公开(公告)号：US10941136B2

公开(公告)日：2021-03-09

申请号：US16096712

申请日：2017-04-26

申请人： YUHAN CORPORATION

发明人： Young-Hwan Kim ,  Tae-Dong Han ,  Dong-Hoon Kim ,  Eun-Hye Jung ,  Su-Bin Choi ,  Eui-Chul Lee ,  Won-Ee Chong ,  Jin-Hwi Park ,  Jun-Chul Park ,  Ho-Woong Kang ,  Ji-Yeong Gal ,  Chan-Sun Park ,  Jong-Gyun Kim ,  Su-Youn Nam

IPC分类号： C07D239/91 ,  C07D403/14 ,  C07D217/24 ,  A61K31/51 ,  A61K31/506 ,  C07D403/12

摘要： The present invention provides a quinazoline derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof. The quinazoline derivative or its pharmaceutically acceptable salt has a selective inhibitory activity against the phosphatidylinositol 3-kinase delta subunit, and therefore can be usefully applied for preventing or treating cancer, along with avoiding side effects such as lymphopenia-associated inflammatory responses.

公开(公告)号：US09663495B2

公开(公告)日：2017-05-30

申请号：US14786837

申请日：2014-04-22

申请人： YUHAN CORPORATION

发明人： Tae-Dong Han ,  Eun-Hye Jung ,  Chung-Ho Yi ,  Byoung-Moon Lee ,  Yoo-Hoi Park ,  Dong-Hoon Lee ,  Jong-Ho Kang ,  Na-Yeon Yang ,  Do-Hoon Kim ,  Kwan-Hoon Hyun ,  Kaap-Joo Park ,  Chun-Ho Lee ,  Su-Youn Nam

IPC分类号： C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07C403/10 ,  C07C403/14 ,  C07D405/04 ,  C07D405/06 ,  C07D413/14 ,  C07D249/12 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14

CPC分类号： C07D401/14 ,  C07D249/12 ,  C07D401/10 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/04 ,  C07D405/06 ,  C07D405/14 ,  C07D413/14

摘要： Provided is a triazolone derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The triazolone derivative or its pharmaceutically acceptable salt can effectively activate GPR119; and therefore be usefully applied for preventing or treating diabetes mellitus.

公开(公告)号：US09376420B2

公开(公告)日：2016-06-28

申请号：US14438299

申请日：2013-10-23

申请人： YUHAN CORPORATION

发明人： Chan-Sun Park ,  Young-Hwan Kim ,  Gyu-Jin Lee ,  Youn Hur ,  Eun-Hye Jung ,  Hee-Jae Tak ,  Seung-Yub Shin ,  Ho-Jin Lee ,  Chun-Ho Lee ,  Koo-Yeon Lee

IPC分类号： C07D403/04 ,  C07D231/06 ,  C07D401/10 ,  C07D403/10 ,  C07D401/06

CPC分类号： C07D403/10 ,  C07D231/06 ,  C07D401/06 ,  C07D401/10 ,  C07D403/04

摘要： The present invention provides a 4,5-dihydro-1H-pyrazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The 4,5-dihydro-1H-pyrazole derivative or its pharmaceutically acceptable salt effectively increases the LXR transcriptional activity, and therefore can be usefully applied for preventing or treating a dysfunction in cholesterol metabolism, such as cholesterol gallstone, hyperlipidemia, or coronary atherosclerosis.

摘要翻译： 本发明提供了4,5-二氢-1H-吡唑衍生物或其药学上可接受的盐，其制备方法和包含其的药物组合物。 4,5-二氢-1H-吡唑衍生物或其药学上可接受的盐有效地增加LXR转录活性，因此可用于预防或治疗胆固醇代谢功能障碍，例如胆固醇胆结石，高脂血症或冠状动脉粥样硬化。

公开(公告)号：US20150291563A1

公开(公告)日：2015-10-15

申请号：US14438299

申请日：2013-10-23

申请人： YUHAN CORPORATION

发明人： Chan-Sun Park ,  Young-Hwan Kim ,  Gyu-Jin Lee ,  Youn Hur ,  Eun-Hye Jung ,  Hee-Jae Tak ,  Seung-Yub Shin ,  Ho-Jin Lee ,  Chun-Ho Lee ,  Koo-Yeon Lee

IPC分类号： C07D403/10 ,  C07D401/10 ,  C07D231/06 ,  C07D403/04

CPC分类号： C07D403/10 ,  C07D231/06 ,  C07D401/06 ,  C07D401/10 ,  C07D403/04

摘要： The present invention provides a 4,5-dihydro-1H-pyrazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The 4,5-dihydro-1H-pyrazole derivative or its pharmaceutically acceptable salt effectively increases the LXR transcriptional activity, and therefore can be usefully applied for preventing or treating a dysfunction in cholesterol metabolism, such as cholesterol gallstone, hyperlipidemia, or coronary atherosclerosis.

摘要翻译： 本发明提供了4,5-二氢-1H-吡唑衍生物或其药学上可接受的盐，其制备方法和包含其的药物组合物。 4,5-二氢-1H-吡唑衍生物或其药学上可接受的盐有效地增加LXR转录活性，因此可用于预防或治疗胆固醇代谢功能障碍，例如胆固醇胆结石，高脂血症或冠状动脉粥样硬化。