-
公开(公告)号：US10184000B2
公开(公告)日：2019-01-22
申请号：US15167832
申请日：2016-05-27
Applicant: Xencor, Inc.
Inventor： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Desjarlais , Stephen K. Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
IPC: C07H21/04 , C12N15/00 , C12N5/02 , C12P21/06 , C07K16/00 , C07K16/28 , C07K16/32 , A61K39/395 , C07K16/22 , C07K16/42 , C40B30/02 , G06F19/16 , G06F19/22 , C12P21/00 , G06F19/12 , A61K39/00
Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
-
公开(公告)号：US20180208668A1
公开(公告)日：2018-07-26
申请号：US15839741
申请日：2017-12-12
Applicant: Xencor, Inc.
Inventor： Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes , Jost Vielmetter
CPC classification number: C07K16/2893 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/64 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92 , C07K2317/94
Abstract: The present invention relates to Fc variants having decreased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
-
公开(公告)号：US09714282B2
公开(公告)日：2017-07-25
申请号：US14286825
申请日：2014-05-23
Applicant: Xencor, Inc.
Inventor： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John R. Desjarlais , Stephen K. Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
IPC: C07K16/00 , C12P21/08 , C07H21/02 , C07H21/04 , C12P21/06 , C12P21/04 , C12N5/00 , C12N1/20 , C07K16/28 , C07K16/32 , C07K1/00
CPC classification number: C07K16/00 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/32 , C07K2317/33 , C07K2317/41 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/92
Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
-
公开(公告)号：US20170166655A1
公开(公告)日：2017-06-15
申请号：US15406588
申请日：2017-01-13
Applicant: Xencor, Inc.
Inventor： Gregory Alan Lazar , Bassil Dahiyat , Wei Dang , John Desjarlais , Sher Bahadur Karki , Omid Vafa , Robert Hayes , Jost Vielmetter
CPC classification number: C07K16/32 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/30 , C07K2317/41 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/92
Abstract: The present invention relates to Fc variants with optimized Fc ligand binding properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized Fc ligand binding properties, and methods for using same.
-
公开(公告)号：US20160347825A1
公开(公告)日：2016-12-01
申请号：US15167832
申请日：2016-05-27
Applicant: Xencor, Inc.
Inventor： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Desjarlais , Stephen K. Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
CPC classification number: C07K16/283 , A61K39/395 , A61K39/3955 , A61K39/39566 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12P21/005 , C40B30/02 , G06F19/12 , G06F19/16 , G06F19/22
Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
-
Patent Agency Ranking
公开(公告)号：US20150031862A1
公开(公告)日：2015-01-29
申请号：US14507783
申请日：2014-10-06
Applicant: Xencor, Inc.
Inventor： Gregory LAZAR , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes , Jost Vielmetter
IPC: C07K16/18
CPC classification number: C07K16/2893 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/64 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92 , C07K2317/94
Abstract: The present invention relates to Fc variants having decreased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
-
公开(公告)号：US20150010543A1
公开(公告)日：2015-01-08
申请号：US14326373
申请日：2014-07-08
Applicant: Xencor, Inc.
Inventor： Gregory Lazar , Wei Dang , John Desjarlais , Sher Karki , Omid Vafa , Robert Hayes , Jost Vielmetter
IPC: C07K16/28
CPC classification number: C07K16/2893 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/64 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92 , C07K2317/94
Abstract: The present invention relates to Fc variants having decreased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
Abstract translation: 本发明涉及对FcγRIIb具有降低的亲和力的Fc变体，其产生方法，包含优化的Fc变体的Fc多肽，以及使用优化的Fc变体的方法。
-
公开(公告)号：US08809503B2
公开(公告)日：2014-08-19
申请号：US13898386
申请日：2013-05-20
Applicant: Xencor, Inc.
Inventor： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Desjarlais , Stephen K. Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
CPC classification number: C07K16/283 , A61K39/395 , A61K39/3955 , A61K39/39566 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12P21/005 , C40B30/02 , G06F19/12 , G06F19/16 , G06F19/22
Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
Abstract translation: 本发明涉及优化的Fc变体，其产生方法，以及包含优化的Fc变体的抗体和Fc融合体。
-
公开(公告)号：US20190071512A1
公开(公告)日：2019-03-07
申请号：US16138605
申请日：2018-09-21
Applicant: Xencor, Inc.
Inventor： Gregory Lazar , Wei Dang , John Desjarlais , Sher Bahadur Karki , Omid Vafa , Robert Hayes
CPC classification number: C07K16/2893 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/64 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92 , C07K2317/94
Abstract: The present invention relates to Fc variants having increased affinity for FcγRIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
-
公开(公告)号：US20180360981A1
公开(公告)日：2018-12-20
申请号：US15883006
申请日：2018-01-29
Applicant: Xencor, Inc.
Inventor： Gregory Alan Lazar , Bassil Dahiyat , Wei Dang , John Desjarlais , Sher Bahadur Karki , Omid Vafa , Robert Hayes , Jost Vielmetter
Abstract: The present invention relates to Fc variants with optimized Fc ligand binding properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized Fc ligand binding properties, and methods for using same.
-
-
-
-
-
-
-
-
-
Search Results
34
records
(took 0.075 seconds)
