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![Novel substituted 1H-pyrrolo[2,3-b]pyridines and preparation thereof](/abs-image/US/2006/06/15/US20060128661A1/abs.jpg.150x150.jpg)
1.发明申请公开(公告)号：US20060128661A1
公开(公告)日：2006-06-15
申请号：US11298437
申请日：2005-12-09
IPC分类号： A61K31/695 , C07F7/02 , C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： The invention relates to novel substituted 1H-pyrrolo[2,3-b]pyridines of the general formula (I) to processes for their preparation and to intermediates therefor.
摘要翻译： 本发明涉及通式（I）的新的取代的1H-吡咯并[2,3-b]吡啶，其制备方法及其中间体。
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![Substituted 1H-pyrrolo[2,3-b]pyridines and preparation thereof](/abs-image/US/2009/05/05/US07528146B2/abs.jpg.150x150.jpg)
公开(公告)号：US07528146B2
公开(公告)日：2009-05-05
申请号：US11298437
申请日：2005-12-09
IPC分类号： C07D471/02 , A61K31/4353
CPC分类号： C07D471/04
摘要： The invention relates to novel substituted 1H-pyrrolo[2,3-b]pyridines of the general formula (I) to processes for their preparation and to intermediates therefor.
摘要翻译： 本发明涉及通式（I）的新的取代的1H-吡咯并[2,3-b]吡啶，其制备方法及其中间体。
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公开(公告)号：US09676766B2
公开(公告)日：2017-06-13
申请号：US13512701
申请日：2010-11-17
申请人： Volker Schulze , Marcus Koppitz , Dirk Kosemund , Hartmut Schirok , Benjamin Bader , Philip Lienau , Antje Margret Wengner , Hans Briem , Simon Holton , Gerhard Siemeister , Stefan Prechtl , Ulf Bömer
发明人： Volker Schulze , Marcus Koppitz , Dirk Kosemund , Hartmut Schirok , Benjamin Bader , Philip Lienau , Antje Margret Wengner , Hans Briem , Simon Holton , Gerhard Siemeister , Stefan Prechtl , Ulf Bömer
IPC分类号： A61K31/437 , A61K31/5377 , C07D491/08 , C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , A61K31/5377 , A61K2300/00
摘要： The present invention relates to triazolopyridine compounds of general formula (I) which are Monopolar Spindle 1 kinase (Mps-1 or TTK) inhibitors: Formula (I), in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis proliferative of diseases, as well as to intermediate compounds useful in the preparation of said compounds.
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公开(公告)号：US20130156756A1
公开(公告)日：2013-06-20
申请号：US13704859
申请日：2011-06-14
申请人： Volker Schulze , Dirk Kosemund , Hartmut Schirok , Benjamin Bader , Philip Lienau , Antje Margret Wengner , Hans Briem , Simon Holton , Gerhard Siemeister , Stefan Prechtl , Marcus Koppitz , Detlef Stöckigt , Olaf Prien
发明人： Volker Schulze , Dirk Kosemund , Hartmut Schirok , Benjamin Bader , Philip Lienau , Antje Margret Wengner , Hans Briem , Simon Holton , Gerhard Siemeister , Stefan Prechtl , Marcus Koppitz , Detlef Stöckigt , Olaf Prien
IPC分类号： A61K31/437 , A61K31/5377 , A61K31/496 , A61K31/444 , C07D491/08 , C07D491/107 , A61K31/541 , A61K31/4545 , A61K31/337 , A61K31/427 , A61K31/428 , A61K31/167 , A61K31/565 , A61K31/277 , A61K33/24 , A61K31/282 , A61K39/395 , A61K38/14 , A61K31/704 , A61K31/513 , A61K31/675 , A61K31/7048 , A61K31/69 , C07D471/04
CPC分类号： A61K31/437 , A61K31/167 , A61K31/277 , A61K31/282 , A61K31/337 , A61K31/427 , A61K31/428 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/513 , A61K31/5377 , A61K31/541 , A61K31/565 , A61K31/675 , A61K31/69 , A61K31/704 , A61K31/7048 , A61K33/24 , A61K38/14 , A61K39/395 , A61K45/06 , C07D471/04 , C07D491/08 , C07D491/107 , C07D519/00 , A61K2300/00
摘要： The present invention relates to substituted triazolopyridine compounds of general formula (I): in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease of uncontrolled cell growth, proliferation and/or survival as well as to the use of intermediate compounds for the preparation of said compounds.
