公开(公告)号：US20120259153A1

公开(公告)日：2012-10-11

申请号：US13502949

申请日：2010-10-20

Applicant: Zhuang Wang ,  Michael Edward Werner ,  James Donald Byrne ,  Ronald Chingyun Chen ,  Shrirang Shrikant Karve ,  Joseph DeSimone

Inventor： Zhuang Wang ,  Michael Edward Werner ,  James Donald Byrne ,  Ronald Chingyun Chen ,  Shrirang Shrikant Karve ,  Joseph DeSimone

IPC: A61M36/12 ,  B82Y5/00

CPC classification number: A61B17/3468 ,  A61B17/3403 ,  A61B2017/00274 ,  A61B2017/00893 ,  A61B2017/3407 ,  A61B2018/00547

Abstract: Delivery systems adapted for implementation during a brachytherapy procedure are provided. The delivery system includes a plurality of brachytherapy seeds and a plurality of spacers. Each spacer is formed of a matrix material carrying a plurality of microparticles and/or nanoparticles. The microparticles and/or nanoparticles carry an agent and are biodegradable and/or biocompatible. The brachytherapy seeds and the spacers are configured to be delivered to a target site. Associated methods are also provided.

Abstract translation: 提供适应于近距离放射治疗过程中实施的输送系统。 递送系统包括多个近距离放射治疗种子和多个间隔物。 每个间隔物由承载多个微粒和/或纳米颗粒的基质材料形成。 微粒和/或纳米颗粒携带一种试剂并且是可生物降解的和/或生物相容的。 近距离放射治疗种子和间隔物构造成被输送到目标部位。 还提供了相关的方法。

公开(公告)号：US08781841B1

公开(公告)日：2014-07-15

申请号：US13155250

申请日：2011-06-07

Applicant: Zhuang Wang

Inventor： Zhuang Wang

IPC: G10L15/00

CPC classification number: H04M3/56 ,  G10L2015/088 ,  G10L2015/225 ,  H04M3/569 ,  H04M2201/41 ,  H04M2201/42 ,  H04M2203/5054 ,  H04M2203/5081

Abstract: An example method is provided that may include receiving a first request to join a communication session; receiving voice data from a telephonic device in response to an audio prompt requesting a voice input from a dial-in user; interpreting the voice data to identify a particular name; and presenting the particular name in a graphical user interface associated with the communication session, the presentation of the particular name identifying that the dial-in user has joined the communication session.

Abstract translation: 提供了可以包括接收加入通信会话的第一请求的示例方法; 响应于从拨入用户请求语音输入的音频提示从电话设备接收语音数据; 解释语音数据以识别特定名称; 以及在与所述通信会话相关联的图形用户界面中呈现所述特定名称，所述特定名称的呈现标识所述拨入用户已加入所述通信会话。

公开(公告)号：US20150227838A1

公开(公告)日：2015-08-13

申请号：US14427677

申请日：2013-09-16

Applicant: Zhuang WANG ,  Fabian MOERCHEN ,  Dmitriy FRADKIN

Inventor： Zhuang Wang ,  Fabian Moerchen ,  Dmitriy Fradkin

IPC: G06N5/04 ,  G06N7/00 ,  G06N99/00

CPC classification number: G06N5/04 ,  G06F11/008 ,  G06N7/00 ,  G06N20/00 ,  G16H40/40

Abstract: A method of building a model for predicting failure of a machine, including parsing (41) daily machine event logs of one or more machines to extract data for a plurality of features, parsing (42) service notifications for the one or more machine to extract failure information data, creating (43) bags from the daily machine event log data and failure information data for multiple instance learning by grouping daily event log data into the bags based on a predetermined predictive interval, labeling each bag with a with a known failure as positive, and bags without known failures as negative, where a bag is a set of feature vectors and an associated label, where each feature vector is an n-tuple of features, transforming (44) the multiple instance learning bags into a standard classification task form, selecting (45) a subset of features from the plurality of features, and training (46) a failure prediction model using the selected subset of features.

Abstract translation: 一种构建用于预测机器故障的模型的方法，包括解析（41）一个或多个机器的每日机器事件日志以提取多个特征的数据，解析（42）一个或多个机器的服务通知以提取 故障信息数据，从日常机器事件日志数据创建（43）行李，并通过基于预定的预定间隔将日常事件日志数据分组到行李中来进行多个实例学习的故障信息数据，将具有已知故障的每个行李标记为 正面和没有已知故障的袋子是否定的，其中袋子是一组特征向量和相关联的标签，其中每个特征向量是n元组的特征，将多个实例学习包转换（44）到标准分类任务 形式，从所述多个特征中选择（45）特征的子集，以及使用所选择的特征子集来训练（46）故障预测模型。

公开(公告)号：US20140017165A1

公开(公告)日：2014-01-16

申请号：US13979271

申请日：2012-01-11

Applicant: Zhuang Wang ,  Michael Edward Pacold ,  Michael Edward Werner ,  Shrirang Karve

