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公开(公告)号：US11591357B2
公开(公告)日：2023-02-28
申请号：US16642074
申请日：2018-08-28
Applicant: Wake Forest University
Inventor： Ulrich Bierbach , Xiyuan Yao , Hanwen Wang
Abstract: The present invention relates to payloads containing functionalized platinum-(benz)acridine hybrid agents as cytotoxic warheads and a method of synthesizing the payloads. The payload can be regioselectively conjugated to a biologically active moiety in order to facilitate the delivery and/or enhance the activity of the platinum compound.
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2.发明申请公开(公告)号：US20200181185A1
公开(公告)日：2020-06-11
申请号：US16642074
申请日：2018-08-28
Applicant: Wake Forest University
Inventor： Ulrich Bierbach , Xiyuan Yao , Hanwen Wang
Abstract: The present invention relates to payloads containing functionalized platinum-(benz)acridine hybrid agents as cytotoxic warheads and a method of synthesizing the payloads. The payload can be regioselectively conjugated to a biologically active moiety in order to facilitate the delivery and/or enhance the activity of the platinum compound.
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