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1.发明授权Method for protecting and treating at least one muscarinic receptor from dysfunction resulting from free radical damage 失效用于从由自由基损伤引起的功能障碍中保护和治疗至少一种毒蕈碱受体的方法公开(公告)号：US08765711B2
公开(公告)日：2014-07-01
申请号：US13109756
申请日：2011-05-17
CPC分类号： A61K31/6615 , A61K31/352 , A61K31/409 , A61K31/66 , A61K31/661 , A61K31/662 , A61K31/663 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7084 , A61K31/7105 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for enhancing cellular function through protection of a tissue components such receptors, proteins, lipids, nucleic acids, carbohydrates, hormones, vitamins, and cofactors, by administering pyrophosphate analogs or related compounds.
摘要翻译： 通过施用焦磷酸酯类似物或相关化合物，通过保护组织成分如受体，蛋白质，脂质，核酸，碳水化合物，激素，维生素和辅因子来增强细胞功能的方法和组合物。
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2.发明授权Methods and compositions for enhancing cellular function through protection of tissue components 失效通过保护组织成分增强细胞功能的方法和组合物公开(公告)号：US07084126B1
公开(公告)日：2006-08-01
申请号：US09844450
申请日：2001-04-27
IPC分类号： A01N43/04 , A01N57/00 , A61K31/70 , A61K31/675
CPC分类号： A61K31/6615 , A61K31/352 , A61K31/409 , A61K31/66 , A61K31/661 , A61K31/662 , A61K31/663 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7084 , A61K31/7105 , A61K45/06 , A61K2300/00
摘要： Methods and composisions for enhancing cellular function through protection of a tissue components such receptors, proteins, lipids, nucleic acids, carbohydrates, hormones, vitamins, and cofactors, by administering pyrophosphate analogs or related compounds.
摘要翻译： 通过施用焦磷酸酯类似物或相关化合物，通过保护组织成分如受体，蛋白质，脂质，核酸，碳水化合物，激素，维生素和辅因子来增强细胞功能的方法和组合物。
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3.发明授权Methods and compositions for protecting and treating muscarinic receptors by administering a pyrophosphate analog to a subject exposed to bacterial, fungal, viral, prion or algal infection 失效通过向暴露于细菌，真菌，病毒，朊病毒或藻类感染的受试者施用焦磷酸类似物来保护和治疗毒蕈碱受体的方法和组合物公开(公告)号：US08771681B2
公开(公告)日：2014-07-08
申请号：US11220223
申请日：2005-09-06
IPC分类号： A61K38/44 , A61K31/70 , A61K31/66 , A61K31/7105 , A61K31/708 , A61K45/06 , A61K31/662 , A61K31/661 , A61K31/409 , A61K31/663 , A61K31/6615 , A61K31/7072 , A61K31/352 , A61K31/7076 , A61K31/7084
CPC分类号： A61K31/6615 , A61K31/352 , A61K31/409 , A61K31/66 , A61K31/661 , A61K31/662 , A61K31/663 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7084 , A61K31/7105 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for protecting and treating a muscarinic receptor in an animal or plant from bacterial, fungal, algo or algae infections through administration of at least one pyrophosphate analog.
摘要翻译： 通过施用至少一种焦磷酸酯类似物来保护和处理动物或植物中的毒蕈碱受体的方法和组合物，其来自细菌，真菌，藻类或藻类感染。
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4.发明申请METHOD FOR PROTECTING AND TREATING AT LEAST ONE MUSCARINIC RECEPTOR FROM DYSFUNCTION RESULTING FROM FREE RADICAL DAMAGE 失效用于保护和治疗至少一种药物受体免受自由基损伤影响的功能的方法公开(公告)号：US20110236365A1
公开(公告)日：2011-09-29
申请号：US13109756
申请日：2011-05-17
IPC分类号： A61K31/663 , A61K38/44 , A61K31/7088 , A61K38/16 , A61K38/17 , A61P25/00 , A61P9/00 , A61P35/00 , A61P39/06 , A61P39/00
CPC分类号： A61K31/6615 , A61K31/352 , A61K31/409 , A61K31/66 , A61K31/661 , A61K31/662 , A61K31/663 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7084 , A61K31/7105 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for enhancing cellular function through protection of a tissue components such receptors, proteins, lipids, nucleic acids, carbohydrates, hormones, vitamins, and cofactors, by administering pyrophosphate analogs or related compounds.
