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公开(公告)号：US20240133739A1
公开(公告)日：2024-04-25
申请号：US18319615
申请日：2023-05-17
Applicant: Wayne State University
Inventor： Gregory William Auner , Michelle Ann Brusatori , Changhe Huang
CPC classification number: G01J3/44 , G01J3/0208 , G01J3/1838 , G01J3/2803 , G01N21/03 , G01J2003/1861
Abstract: Apparatuses, systems, and methods for Raman spectroscopy are described. In certain implementations, a spectrometer is provided. The spectrometer may include a plurality of optical elements, comprising an entrance aperture, a collimating element, a volume phase holographic grating, a focusing element, and a detector array. The plurality of optical elements are configured to transfer the light beam from the entrance aperture to the detector array with a high transfer efficiency over a preselected spectral band.
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公开(公告)号：US11698304B2
公开(公告)日：2023-07-11
申请号：US16451901
申请日：2019-06-25
Applicant: Wayne State University
Inventor： Gregory William Auner , Michelle Ann Brusatori , Changhe Huang
CPC classification number: G01J3/44 , G01J3/0208 , G01J3/1838 , G01J3/2803 , G01N21/03 , G01J2003/1861
Abstract: Apparatuses, systems, and methods for Raman spectroscopy are described. In certain implementations, a spectrometer is provided. The spectrometer may include a plurality of optical elements, comprising an entrance aperture, a collimating element, a volume phase holographic grating, a focusing element, and a detector array. The plurality of optical elements are configured to transfer the light beam from the entrance aperture to the detector array with a high transfer efficiency over a preselected spectral band.
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3.发明授权公开(公告)号：US11375897B2
公开(公告)日：2022-07-05
申请号：US16605926
申请日：2018-04-20
Applicant: HENRY FORD HEALTH SYSTEM , WAYNE STATE UNIVERSITY
Inventor： Gregory William Auner , Michelle Brusatori , Steven N. Kalkanis , Lisa Scarpace
IPC: A61B5/00
Abstract: A system for characterization of a brain tissue sample includes a laser having an excitation fiber and a probe coupled to the excitation fiber for irradiating the brain tissue sample with light at an excitation wavelength. The probe further includes a plurality of return fibers for receiving light scattered from the brain tissue sample, wherein each return fiber includes a microfilter that permits light to pass for a different, spaced apart marker region. A Raman spectrometer is in communication with the plurality of return fibers, and a processor is in communication with the Raman spectrometer for analyzing Raman spectra within the marker regions to identify a tissue type of the brain tissue sample as one of normal white matter brain tissue, normal grey matter brain tissue, brain tumor tissue, infiltrating tumor tissue, and necrotic tissue.
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公开(公告)号：US11236379B2
公开(公告)日：2022-02-01
申请号：US16284050
申请日：2019-02-25
Applicant: Seraph Biosciences, Inc. , Wayne State University
Inventor： Gregory William Auner , Charles Shanley , Michelle Brusatori , Tara Twomey , David Sant
Abstract: A Raman spectroscopy based system and method for examination and interrogation provides a method for rapid and cost effective screening of various protein-based compounds such as bacteria, virus, drugs, and tissue abnormalities. A hand-held spectroscope includes a laser and optical train for generating a Raman-shifting sample signal, signal processing and identification algorithms for signal conditioning and target detection with combinations of ultra-high resolution micro-filters and an imaging detector array to provide specific analysis of target spectral peaks within discrete spectral bands associated with a target pathogen.
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Patent Agency Ranking
公开(公告)号：US20200264050A1
公开(公告)日：2020-08-20
申请号：US16451901
申请日：2019-06-25
Applicant: Wayne State University
Inventor： Gregory William Auner , Michelle Ann Brusatori , Changhe Huang
Abstract: Apparatuses, systems, and methods for Raman spectroscopy are described. In certain implementations, a spectrometer is provided. The spectrometer may include a plurality of optical elements, comprising an entrance aperture, a collimating element, a volume phase holographic grating, a focusing element, and a detector array. The plurality of optical elements are configured to transfer the light beam from the entrance aperture to the detector array with a high transfer efficiency over a preselected spectral band.
