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公开(公告)号：US08101733B1
公开(公告)日：2012-01-24
申请号：US11426765
申请日：2006-06-27
IPC分类号： A61K31/727 , C08B37/10
CPC分类号： A61K31/727 , C08B37/0075
摘要： Methods for analyzing mixtures of polysaccharides, for example heparin or a LMWH, using reduce end labeling are described. In general, the mixture of polysaccharides includes polysaccharides having a desired structural moiety. In some instances, one or more polysaccharides in the mixture are chemically modified prior to analysis.
摘要翻译： 描述了使用减少末端标记来分析多糖混合物的方法，例如肝素或LMWH。 通常，多糖的混合物包括具有所需结构部分的多糖。 在一些情况下，混合物中的一种或多种多糖在分析之前被化学修饰。
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公开(公告)号：US08609632B2
公开(公告)日：2013-12-17
申请号：US11805829
申请日：2007-05-24
申请人： Zachary Shriver , Mallikarjun Sundaram , Ganesh Venkataraman , Pat Oliver-Shaffer , Yiming Yao , Zainab Sirajbhai Mamuwala , Ian David Fier , Yiwei Qi , Ishan Capila , Nur Sibel Gunay , Daniela Beccati , Cuihua Liu , Corinne Bauer , Ying Li
发明人： Zachary Shriver , Mallikarjun Sundaram , Ganesh Venkataraman , Pat Oliver-Shaffer , Yiming Yao , Zainab Sirajbhai Mamuwala , Ian David Fier , Yiwei Qi , Ishan Capila , Nur Sibel Gunay , Daniela Beccati , Cuihua Liu , Corinne Bauer , Ying Li
IPC分类号： A61K31/727 , A61K31/715 , A01N43/04
CPC分类号： C08B37/0078
摘要： Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.
摘要翻译： 本文提供具有改善性能的低分子量肝素（LMWH）的制备，例如提供临床优势的性质。 提供了制备和使用这些制剂的方法以及在生产这种LMWH制剂中分析原料，加工，中间体和最终产品的方法。
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公开(公告)号：US20100305022A1
公开(公告)日：2010-12-02
申请号：US12788264
申请日：2010-05-26
申请人： Zachary Shriver , Mallikarjun Sundaram , Ganesh Venkataraman , Pat Oliver-Shaffer , Yiming Yao , Zainab Sirajbhai Mamuwala , Ian David Fier , Yiwei Qi , Ishan Capila , Nur Sibel Gunay , Daniela Beccati , Cuihua Liu , Corinne Bauer , Ying Li
发明人： Zachary Shriver , Mallikarjun Sundaram , Ganesh Venkataraman , Pat Oliver-Shaffer , Yiming Yao , Zainab Sirajbhai Mamuwala , Ian David Fier , Yiwei Qi , Ishan Capila , Nur Sibel Gunay , Daniela Beccati , Cuihua Liu , Corinne Bauer , Ying Li
IPC分类号： A61K38/00 , A61K31/727 , A61P7/02 , C12P19/04
CPC分类号： C08B37/0078
摘要： Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.
摘要翻译： 本文提供具有改善性能的低分子量肝素（LMWH）的制备，例如提供临床优势的性质。 提供了制备和使用这些制剂的方法以及在生产这种LMWH制剂中分析原料，加工，中间体和最终产品的方法。
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公开(公告)号：US20070287683A1
公开(公告)日：2007-12-13
申请号：US11805829
申请日：2007-05-24
申请人： Zachary Shriver , Mallikarjun Sundaram , Ganesh Venkataraman , Pat Oliver-Shaffer , Yiming Yao , Zainab Mamuwala , Ian Fier , Yiwei Qi , Ishan Capila , Nur Gunay , Daniela Beccati , Cuihua Liu , Corinne Bauer , Ying Li
发明人： Zachary Shriver , Mallikarjun Sundaram , Ganesh Venkataraman , Pat Oliver-Shaffer , Yiming Yao , Zainab Mamuwala , Ian Fier , Yiwei Qi , Ishan Capila , Nur Gunay , Daniela Beccati , Cuihua Liu , Corinne Bauer , Ying Li
IPC分类号： A61K31/727 , C08B37/10
CPC分类号： C08B37/0078
摘要： Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.
摘要翻译： 本文提供具有改善性能的低分子量肝素（LMWH）的制备，例如提供临床优势的性质。 提供了制备和使用这些制剂的方法以及在生产这种LMWH制剂中分析原料，加工，中间体和最终产品的方法。
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公开(公告)号：US08512969B2
公开(公告)日：2013-08-20
申请号：US13465639
申请日：2012-05-07
申请人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
发明人： Ram Sasisekharan , Ganesh Venkataraman , Zachary Shriver , Dongfang Liu , Mallikarjun Sundaram , Yiwei Qi
IPC分类号： A61K31/727
CPC分类号： G01N33/66 , A61K31/727 , C08B37/0075 , C12P19/26 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333
摘要： The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.
