公开(公告)号：US12023341B2

公开(公告)日：2024-07-02

申请号：US17235382

申请日：2021-04-20

Applicant: Wake Forest University

Inventor： Ulrich Bierbach ,  Shenjie Zhang ,  Xiyuan Yao ,  Ikeer Y. Mancera-Ortiz ,  Noah H. Watkins

IPC: C07F15/00 ,  A61K31/165 ,  A61K31/19 ,  A61K31/4406 ,  A61K31/444 ,  A61K31/455 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/555 ,  A61K31/706 ,  A61K38/15 ,  A61P35/00

CPC classification number: A61K31/555 ,  A61K31/165 ,  A61K31/19 ,  A61K31/4406 ,  A61K31/444 ,  A61K31/455 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/706 ,  A61K38/15 ,  A61P35/00 ,  C07F15/0093

Abstract: Platinum-acridines and analogs thereof as cytotoxic agents for cancer treatment. Also provided methods of using hMATE1 (SLC47A1) as a biomarker to identify tumors that are likely to respond to the agents, and epigenetically sensitizing tumor tissue to anticancer drugs targeting this membrane transporter.

公开(公告)号：US20250059224A1

公开(公告)日：2025-02-20

申请号：US18760898

申请日：2024-07-01

Applicant: Wake Forest University

Inventor： Ulrich Bierbach ,  Shenjie Zhang ,  Xiyuan Yao ,  Noah H. Watkins

IPC: C07F15/00 ,  A61K31/555 ,  A61K47/54 ,  A61K47/60 ,  A61P35/00

Abstract: Platinum-acridines and analogs thereof as cytotoxic agents for cancer treatment. Also provided methods of using hMATE1 (SLC47A1) as a biomarker to identify tumors that are likely to respond to the agents, and epigenetically sensitizing tumor tissue to anticancer drugs targeting this membrane transporter.

公开(公告)号：US11591357B2

公开(公告)日：2023-02-28

申请号：US16642074

申请日：2018-08-28

Applicant: Wake Forest University

Inventor： Ulrich Bierbach ,  Xiyuan Yao ,  Hanwen Wang

IPC: C07F15/00 ,  A61K47/51

Abstract: The present invention relates to payloads containing functionalized platinum-(benz)acridine hybrid agents as cytotoxic warheads and a method of synthesizing the payloads. The payload can be regioselectively conjugated to a biologically active moiety in order to facilitate the delivery and/or enhance the activity of the platinum compound.

公开(公告)号：US20210330679A1

公开(公告)日：2021-10-28

申请号：US17235382

申请日：2021-04-20

Applicant: Wake Forest University

Inventor： Ulrich Bierbach ,  Shenjie Zhang ,  Xiyuan Yao ,  Ikeer Y. Mancera-Ortiz ,  Noah H. Watkins

IPC: A61K31/555 ,  C07F15/00 ,  A61K31/5377 ,  A61K31/519 ,  A61K31/496 ,  A61K31/165 ,  A61K31/19 ,  A61K38/15 ,  A61K31/4406 ,  A61K31/455 ,  A61K31/706 ,  A61K31/444 ,  A61P35/00

Abstract: Platinum-acridines and analogs thereof as cytotoxic agents for cancer treatment. Also provided methods of using hMATE1 (SLC47A1) as a biomarker to identify tumors that are likely to respond to the agents, and epigenetically sensitizing tumor tissue to anticancer drugs targeting this membrane transporter.

公开(公告)号：US20200181185A1

公开(公告)日：2020-06-11

申请号：US16642074

申请日：2018-08-28

Applicant: Wake Forest University

Inventor： Ulrich Bierbach ,  Xiyuan Yao ,  Hanwen Wang

IPC: C07F15/00 ,  A61K47/51

Abstract: The present invention relates to payloads containing functionalized platinum-(benz)acridine hybrid agents as cytotoxic warheads and a method of synthesizing the payloads. The payload can be regioselectively conjugated to a biologically active moiety in order to facilitate the delivery and/or enhance the activity of the platinum compound.