公开(公告)号：US09376420B2

公开(公告)日：2016-06-28

申请号：US14438299

申请日：2013-10-23

Applicant: YUHAN CORPORATION

Inventor： Chan-Sun Park ,  Young-Hwan Kim ,  Gyu-Jin Lee ,  Youn Hur ,  Eun-Hye Jung ,  Hee-Jae Tak ,  Seung-Yub Shin ,  Ho-Jin Lee ,  Chun-Ho Lee ,  Koo-Yeon Lee

IPC: C07D403/04 ,  C07D231/06 ,  C07D401/10 ,  C07D403/10 ,  C07D401/06

CPC classification number: C07D403/10 ,  C07D231/06 ,  C07D401/06 ,  C07D401/10 ,  C07D403/04

Abstract: The present invention provides a 4,5-dihydro-1H-pyrazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The 4,5-dihydro-1H-pyrazole derivative or its pharmaceutically acceptable salt effectively increases the LXR transcriptional activity, and therefore can be usefully applied for preventing or treating a dysfunction in cholesterol metabolism, such as cholesterol gallstone, hyperlipidemia, or coronary atherosclerosis.

Abstract translation: 本发明提供了4,5-二氢-1H-吡唑衍生物或其药学上可接受的盐，其制备方法和包含其的药物组合物。 4,5-二氢-1H-吡唑衍生物或其药学上可接受的盐有效地增加LXR转录活性，因此可用于预防或治疗胆固醇代谢功能障碍，例如胆固醇胆结石，高脂血症或冠状动脉粥样硬化。

公开(公告)号：US20150291563A1

公开(公告)日：2015-10-15

申请号：US14438299

申请日：2013-10-23

Applicant: YUHAN CORPORATION

Inventor： Chan-Sun Park ,  Young-Hwan Kim ,  Gyu-Jin Lee ,  Youn Hur ,  Eun-Hye Jung ,  Hee-Jae Tak ,  Seung-Yub Shin ,  Ho-Jin Lee ,  Chun-Ho Lee ,  Koo-Yeon Lee

IPC: C07D403/10 ,  C07D401/10 ,  C07D231/06 ,  C07D403/04

CPC classification number: C07D403/10 ,  C07D231/06 ,  C07D401/06 ,  C07D401/10 ,  C07D403/04

Abstract: The present invention provides a 4,5-dihydro-1H-pyrazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The 4,5-dihydro-1H-pyrazole derivative or its pharmaceutically acceptable salt effectively increases the LXR transcriptional activity, and therefore can be usefully applied for preventing or treating a dysfunction in cholesterol metabolism, such as cholesterol gallstone, hyperlipidemia, or coronary atherosclerosis.

Abstract translation: 本发明提供了4,5-二氢-1H-吡唑衍生物或其药学上可接受的盐，其制备方法和包含其的药物组合物。 4,5-二氢-1H-吡唑衍生物或其药学上可接受的盐有效地增加LXR转录活性，因此可用于预防或治疗胆固醇代谢功能障碍，例如胆固醇胆结石，高脂血症或冠状动脉粥样硬化。