摘要翻译： 通过施用焦磷酸酯类似物或相关化合物，通过保护组织成分如受体，蛋白质，脂质，核酸，碳水化合物，激素，维生素和辅因子来增强细胞功能的方法和组合物。
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5.发明授权Methods and compositions for protecting and treating muscarinic receptors through administration of at least one protective agent 有权通过施用至少一种保护剂来保护和治疗毒蕈碱受体的方法和组合物公开(公告)号：US07786166B2
公开(公告)日：2010-08-31
申请号：US11220116
申请日：2005-09-06
IPC分类号： A61K31/35
CPC分类号： A61K31/6615 , A61K31/352 , A61K31/409 , A61K31/66 , A61K31/661 , A61K31/662 , A61K31/663 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7084 , A61K31/7105 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for protecting muscarinic receptor(s) in a subject by administering at least one protective agent alone, in combination with other protective agents, or in combination with at least one neurologic agent.
摘要翻译： 通过单独施用至少一种保护剂，与其它保护剂组合或与至少一种神经病学剂组合来保护受试者中毒蕈碱受体的方法和组合物。
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6.发明授权Methods and compositions for protecting or treating muscarinic receptors through administration of pyrophosphate analog in subjects exposed to toxic or carcinogenic metals or metal ions 失效通过在暴露于有毒或致癌金属或金属离子的受试者中施用焦磷酸酯类似物来保护或治疗毒蕈碱受体的方法和组合物公开(公告)号：US08772263B2
公开(公告)日：2014-07-08
申请号：US11220115
申请日：2005-09-06
CPC分类号： A61K31/6615 , A61K31/352 , A61K31/409 , A61K31/66 , A61K31/661 , A61K31/662 , A61K31/663 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7084 , A61K31/7105 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for protecting muscarinic receptor(s) in a subject from at least one carcinogenic or toxic metal by administration of a pyrophosphate analog. Methods and compositions for preventing at least one disease induced or caused by metals compromising the function of muscarinic receptors in a subject by administration of a pyrophosphate analog. Methods and compositions for reducing toxic action of metal ions and for reducing poisoning by metals by administering a pyrophosphate analog.
摘要翻译： 通过给予焦磷酸酯类似物，从受试者中至少一种致癌或毒性金属保护毒蕈碱受体的方法和组合物。 用于通过施用焦磷酸酯类似物来预防受损于受试者中毒蕈碱受体功能的金属诱导或引起的至少一种疾病的方法和组合物。 通过施用焦磷酸酯类似物减少金属离子的毒性作用和减少金属中毒的方法和组合物。
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7.发明授权Methods and compositions for protecting and treating at least one muscarinic receptor from dysfunction not resulting from oxidative stress, toxic actions of metals or infectious agents by administering a pyrophosphate analog 有权用于保护和治疗至少一种毒蕈碱受体的方法和组合物不是由氧化应激引起的功能障碍，金属或感染因子的毒性作用，通过施用焦磷酸盐类似物公开(公告)号：US07972595B2
公开(公告)日：2011-07-05
申请号：US11191901
申请日：2005-07-28
CPC分类号： A61K31/6615 , A61K31/352 , A61K31/409 , A61K31/66 , A61K31/661 , A61K31/662 , A61K31/663 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7084 , A61K31/7105 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for protecting and treating a muscarinic receptor in a subject in need thereof from dysfunction not resulting from oxidative stress, toxic actions of metals or metal ions, or infectious agents by administering a pyrophosphate analog.
摘要翻译： 用于保护和治疗有需要的受试者的毒蕈碱受体的方法和组合物，其不是由氧化应激引起的功能障碍，金属或金属离子的毒性作用或通过施用焦磷酸酯类似物的感染剂。
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8.发明授权Methods and compositions for increasing the efficacy of an agent that directly or indirectly affects a muscarinic receptor through administration of a pyrophosphate analog 有权通过给予焦磷酸酯类似物直接或间接地影响毒蕈碱受体的药物的功效增加的方法和组合物公开(公告)号：US09072756B2
公开(公告)日：2015-07-07
申请号：US11220222
申请日：2005-09-06
IPC分类号： A61K31/70 , A61K31/6615 , A61K31/352 , A61K31/409 , A61K31/66 , A61K31/661 , A61K31/662 , A61K31/663 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7084 , A61K31/7105 , A61K45/06
CPC分类号： A61K31/6615 , A61K31/352 , A61K31/409 , A61K31/66 , A61K31/661 , A61K31/662 , A61K31/663 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7084 , A61K31/7105 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for increasing the efficacy of an agent that directly or indirectly affects a muscarinic receptor by administering a pyrophosphate analog. Methods and compositions for protecting a pharmacological agent in a formulation, comprising combining the pharmacological agent with at least one pyrophosphate analog. Methods and compositions for increasing the efficacy of a neurologic agent by administering at least one pyrophosphate analog. Methods and compositions for increasing the efficacy of an agent that neither directly nor indirectly affects a muscarinic receptor by administering at least one pyrophosphate analog.
