Invention Application
- Patent Title: PLATINUM-ACRIDINE COMPOUNDS AND METHODS OF TREATING CANCERS
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Application No.: US18760898Application Date: 2024-07-01
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Publication No.: US20250059224A1Publication Date: 2025-02-20
- Inventor: Ulrich Bierbach , Shenjie Zhang , Xiyuan Yao , Noah H. Watkins
- Applicant: Wake Forest University
- Applicant Address: US NC Winston-Salem
- Assignee: Wake Forest University
- Current Assignee: Wake Forest University
- Current Assignee Address: US NC Winston-Salem
- Main IPC: C07F15/00
- IPC: C07F15/00 ; A61K31/555 ; A61K47/54 ; A61K47/60 ; A61P35/00
Abstract:
Platinum-acridines and analogs thereof as cytotoxic agents for cancer treatment. Also provided methods of using hMATE1 (SLC47A1) as a biomarker to identify tumors that are likely to respond to the agents, and epigenetically sensitizing tumor tissue to anticancer drugs targeting this membrane transporter.
Information query