摘要翻译： 本发明涉及通式（I）的取代三唑并吡啶化合物：其中R1，R2，R3，R4和R5如说明书和权利要求书中所述，涉及制备所述化合物的方法，药物组合物和组合 包括所述化合物，用于制备用于治疗或预防不受控制的细胞生长，增殖和/或存活的疾病的药物组合物以及使用中间体化合物来制备所述化合物的用途。
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公开(公告)号：US20110245273A1
公开(公告)日：2011-10-06
申请号：US13133383
申请日：2009-12-08
申请人： Hartmut Schirok , Nils Griebenow , Chantal Fürstner , Joachim Mittendorf , Johannes-Peter Stasch , Frank Wunder , Stefan Heitmeier
发明人： Hartmut Schirok , Nils Griebenow , Chantal Fürstner , Joachim Mittendorf , Johannes-Peter Stasch , Frank Wunder , Stefan Heitmeier
IPC分类号： A61K31/506 , C07D487/04 , A61P9/04 , A61P9/10 , A61P9/12 , A61P7/02
CPC分类号： C07D471/04
摘要： The present application relates to novel aliphatically substituted pyrazolopyridines, to processes for their preparation, to their use, alone or in combination, for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型脂族取代的吡唑并吡啶，其制备方法，单独或组合用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途 ，特别是用于治疗和/或预防心血管疾病。
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6.发明申请NOVEL AZA-BICYCLIC COMPOUNDS AND THEIR USE AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE 失效新型AZA-BICYCLIC化合物及其作为可溶性葡萄糖环化酶的刺激剂公开(公告)号：US20110038857A1
公开(公告)日：2011-02-17
申请号：US12515211
申请日：2007-11-14
IPC分类号： A61K39/395 , C07D251/00 , A61K31/53 , A61K33/08 , A61K31/60 , A61P9/10 , A61P9/12 , A61P9/00
CPC分类号： C07D487/04
摘要： The present application relates to novel azabicyclic compounds, processes for their preparation, their use alone or in combinations for the treatment and/or prevention of diseases, and their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的氮杂双环化合物，其制备方法，它们单独使用或组合用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病特别是用于治疗的药物的用途 和/或预防心血管疾病。
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公开(公告)号：US09555022B2
公开(公告)日：2017-01-31
申请号：US13704859
申请日：2011-06-14
申请人： Volker Schulze , Dirk Kosemund , Hartmut Schirok , Benjamin Bader , Philip Lienau , Antje Margret Wengner , Hans Briem , Simon Holton , Gerhard Siemeister , Stefan Prechtl , Marcus Koppitz , Detlef Stöckigt , Olaf Prien
发明人： Volker Schulze , Dirk Kosemund , Hartmut Schirok , Benjamin Bader , Philip Lienau , Antje Margret Wengner , Hans Briem , Simon Holton , Gerhard Siemeister , Stefan Prechtl , Marcus Koppitz , Detlef Stöckigt , Olaf Prien
IPC分类号： C07D513/02 , C07D515/02 , C07D249/08 , A61K31/44 , A61K31/437 , A61K45/06 , C07D471/04 , C07D519/00 , A61K31/167 , A61K31/277 , A61K31/282 , A61K31/337 , A61K31/427 , A61K31/428 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/513 , A61K31/5377 , A61K31/541 , A61K31/565 , A61K31/675 , A61K31/69 , A61K31/704 , A61K31/7048 , A61K33/24 , A61K38/14 , A61K39/395 , C07D491/08 , C07D491/107
CPC分类号： A61K31/437 , A61K31/167 , A61K31/277 , A61K31/282 , A61K31/337 , A61K31/427 , A61K31/428 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/513 , A61K31/5377 , A61K31/541 , A61K31/565 , A61K31/675 , A61K31/69 , A61K31/704 , A61K31/7048 , A61K33/24 , A61K38/14 , A61K39/395 , A61K45/06 , C07D471/04 , C07D491/08 , C07D491/107 , C07D519/00 , A61K2300/00
摘要： The present invention relates to substituted triazolopyridine compounds of general formula (I): in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease of uncontrolled cell growth, proliferation and/or survival as well as to the use of intermediate compounds for the preparation of said compounds.
