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1.发明申请APPARATUS AND METHOD FOR WOUND TREATMENT EMPLOYING PERIODIC SUB-ATMOSPHERIC PRESSURE 有权用于治疗周期性亚大气压力的装置和方法公开(公告)号：US20140155790A1
公开(公告)日：2014-06-05
申请号：US14082951
申请日：2013-11-18
IPC分类号： A61H7/00
CPC分类号： A61H7/001 , A61M1/0037 , A61M1/0088
摘要： A tissue treatment apparatus and method are provided for treating tissue by the application of the time-varying sub-atmospheric pressure. The apparatus includes a cover adapted to cover a wound and adapted to maintain sub-atmospheric pressure the site of the wound. The apparatus further includes a source of suction configured to generate a time-varying sub-atmospheric pressure having a periodic waveform comprising a gradual change in pressure. The suction source cooperates with the cover to supply the time-varying sub-atmospheric pressure under the cover to the wound. The time-varying sub-atmospheric pressure may vary between a first pressure value below the inherent tissue tension of the wound tissue and a second pressure value above the inherent tissue tension of the wound tissue.
摘要翻译： 提供了一种通过应用时变的次大气压来处理组织的组织处理装置和方法。 该装置包括适于覆盖伤口并适于在伤口的部位保持低于大气压的盖。 该装置还包括被配置为产生具有包括逐渐变化的周期性波形的时变的次大气压的抽吸源。 抽吸源与盖配合，将盖下的时变大气压提供给伤口。 时变的次大气压力可以在低于伤口组织的固有组织张力的第一压力值和高于伤口组织的固有组织张力的第二压力值之间变化。
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公开(公告)号：US20130267952A1
公开(公告)日：2013-10-10
申请号：US13896750
申请日：2013-05-17
IPC分类号： A61B17/60
CPC分类号： A61B17/66 , A61B17/60 , A61B17/864 , A61B17/866 , A61B17/8685 , A61B2017/00544
摘要： An external fixation assembly includes a plurality of hollow pins that are inserted into a patient's bone. Each pin has an interior bore and a plurality of apertures extending through the pin wall from the bore. The pin may be coupled to a source of vacuum pressure operable to create reduced pressure in the tissue surrounding the pin. A cover is placed around the pin and sealed to provide a fluid-tight enclosure that maintains reduced pressure around the pin. A method for applying external fixation using the fixator pins described above includes the steps of inserting each pin through a skin opening, positioning the pin apertures near selected tissue, covering the skin opening with a sealed enclosure, connecting the pins to a source of vacuum pressure, and activating the source of vacuum pressure to create reduced pressure in the patient's tissue at or near the bone.
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3.发明申请APPARATUS AND METHOD FOR WOUND TREATMENT EMPLOYING PERIODIC SUB-ATMOSPHERIC PRESSURE 审中-公开用于治疗周期性亚大气压力的装置和方法公开(公告)号：US20130030396A1
公开(公告)日：2013-01-31
申请号：US13633627
申请日：2012-10-02
IPC分类号： A61M1/00
CPC分类号： A61H7/001 , A61M1/0037 , A61M1/0088
摘要： A tissue treatment apparatus and method are provided for treating tissue by the application of the time-varying sub-atmospheric pressure. The apparatus includes a cover adapted to cover a wound and adapted to maintain sub-atmospheric pressure the site of the wound. The apparatus further includes a source of suction configured to generate a time-varying sub-atmospheric pressure having a periodic waveform comprising a gradual change in pressure. The suction source cooperates with the cover to supply the time-varying sub-atmospheric pressure under the cover to the wound. The time-varying sub-atmospheric pressure may vary between a first pressure value below the inherent tissue tension of the wound tissue and a second pressure value above the inherent tissue tension of the wound tissue.