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公开(公告)号：US10253346B2
公开(公告)日：2019-04-09
申请号：US14910459
申请日：2014-08-07
Applicant: Seraph Biosciences, Inc. , Wayne State University
Inventor： Gregory William Auner , Charles Shanley , Michelle Brusatori , Tara Twomey , David Sant
Abstract: A Raman spectroscopy based system and method for examination and interrogation provides a method for rapid and cost effective screening of various protein-based compounds such as bacteria, virus, drugs, and tissue abnormalities. A hand-held spectroscope includes a laser and optical train for generating a Raman-shifting sample signal, signal processing and identification algorithms for signal conditioning and target detection with combinations of ultra-high resolution micro-filters and an imaging detector array to provide specific analysis of target spectral peaks within discrete spectral bands associated with a target pathogen.
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公开(公告)号：US20240230407A9
公开(公告)日：2024-07-11
申请号：US18319615
申请日：2023-05-18
Applicant: Wayne State University
Inventor： Gregory William Auner , Michelle Ann Brusatori , Changhe Huang
CPC classification number: G01J3/44 , G01J3/0208 , G01J3/1838 , G01J3/2803 , G01N21/03 , G01J2003/1861
Abstract: Apparatuses, systems, and methods for Raman spectroscopy are described. In certain implementations, a spectrometer is provided. The spectrometer may include a plurality of optical elements, comprising an entrance aperture, a collimating element, a volume phase holographic grating, a focusing element, and a detector array. The plurality of optical elements are configured to transfer the light beam from the entrance aperture to the detector array with a high transfer efficiency over a preselected spectral band.
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公开(公告)号：US20190203255A1
公开(公告)日：2019-07-04
申请号：US16284050
申请日：2019-02-25
Applicant: Seraph Biosciences, Inc. , Wayne State University
Inventor： Gregory William Auner , Charles Shanley , Michelle Brusatori , Tara Twomey , David Sant
CPC classification number: C12Q1/04 , A61B5/0075 , A61B5/445 , A61B5/6815 , A61B5/6819 , A61B5/682 , A61B5/6846 , C12Q1/14 , G01J3/0208 , G01J3/0264 , G01J3/0272 , G01J3/0291 , G01J3/44 , G01J3/4406 , G01J3/4412 , G01N21/65 , G01N2201/0221 , G01N2333/11 , G01N2333/31 , G01N2333/34
Abstract: A Raman spectroscopy based system and method for examination and interrogation provides a method for rapid and cost effective screening of various protein-based compounds such as bacteria, virus, drugs, and tissue abnormalities. A hand-held spectroscope includes a laser and optical train for generating a Raman-shifting sample signal, signal processing and identification algorithms for signal conditioning and target detection with combinations of ultra-high resolution micro-filters and an imaging detector array to provide specific analysis of target spectral peaks within discrete spectral bands associated with a target pathogen.
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9.发明申请公开(公告)号：US20160177366A1
公开(公告)日：2016-06-23
申请号：US14910459
申请日：2014-08-07
Applicant: SERAPH BIOSCIENCES, LLC , WAYNE STATE UNIVERSITY
Inventor： Gregory William Auner , Charles Shanley , Michelle Brusatori , Tara Twomey , David Sant
CPC classification number: C12Q1/04 , A61B5/0075 , A61B5/445 , A61B5/6815 , A61B5/6819 , A61B5/682 , A61B5/6846 , C12Q1/14 , G01J3/0208 , G01J3/0264 , G01J3/0272 , G01J3/0291 , G01J3/44 , G01J3/4406 , G01J3/4412 , G01N21/65 , G01N2201/0221 , G01N2333/11 , G01N2333/31 , G01N2333/34
Abstract: A Raman spectroscopy based system and method for examination and interrogation provides a method for rapid and cost effective screening of various protein-based compounds such as bacteria, virus, drugs, and tissue abnormalities. A hand-held spectroscope includes a laser and optical train for generating a Raman-shifting sample signal, signal processing and identification algorithms for signal conditioning and target detection with combinations of ultra-high resolution micro-filters and an imaging detector array to provide specific analysis of target spectral peaks within discrete spectral bands associated with a target pathogen.
Abstract translation: 基于拉曼光谱的系统和检查和询问方法提供了用于快速和成本有效地筛选各种基于蛋白质的化合物如细菌，病毒，药物和组织异常的方法。 手持式分光镜包括用于产生拉曼移位采样信号的激光和光学系列，用于信号调节和目标检测的信号处理和识别算法，其中包括超高分辨率微滤器和成像检测器阵列的组合，以提供特定分析 在与目标病原体相关的离散光谱带内的目标光谱峰。
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