摘要翻译： 通过施用焦磷酸酯类似物来增加直接或间接影响毒蕈碱受体的药剂的功效的方法和组合物。 用于保护制剂中药理学试剂的方法和组合物，包括将药理学试剂与至少一种焦磷酸酯类似物组合。 通过施用至少一种焦磷酸酯类似物来增加神经病药物的功效的方法和组合物。 通过施用至少一种焦磷酸酯类似物来增加药物的功效的方法和组合物，其既不直接也不间接影响毒蕈碱受体。
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9.发明授权公开(公告)号：US09445991B2
公开(公告)日：2016-09-20
申请号：US15082210
申请日：2016-03-28
CPC分类号： A61K9/0043 , A61K35/28 , A61K35/30 , A61K38/47 , A61K2300/00
摘要： Methods and compositions for preventing and treating the damaged and/or degenerating CNS experiencing loss or death of CNS cells. Various embodiments of the invention transport a therapeutically effective amount of, inter alia at least one therapeutic cell to the CNS by intranasal application to the upper-third of the nasal cavity, thereby bypassing the blood-brain barrier. A pharmaceutical composition according to the invention may comprise at least one therapeutic cell, at least one delivery-enhancement agent, at least one antibiotic, at least one regulatory factor and/or at least one immunosuppressive agent, wherein the composition is delivered to the upper-third of the nasal cavity. The therapeutic cells, once delivered to the CNS, migrate preferentially to the area of damage or degeneration or injury.
摘要翻译： 用于预防和治疗CNS细胞损伤或死亡的损伤和/或退化的CNS的方法和组合物。 本发明的各种实施方案通过鼻内施用到鼻腔上三分之一，从而绕过血脑屏障，将治疗有效量的尤其是至少一种治疗细胞转运至CNS。 根据本发明的药物组合物可以包含至少一种治疗细胞，至少一种递送增强剂，至少一种抗生素，至少一种调节因子和/或至少一种免疫抑制剂，其中所述组合物被递送至上 三分之一的鼻腔。 一旦递送到CNS的治疗细胞优先迁移到损伤或退化或损伤的区域。
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10.发明授权Intranasal delivery of therapeutic enzymes to the central nervous system for the treatment of lysosomal storage diseases 有权将治疗性酶的鼻内递送至中枢神经系统用于治疗溶酶体贮积病公开(公告)号：US08609088B2
公开(公告)日：2013-12-17
申请号：US13465575
申请日：2012-05-07
IPC分类号： A61K38/46
CPC分类号： C12N15/86 , A61K9/0043 , A61K38/46 , A61K38/465 , A61K38/47 , C12N9/18 , C12N9/2402 , C12Y301/06013 , C12Y302/01022 , C12Y302/01023 , C12Y302/01031 , C12Y302/01045 , C12Y302/0105 , C12Y302/01052 , C12Y302/01076
摘要： The invention provides a method to prevent, inhibit or treat one or more neurological symptoms associated with a lysosomal storage disease in a mammal in need thereof, which includes intranasally administering to the mammal a composition comprising an effective amount of a lysosomal storage enzyme or a recombinant adeno-associated virus vector comprising an open reading frame encoding a lysosomal storage enzyme. Also provided are compositions and devices useful in the methods.
摘要翻译： 本发明提供了在有需要的哺乳动物中预防，抑制或治疗与溶酶体贮积病相关的一种或多种神经症状的方法，其包括向哺乳动物施用包含有效量的溶酶体贮积酶或重组体 腺相关病毒载体，其包含编码溶酶体贮积酶的开放阅读框。 还提供了在该方法中有用的组合物和装置。
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