摘要翻译： 提供了一种通过应用时变的次大气压来处理组织的组织处理装置和方法。 该装置包括适于覆盖伤口并适于在伤口的部位保持低于大气压的盖。 该装置还包括被配置为产生具有包括逐渐变化的周期性波形的时变的次大气压的抽吸源。 抽吸源与盖配合，将盖下的时变大气压提供给伤口。 时变的次大气压力可以在低于伤口组织的固有组织张力的第一压力值和高于伤口组织的固有组织张力的第二压力值之间变化。
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公开(公告)号：US09675358B2
公开(公告)日：2017-06-13
申请号：US14391346
申请日：2013-03-15
IPC分类号： A61B17/11 , A61L27/18 , A61L27/44 , A61L27/50 , A61F2/00 , A61L27/26 , A61L27/58 , C08G63/12 , C08G63/47 , H01B1/12 , A61B17/00
CPC分类号： A61B17/1128 , A61B2017/00004 , A61B2017/00831 , A61B2017/00991 , A61B2017/1132 , A61F2/0077 , A61L27/18 , A61L27/26 , A61L27/446 , A61L27/50 , A61L27/58 , A61L2400/12 , A61L2430/32 , C08G63/12 , C08G63/47 , H01B1/125 , C08L67/00
摘要： A biphasic material and devices comprising the same are provided for the development of conductive conduits that may be used for the treatment of peripheral nerve injury. These devices or conduits are designed such that repeated electric field gradients can be initiated to promote neurite and axonal outgrowth. Conducting conduits using doped synthetic and/or natural polymers create specifically patterned high and low conducting segmented materials, which are mechanically used to produce the electrical properties needed for nerve conduits. These electrical properties stimulate neurite outgrowth and axonal repair following a peripheral nerve transection.
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公开(公告)号：US20140350499A1
公开(公告)日：2014-11-27
申请号：US14458790
申请日：2014-08-13
发明人： Louis C. Argenta , David L. Carroll , Nicole H. Levi-Polyachenko , Jie Liu , Michael J. Morykwas , Stephen Tatter , William D. Wagner
CPC分类号： A61M1/0088 , A61F13/00021 , A61M1/0023 , A61M2210/1003
摘要： The present invention provides devices and methods that treat damaged spinal cord tissue, such as spinal tissue damaged by disease, infection, or trauma, which may lead to the presence of swelling, compression, and compromised blood flow secondary to interstitial edema.
摘要翻译： 本发明提供了治疗损伤的脊髓组织（例如由疾病，感染或创伤损伤的脊髓组织）的装置和方法，其可导致继发于间质性水肿的肿胀，压缩和受损的血流。
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公开(公告)号：US20170368242A1
公开(公告)日：2017-12-28
申请号：US15700667
申请日：2017-09-11
发明人： Louis C. Argenta , David L. Carroll , Nicole H. Levi , Jie Liu , Michael J. Morykwas , Stephen Tatter , William D. Wagner
CPC分类号： A61M1/0088 , A61F13/00021 , A61M1/0023 , A61M2210/1003
摘要： The present invention provides devices and methods that treat damaged spinal cord tissue, such as spinal tissue damaged by disease, infection, or trauma, which may lead to the presence of swelling, compression, and compromised blood flow secondary to interstitial edema.
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公开(公告)号：US09566089B2
公开(公告)日：2017-02-14
申请号：US14714678
申请日：2015-05-18
CPC分类号： A61B17/66 , A61B17/60 , A61B17/864 , A61B17/866 , A61B17/8685 , A61B2017/00544
摘要： An external fixation assembly includes a plurality of hollow pins that are inserted into a patient's bone. Each pin has an interior bore and a plurality of apertures extending through the pin wall from the bore. The pin may be coupled to a source of vacuum pressure operable to create reduced pressure in the tissue surrounding the pin. A cover is placed around the pin and sealed to provide a fluid-tight enclosure that maintains reduced pressure around the pin. A method for applying external fixation using the fixator pins described above includes the steps of inserting each pin through a skin opening, positioning the pin apertures near selected tissue, covering the skin opening with a sealed enclosure, connecting the pins to a source of vacuum pressure, and activating the source of vacuum pressure to create reduced pressure in the patient's tissue at or near the bone.