Inventor： Zhuang Wang ,  Michael Edward Pacold ,  Michael Edward Werner ,  Shrirang Karve

IPC: A61K31/366 ,  A61K47/34 ,  A61K9/16

CPC classification number: A61K31/366 ,  A61K9/16 ,  A61K9/5146 ,  A61K9/5153 ,  A61K41/0038 ,  A61K47/34 ,  A61K47/6911

Abstract: This invention relates generally to the discovery of novel nanoparticles for delivery of DNA double-stranded break (DSB) repair enzyme inhibitors such as wortmannin or wortmannin analogues. In one embodiment, these nanoparticles comprise a polylactide polyglycolide (PLGA) copolymer and a polyethylene glycol (PEG). In addition methods of treatment and methods of enhancing radiation treatments are also provided.

Abstract translation: 本发明一般涉及用于递送DNA双链断裂（DSB）修复酶抑制剂如渥曼青霉素或渥曼青霉素类似物的新型纳米颗粒的发现。 在一个实施方案中，这些纳米颗粒包含聚丙交酯聚乙交酯（PLGA）共聚物和聚乙二醇（PEG）。 另外还提​​供了治疗方法和增强放射治疗方法。

公开(公告)号：US20110027172A1

公开(公告)日：2011-02-03

申请号：US12747040

申请日：2008-12-10

Applicant: Zhuang Wang ,  Omid C. Farokhzad ,  Liangfang Zhang ,  Aleksandar Filip Radovic-Moreno ,  Frank X. Gu ,  Robert S. Langer

Inventor： Zhuang Wang ,  Omid C. Farokhzad ,  Liangfang Zhang ,  Aleksandar Filip Radovic-Moreno ,  Frank X. Gu ,  Robert S. Langer

IPC: A61K51/12 ,  A61K9/14 ,  A61K9/00 ,  A61P43/00

CPC classification number: A61K51/1255 ,  A61K31/337 ,  A61K47/6937

Abstract: The present invention provides a drug delivery system for delivery of an agent and a radiopharmaceutical agent. The drug delivery system may specifically target an organ, tissue, cells, extracellular matrix, or intracellular compartment. Typically, the drug delivery system is a particle. Pharmaceutical compositions comprising the inventive particles are also provided. The present invention provides methods of preparing and using the inventive particles and pharmaceutical compositions. The inventive particles are useful in treating and diagnosing a variety of diseases including cancer. The inventive particles are also useful in tracking particles in vivo.

Abstract translation: 本发明提供了用于递送药剂和放射性药剂的药物递送系统。 药物递送系统可以特异性地靶向器官，组织，细胞，细胞外基质或细胞内区室。 通常，药物递送系统是颗粒。 还提供了包含本发明颗粒的药物组合物。 本发明提供了制备和使用本发明的颗粒和药物组合物的方法。 本发明的颗粒可用于治疗和诊断各种疾病，包括癌症。 本发明的颗粒也可用于在体内追踪颗粒。

公开(公告)号：US20070147738A1

公开(公告)日：2007-06-28

申请号：US11609655

申请日：2006-12-12

Applicant: Xingwei Wang ,  Juncheng Xu ,  Zhuang Wang ,  Anbo Wang

Inventor： Xingwei Wang ,  Juncheng Xu ,  Zhuang Wang ,  Anbo Wang

IPC: G02B6/42 ,  G02B6/26 ,  G02B6/00

CPC classification number: G02B6/262 ,  G01N21/45 ,  G02B6/021 ,  G02B6/2551 ,  G02B6/2552

Abstract: A fiber-optic sensor includes a Fabry-Perot cavity, the length of which may be altered by deposition of a material of interest that may be deposited or captured on an end surface thereof. The sensor may also be tapered near the end surface to a tip diameter in the range of a few micrometers or a few micrometers by a variety of techniques which may be used singly or in combination. A tapered probe of such dimensions is of minimal intrusiveness in biological observations and can be used to probe sub-micron sized cells in vivo. By developing a multi-layer self-assembled film to immobilize a capture material such as a DNA sequence complementary to a DNA sequence of interest or other organic material such as proteins, antigens and/or antibodies materials of interest may be preferentially captured and immediately detected by alteration of spectral response of the fiber-optic sensor.

Abstract translation: 光纤传感器包括法布里 - 珀罗腔，其长度可以通过沉积可能在其端面上沉积或捕获的感兴趣的材料来改变。 通过单独或组合使用的各种技术，传感器也可以在端面附近锥形到尖端直径在几微米或几微米的范围内。 这种尺寸的锥形探针在生物学观察中具有最小的侵入性，并且可用于体内探测亚微米尺寸的细胞。 通过开发多层自组装膜以固定捕获材料，例如与感兴趣的DNA序列互补的DNA序列或其它有机材料如蛋白质，可以优先捕获并立即检测到蛋白质，抗原和/或抗体材料 通过改变光纤传感器的光谱响应。