polymer and redox enzyme in the vicinity of the electrode. Such entrapment is accomplished by employing a redox enzyme and a hydrophilic redox polymer of a sufficiently high molecular weight that they do not pass through the dialysis membrane.

    摘要翻译： 电化学传感器包括具有至少一个电极表面的电极，设置在电极表面上的膜和设置在膜上的透析膜。 该膜包括氧化还原酶和亲水性氧化还原聚合物（即具有附着的氧化还原介体的聚合物）。 此外，透析膜用于在电极附近截留氧化还原性聚合物和氧化还原酶。 通过使用氧化还原酶和足够高分子量的亲水性氧化还原聚合物，它们不通过透析膜来实现这种捕获。

    Ionic hydrophilic high molecular weight redox polymers for use in enzymatic electrochemical-based sensors
    8.
    发明授权
    Ionic hydrophilic high molecular weight redox polymers for use in enzymatic electrochemical-based sensors 有权
    用于酶电化学传感器的离子型亲水性高分子量氧化还原聚合物

    公开(公告)号：US07351770B2

    公开(公告)日：2008-04-01

    申请号：US10957441

    申请日：2004-09-30

    申请人： Zuifang Liu ,  James Iain Rodgers ,  Geoffrey Lillie ,  Marco Fabio Cardosi

    发明人： Zuifang Liu ,  James Iain Rodgers ,  Geoffrey Lillie ,  Marco Fabio Cardosi

    IPC分类号： C08F271/02

    CPC分类号： C12Q1/004

    摘要： Ionic hydrophilic high molecular weight redox polymers for use in enzymatic electrochemical-based sensors include a hydrophilic polymer (such as a hydrophilic polymer backbone) with ionic portions (e.g., cationic monomers incorporated in the hydrophilic polymer backbone) and a plurality of attached redox mediators. The redox mediators can be, for example, covalently attached to the hydrophilic polymer in a pendant manner. An exemplary cationic hydrophilic high molecular weight redox polymer is synthesized by co-polymerization of a hydrophilic acrylamide monomer, [2-(acryloyloxy)ethyl]trimethyl ammonium chloride and vinyl ferrocene.

    摘要翻译： 用于酶电化学传感器的离子型亲水性高分子量氧化还原聚合物包括具有离子部分的亲水性聚合物（例如亲水性聚合物主链）（例如并入亲水性聚合物主链中的阳离子单体）和多个附着的氧化还原介体。 氧化还原介体可以例如以悬挂的方式与亲水性聚合物共价连接。 通过亲水丙烯酰胺单体[2-（丙烯酰氧基）乙基]三甲基氯化铵和乙烯基二茂铁的共聚合来合成示例性的阳离子亲水性高分子量氧化还原聚合物。

    Method for manufacturing an enzymatic electrochemical-based sensor
    9.
    发明申请
    Method for manufacturing an enzymatic electrochemical-based sensor 审中-公开
    酶电化学传感器的制造方法

    公开(公告)号：US20060226007A1

    公开(公告)日：2006-10-12

    申请号：US11118894

    申请日：2005-04-28

    申请人： James Rodgers ,  Zuifang Liu ,  Alan McNeilage ,  Margaret MacLennan ,  James Moffat ,  Geoffrey Lillie ,  Michael MacDonald

    发明人： James Rodgers ,  Zuifang Liu ,  Alan McNeilage ,  Margaret MacLennan ,  James Moffat ,  Geoffrey Lillie ,  Michael MacDonald

    IPC分类号： C12Q1/00

    CPC分类号： C12Q1/004

    摘要： A method for manufacturing a portion of an enzymatic electrochemical-based sensor includes applying a water-miscible conductive ink to a substrate of an enzymatic electrochemical-based sensor. The water-miscible conductive ink includes a conductive material, an enzyme, a mediator, and a binding agent (that becomes operatively water-insoluble upon drying) formulated as a water-miscible aqueous-based dispersion. The method further includes the drying the water-miscible conductive ink to form a conductive layer on the substrate that includes an operatively water-insoluble binding agent.

    摘要翻译： 用于制造酶电化学传感器的一部分的方法包括将水混溶性导电油墨施加到酶电化学传感器的基底上。 水混溶性导电油墨包括配制为水混溶性水基分散体的导电材料，酶，介质和粘合剂（其在干燥时变得可操作地不溶于水）。 该方法还包括干燥水混溶性导电油墨以在基材上形成包含可操作的水不溶性粘合剂的导电层。