公开(公告)号：US4877523A

公开(公告)日：1989-10-31

申请号：US326498

申请日：1989-03-20

申请人： Yoshiaki Nunogaki

发明人： Yoshiaki Nunogaki

IPC分类号： G01N30/42

CPC分类号： G01N30/42

摘要： A cassette for use in a centrifugal counter-current distribution chromatographic apparatus which comprises a motor-driven rotor supported for rotation about a shaft having at least one pocket defined therein, and at least one cassette having a tortuous separation passage defined therein with the opposite ends adapted to be connected respectively to a source of fluid samples and the outside, the fluid samles being continuously supplied to the separation passage while the rotor is driven in one direction at high speed to effect the counter-current distribution. The cassette comprises at least one flat plate member having defined therein a plurality of slots and a corresponding number of narrow grooves alternating with the slots, each of the narrow grooves being continued at one end to one slot and at the other end to the next adjacent slot, sealing plates disposed on respective side faces of the flat plate member, and metallic side plates clamped together with the flat plate member and the sealing plates disposed therebetween. The slots and narrow grooves are so defined in the flat plate member that, when the cassette is mounted on the rotor, they can be oriented radially of the rotor.

摘要翻译： 一种用于离心逆流分布色谱装置的盒子，包括一个电机驱动的转子，该转子被支承为围绕一轴转动，该转轴具有限定在其中的至少一个凹槽，以及至少一个具有曲折分离通道的盒， 适于分别连接到流体样品源和外部，流体样品被连续地供给到分离通道，同时转子以高速一个方向驱动以实现逆流分布。 盒包括至少一个平板部件，其中限定有多个槽和相应数量的与槽交替的窄槽，每个窄槽在一端连续到一个槽，另一端连续到下一个相邻 狭槽，设置在平板构件的相应侧面上的密封板以及与平板构件夹持在一起的金属侧板和设置在其间的密封板。 狭槽和窄槽在平板构件中被限定，当盒安装在转子上时，它们可以被定向在转子的径向上。

公开(公告)号：US4550417A

公开(公告)日：1985-10-29

申请号：US434487

申请日：1982-10-15

申请人： Yoshiaki Nunogaki ,  Tetsuya Kobayashi ,  Yasutaka Kosuge

发明人： Yoshiaki Nunogaki ,  Tetsuya Kobayashi ,  Yasutaka Kosuge

IPC分类号： G06M11/02

CPC分类号： G01N15/1434 ,  G06M11/02 ,  G01N2015/1006 ,  G01N2015/144 ,  G01N2015/1486

摘要： An apparatus for counting numbers of microscopic corpuscles such as blood cells, comprising an optical system, a driving mechanism, a photoelectrical convertor means and a counter means. The optical means is adapted to illuminate a sample containing the corpuscles so as to irradiate magnified images onto a charge coupled device (CCD) as the convertor means having elements lined up in a row in an X-direction perpendicular to a Y-direction in which the sample is moved by the driving mechanism whereby X-directional scanning is automatically executed by the CCD without moving the sample while Y-directional scanning is conducted with a sample holder continuously moved by said mechanism comprising a drive motor and a cooperating spring. The CCD is adapted to detect the number of corpuscle images contained in each scanning line in the X-direction and thereby to produce electric signals fed to the counter means, which comprises electronic circuits for summing up these signals in respect of Y-direction.

摘要翻译： 一种用于计数诸如血细胞的微小小体数目的装置，包括光学系统，驱动机构，光电转换装置和计数装置。 光学装置适于照亮包含小体的样本，以便将放大的图像照射到电荷耦合器件（CCD）上，因为转换器装置具有沿垂直于Y方向的X方向排成一行的元件，其中 通过驱动机构移动样品，由CCD进行X方向扫描，而不移动样品，同时通过包括驱动电动机和配合弹簧的机构连续移动的样品架进行Y方向扫描。 CCD适于检测包含在X方向上的每条扫描线中的微粒图像的数量，从而产生馈送到计数器装置的电信号，该电信号包括用于相对于Y方向求和这些信号的电子电路。

公开(公告)号：US4968428A

公开(公告)日：1990-11-06

申请号：US400054

申请日：1989-08-29

申请人： Yoshiaki Nunogaki

发明人： Yoshiaki Nunogaki

IPC分类号： G01N30/42

CPC分类号： G01N30/42 ,  B01D15/1892

摘要： A cassette for use in a centrifugal counter-current distribution chromatographic apparatus which comprises a motor-driven rotor supported for rotation about a shaft having at least one pocket defined therein, and at least one cassette having a tortuous separation passage defined therein with the opposite ends adapted to be connected respectively to a source of fluid samples and the outside, the fluid samples being continuously supplied to the separation passage while the rotor is driven in one direction at high speed to effect the counter-current distribution. The cassette comprises at least one flat plate member having defined therein a plurality of slots and a corresponding number of narrow grooves alternating with the slots, each of the narrow grooves being continued at one end to one slot and at the other end to the next adjacent slot, sealing plates disposed on respective side faces of the flat plate member, and metallic side plates clamped together with the flat plate member and the sealing plates disposed therebetween. The slots and narrow grooves are so defined in the flat plate member that, when the cassette is mounted on the rotor, they can be oriented radially of the rotor.