摘要翻译： 外部固定组件包括插入患者骨骼中的多个中空销。 每个销具有内孔和从孔延伸穿过销壁的多个孔。 销可以联接到真空压力源，可操作以在围绕销的组织中产生减小的压力。 一个盖被放置在销的周围并被密封以提供一个流体密封的外壳，其保持围绕销的减压。 使用上述固定销来施加外部固定的方法包括以下步骤：将每个销插入皮肤开口，将销孔定位在所选组织附近，用密封的外壳覆盖皮肤开口，将销连接到真空压力源 并且激活真空压力源以在患者的组织中在骨骼处或骨附近产生减压。
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8.发明申请NOVEL NANOFIBER-BASED GRAFT FOR HEART VALVE REPLACEMENT AND METHODS OF USING THE SAME 审中-公开用于心脏瓣膜更换的新型基于NANOFIBER的骨架及其使用方法公开(公告)号：US20150272729A1
公开(公告)日：2015-10-01
申请号：US14438142
申请日：2013-10-25
发明人： William D. Wagner , Levi-Polyachenko Nicole , Rui Wang , Louis C. Argenta , Michael J. Morykwas
CPC分类号： A61F2/2412 , A61F2/2415 , A61F2/82 , A61K9/70 , A61L27/26 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2400/12 , A61L2430/20 , C08J9/0061 , C08J2389/00 , C08J2389/06 , C08J2467/02 , C08J2489/00 , C08J2489/06 , C08L89/00 , C08L89/06 , C08L2201/06 , C08L2203/02 , C08L2203/12 , C08L2205/02 , C08L2205/03 , Y10T428/298 , C08L31/06
摘要： Nanofiber-based biomaterials containing fibroin for wound repair and tissue replacement and, more particularly, heart valve replacement.
摘要翻译： 含有丝素蛋白用于伤口修复和组织置换的纳米纤维生物材料，更具体地说，是心脏瓣膜置换。
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公开(公告)号：US20150032137A1
公开(公告)日：2015-01-29
申请号：US14391346
申请日：2013-03-15
发明人： William D. Wagner , Nicole Levi-Polyachenko , Tabitha Rosenbalm , Louis C. Argenta , Michael J. Morykwas
CPC分类号： A61B17/1128 , A61B2017/00004 , A61B2017/00831 , A61B2017/00991 , A61B2017/1132 , A61F2/0077 , A61L27/18 , A61L27/26 , A61L27/446 , A61L27/50 , A61L27/58 , A61L2400/12 , A61L2430/32 , C08G63/12 , C08G63/47 , H01B1/125 , C08L67/00
摘要： A biphasic material and devices comprising the same are provided for the development of conductive conduits that may be used for the treatment of peripheral nerve injury. These devices or conduits are designed such that repeated electric field gradients can be initiated to promote neurite and axonal outgrowth. Conducting conduits using doped synthetic and/or natural polymers create specifically patterned high and low conducting segmented materials, which are mechanically used to produce the electrical properties needed for nerve conduits. These electrical properties stimulate neurite outgrowth and axonal repair following a peripheral nerve transection.
摘要翻译： 提供双相材料和包含该双相材料的装置用于开发可用于治疗周围神经损伤的导电导管。 这些装置或管道被设计成使得可以开始重复的电场梯度以促进神经突和轴突向外生长。 使用掺杂的合成和/或天然聚合物的导管产生专门图案化的高和低导电分段材料，其被机械地用于产生神经导管所需的电性能。 这些电气特性刺激周围神经横断后的神经突向外生长和轴突修复。
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公开(公告)号：US20130072827A1
公开(公告)日：2013-03-21
申请号：US13622009
申请日：2012-09-18
发明人： Louis C. Argenta , David L. Carroll , Nicole H. Levi , Michael J. Morykwas , Stephen Tatter , William D. Wagner , Jie Liu
IPC分类号： A61H7/00
CPC分类号： A61M1/0088 , A61H7/00 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/56 , A61M2207/00 , A61M2210/0693 , B29C47/0076 , B29C64/112 , B29C67/202 , B29K2089/00 , B29K2995/006 , B29L2031/753 , C08L67/04 , C08L5/08
摘要： The present invention relates generally to a device and method for treating tissues of the central nervous system and more particularly, but not exclusively, to a device and method for treating the brain tissue.
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