摘要翻译： 本发明涉及通式（I）的取代三唑并吡啶化合物：其中R1，R2，R3，R4和R5如说明书和权利要求书中所述，涉及制备所述化合物的方法，药物组合物和组合 包括所述化合物，用于制备用于治疗或预防不受控制的细胞生长，增殖和/或存活的疾病的药物组合物以及使用中间体化合物来制备所述化合物的用途。
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公开(公告)号：US08524722B2
公开(公告)日：2013-09-03
申请号：US12678288
申请日：2008-09-02
申请人： Hartmut Schirok , Ying Li-Sommer , Michael Brands , Mario Lobell , Adrian Tersteegen , Herbert Himmel , Karl-Heinz Schlemmer , Dieter Lang , Kirstin Petersen , Matthias Renz , Dominik Mumberg , Jens Hoffmann , Gerhard Siemeister , Ulf Bömer
发明人： Hartmut Schirok , Ying Li-Sommer , Michael Brands , Mario Lobell , Adrian Tersteegen , Herbert Himmel , Karl-Heinz Schlemmer , Dieter Lang , Kirstin Petersen , Matthias Renz , Dominik Mumberg , Jens Hoffmann , Gerhard Siemeister , Ulf Bömer
IPC分类号： A01N43/54 , A01N43/40 , A61K31/505 , A61K31/445 , C07D239/00 , C07D471/00 , C07D491/00 , C07D401/00 , C07D405/00 , C07D409/00
CPC分类号： C07D495/14 , C07D491/147 , C07D519/00
摘要： This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly cancer.
摘要翻译： 本发明涉及新化合物及其制备方法，治疗疾病，特别是癌症的方法，包括给药所述化合物，以及制备用于治疗或预防病症，特别是癌症的药物组合物的方法。
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9.发明申请3-Tetrazolyl Indazoles, 3-Tetrazolyl Pyrazolopyridines, and use Thereof 审中-公开3-四唑基吲唑，3-四唑基吡唑并吡啶，及其用途公开(公告)号：US20100113507A1
公开(公告)日：2010-05-06
申请号：US12299906
申请日：2007-04-30
申请人： Chantal Fürstner , Hartmut Schirok , Nils Griebenow , Joachim Mittendorf , Johannes-Peter Stasch , Frank Wunder
发明人： Chantal Fürstner , Hartmut Schirok , Nils Griebenow , Joachim Mittendorf , Johannes-Peter Stasch , Frank Wunder
IPC分类号： A61K31/437 , A61P9/00 , A61P11/00 , A61P25/28 , A61P25/16 , A61P29/00 , C07D471/04
CPC分类号： C07D405/14 , C07D403/04 , C07D409/14 , C07D471/04
摘要： The present application relates to novel 3-tetrazolylindazole and 3-tetrazolylpyrazolo[3,4-b]-pyridine derivatives, processes for their preparation, their use alone or in combination for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的3-四唑基吲唑和3-四唑基吡唑并[3,4-b] - 吡啶衍生物，其制备方法，它们单独使用或组合用于治疗和/或预防疾病及其用于生产 用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。
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10.发明申请公开(公告)号：US20080139595A1
公开(公告)日：2008-06-12
申请号：US11547975
申请日：2005-03-30
申请人： Hartmut Schirok , Martin Radtke , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Mark Jean Gnoth , Klaus Munter , Dieter Lang , Santiago Figueroa Perez , Michael Thutewohl , Samir Bennabi , Heimo Ehmke
发明人： Hartmut Schirok , Martin Radtke , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Mark Jean Gnoth , Klaus Munter , Dieter Lang , Santiago Figueroa Perez , Michael Thutewohl , Samir Bennabi , Heimo Ehmke
IPC分类号： C07D487/04 , A61K31/506 , A61P9/00
CPC分类号： C07D471/04
摘要： The invention relates to hetaryloxy-substituted phenylaminopyrimidines, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.
摘要翻译： 本发明涉及苯甲酰氧基取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防人和动物疾病，特别是心血管疾病的药物。
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