摘要翻译： 一种用于离心逆流分布色谱装置的盒子，包括一个电机驱动的转子，该转子被支承为围绕一轴转动，该转轴具有限定在其中的至少一个凹槽，以及至少一个具有曲折分离通道的盒， 适于分别连接到流体样品源和外部，流体样品被连续地供给到分离通道，同时转子以高速一个方向驱动以实现逆流分布。 盒包括至少一个平板部件，其中限定有多个槽和相应数量的与槽交替的窄槽，每个窄槽在一端连续到一个槽，另一端连续到下一个相邻 狭槽，设置在平板构件的相应侧面上的密封板以及与平板构件夹持在一起的金属侧板和设置在其间的密封板。 狭槽和窄槽在平板构件中被限定，当盒安装在转子上时，它们可以被定向在转子的径向上。

公开(公告)号：US4813420A

公开(公告)日：1989-03-21

申请号：US111031

申请日：1987-10-20

申请人： Yoshiaki Nunogaki

发明人： Yoshiaki Nunogaki

IPC分类号： G01N33/50 ,  G01N15/00 ,  G01N15/04 ,  G01N15/05 ,  G01N21/25 ,  G01N21/59 ,  G01N33/48

CPC分类号： G01N21/251 ,  G01N15/05 ,  G01N2015/0069 ,  G01N2015/045 ,  G01N2021/5973 ,  G01N2201/0621

摘要： A hemolysis reaction measuring device includes a hemolysis reacting member made of a light transmitting material and adapted to cause hemolysis reaction to take place therein, a light source supported so as to be able to project light toward a side portion of the hemolysis reacting member, and a light receiving member which allows the light emitted from the light source and passing through the hemolysis reacting member to be incident upon it so as to measure light absorbance of a liquid within the hemolysis reacting member based on the intensity of the incident light. The light source is formed by a light emitting diode.

摘要翻译： 溶血反应测定装置包括由透光性材料制成并适于引起溶血反应的溶血反应构件，被支撑为能够朝向溶血反应构件的侧部投射光的光源，以及 允许从光源发射并通过溶血反应构件的光入射到其上的光接收构件，以便根据入射光的强度来测量溶血反应构件内的液体的吸光度。 光源由发光二极管形成。

公开(公告)号：US4858961A

公开(公告)日：1989-08-22

申请号：US85860

申请日：1987-08-14

申请人： Yoshiaki Nunogaki

发明人： Yoshiaki Nunogaki

IPC分类号： F16L27/08 ,  F16L37/00 ,  F16L39/04

CPC分类号： F16L39/04

摘要： An improved rotary joint including first, second and third joint portions, and so arranged to connect two flow passages to each other respectively at the rotary unit side and stationary side so as to continuously effect, for example, centrifugal counter-current distribution work.

摘要翻译： 一种改进的旋转接头，包括第一，第二和第三接头部分，并且设置成在旋转单元侧和固定侧分别连接两个流动通道，以便连续地实现例如离心式逆流分配工作。

公开(公告)号：US4178152A

公开(公告)日：1979-12-11

申请号：US880159

申请日：1978-02-22

申请人： Yoshiaki Nunogaki

发明人： Yoshiaki Nunogaki

IPC分类号： G01N33/50 ,  G01N33/16

CPC分类号： G01N33/50 ,  Y10T436/25375

摘要： A method of and an appliance for use in testing the osmotic fragility of blood cells by the use of the CPC method involving a coil column containing an aqueous solution of a salt mixed with one or both of a viscosity modifier and a hemolysis promotor. This coil column, after the blood to be tested has been injected, is centrifuged while undergoing a planetary motion to cause the blood cells to undergo hemolysis. After this hemolysis, a hematological pattern is developed in the coil column, the position of the coil column at which such hematological pattern has been developed being indicative of the osmotic fragility of the subject blood.

摘要翻译： 一种用于通过使用包含与粘度调节剂和溶血促进剂中的一种或两者混合的盐的水溶液的线圈柱的CPC法来测试血细胞的渗透脆性的方法和器具。 待测血液注射后，将该血管柱离心分离，同时进行行星运动，使血细胞发生溶血。 在这种溶血之后，在线圈柱中形成血液图案，已经开发了这种血液图案的线圈柱的位置指示了主体血液的渗透脆性。