摘要翻译： 本发明涉及用于表征和使用多糖的方法和产品。 描述了低分子量肝素产品和使用方法。 还描述了表征包括糖胺聚糖如肝素的多糖制剂的纯度和活性的方法。
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6.发明申请DELTA 4,5 GLYCURONIDASE COMPOSITIONS AND METHODS RELATED THERETO 有权DELTA 4,5 GLYCURONIDASE组合物及其相关方法公开(公告)号：US20100129868A1
公开(公告)日：2010-05-27
申请号：US12616764
申请日：2009-11-11
申请人： James R. Myette , Zachary Shriver , Ganesh Venkataraman , Ram Sasisekharan , Maitland W. McLean
发明人： James R. Myette , Zachary Shriver , Ganesh Venkataraman , Ram Sasisekharan , Maitland W. McLean
IPC分类号： C12P21/06
CPC分类号： C12Y302/01056 , A61K38/00 , C07H21/04 , C12N9/2402 , C12Q1/34 , C12Y302/01166 , Y02A50/481
摘要： The invention relates to Δ4,5 glycuronidase, related compositions, and methods of use thereof.
摘要翻译： 本发明涉及＆amp; 4,5g糖醛酸糖苷酶，相关组合物及其使用方法。
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公开(公告)号：US07429474B2
公开(公告)日：2008-09-30
申请号：US11433228
申请日：2006-05-11
IPC分类号： C12N9/16
CPC分类号： C12N9/16 , A61K38/00 , C12P19/04 , G01N33/5041 , G01N2400/40
摘要： The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.
摘要翻译： 本发明涉及2-O硫酸酯酶及其用途。 特别地，本发明涉及编码这些分子的重组产生的2-O硫酸酯酶，功能变体和核酸分子。 本发明还提供了用于各种目的的2-O硫酸酯酶的方法，包括降解和分析样品中存在的糖胺聚糖（GAG）。 例如，2-O硫酸酯酶可用于测定样品中存在的糖胺聚糖的纯度，同一性，组成和顺序。 本发明还涉及抑制血管生成和细胞增殖的方法以及使用2-O硫酸酯酶降解产生的2- O硫酸酯酶和/或GAG片段来治疗癌症，神经变性疾病，动脉粥样硬化和微生物感染的方法。
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公开(公告)号：US07412332B1
公开(公告)日：2008-08-12
申请号：US09557997
申请日：2000-04-24
IPC分类号： G06F19/00
CPC分类号： G06F19/703 , C07K1/00 , G06F19/28 , Y10S707/99936 , Y10S707/99943
摘要： A data structure, tangibly embodied in a computer-readable medium, representing a polymer of chemical units is disclosed. The data structure includes an identifier including a plurality of fields for storing values corresponding to properties of the polymer. The polymer may, for example, be a polysaccharide and the chemical units may be saccharides. Also disclosed is a computer-implemented method for determining whether properties of a query sequence of chemical units match properties of a polymer of chemical units. The query sequence is represented by a first data structure, and the polymer is represented by a second data structure, each are tangibly embodied in a computer-readable medium, including an identifier including a plurality of bit fields for storing values corresponding to properties of the query sequence and polymer, respectively. The invention also involves a notational system referred to as Property Encoded Nomenclature.
摘要翻译： 公开了一种有形地体现在表示化学单元的聚合物的计算机可读介质中的数据结构。 数据结构包括标识符，其包括用于存储与聚合物的性质对应的值的多个场。 聚合物可以是例如多糖，化学单元可以是糖。 还公开了一种用于确定化学单元的查询序列的属性是否与化学单元的聚合物的性质匹配的计算机实现的方法。 查询序列由第一数据结构表示，并且聚合物由第二数据结构表示，每个数据结构都有形地体现在计算机可读介质中，包括包括多个位字段的标识符，用于存储对应于 查询序列和聚合物。 本发明还涉及称为属性编码术语的符号系统。
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公开(公告)号：US07247445B2
公开(公告)日：2007-07-24
申请号：US11432824
申请日：2006-05-11
CPC分类号： C12N9/16 , A61K38/00 , C12P19/04 , G01N33/5041 , G01N2400/40
摘要： The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.
摘要翻译： 本发明涉及2-O硫酸酯酶及其用途。 特别地，本发明涉及编码这些分子的重组产生的2-O硫酸酯酶，功能变体和核酸分子。 本发明还提供了用于各种目的的2-O硫酸酯酶的方法，包括降解和分析样品中存在的糖胺聚糖（GAG）。 例如，2-O硫酸酯酶可用于测定样品中存在的糖胺聚糖的纯度，同一性，组成和顺序。 本发明还涉及抑制血管生成和细胞增殖的方法以及使用2-O硫酸酯酶降解产生的2- O硫酸酯酶和/或GAG片段来治疗癌症，神经变性疾病，动脉粥样硬化和微生物感染的方法。
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公开(公告)号：US07110889B2
公开(公告)日：2006-09-19
申请号：US10760133
申请日：2004-01-16
IPC分类号： G06F19/00
CPC分类号： G06F19/703 , C07K1/00 , G06F19/28 , Y10S707/99936 , Y10S707/99943
摘要： The invention relates to methods of identifying and characterizing properties of polymers to provide information about the polymer such as the charge of the polymer, the number and types or characteristics of units of the polymer and the sequence of the polymers. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction.
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