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    Technique for photodisruptive multi-pulse treatment of a material
    1.
    发明授权
    Technique for photodisruptive multi-pulse treatment of a material 有权

    公开(公告)号：US10159602B2

    公开(公告)日：2018-12-25

    申请号：US14785826

    申请日：2014-05-07

    申请人： Wavelight GMBH

    发明人： Klaus Vogler ,  Christof Donitzky

    IPC分类号： A61B18/20 ,  A61F9/008 ,  H01S3/00

    摘要： Embodiments of the invention provide a method and apparatus for laser-processing a material. In the embodiments, a diffraction-limited beam of pulsed laser radiation is diffracted by a diffraction device to generate a diffracted beam. The diffracted beam is subsequently focused onto the material and is controlled in time and space to irradiate the material at a target position with radiation from a set of radiation pulses of the diffracted beam so that each radiation pulse from the set of radiation pulses is incident at the target position with a cross-sectional portion of the diffracted beam, the cross-sectional portion including a local intensity maximum of the diffracted beam. The beam cross-sectional portions of at least a subset of the pulses of the set include each a different local intensity maxi-mum. In this way, a multi-pulse application for generating a photo-disruption at a target location of the material can be implemented.

    CROSSLINKING CONTROL
    3.
    发明申请
    CROSSLINKING CONTROL 审中-公开
    交互控制

    公开(公告)号：US20160236006A1

    公开(公告)日：2016-08-18

    申请号：US15024827

    申请日：2013-10-30

    申请人： WAVELIGHT GMBH

    发明人： Christof Donitzky ,  Armin Wellhoefer

    IPC分类号： A61N5/06 ,  A61F9/008 ,  A61F9/007

    摘要： A crosslinking control system, the use of the crosslinking control system, a laser system comprising the crosslinking control system, a crosslinking control method and a method for laser treatment are provided. The crosslinking control system comprises a photosensitizer providing unit, a light source configured to provide light having a wavelength suitable to activate the photosensitizer introduced into or applied onto the tissue for crosslinking, and a control computer.

    摘要翻译： 交联控制系统，交联控制系统的使用，包括交联控制系统的激光系统，交联控制方法和激光处理方法。 交联控制系统包括光敏剂提供单元，光源，其被配置为提供具有适于激活引入或施加到组织上用于交联的光敏剂的波长的光，以及控制计算机。

    TECHNIQUE FOR PHOTODISRUPTIVE MULTI-PULSE TREATMENT OF A MATERIAL
    4.
    发明申请
    TECHNIQUE FOR PHOTODISRUPTIVE MULTI-PULSE TREATMENT OF A MATERIAL 审中-公开
    用于光电多晶脉冲处理材料的技术

    公开(公告)号：US20160166431A1

    公开(公告)日：2016-06-16

    申请号：US14785826

    申请日：2014-05-07

    申请人： Wavelight GMBH

    发明人： Klaus Vogler ,  Christof Donitzky

    IPC分类号： A61F9/008 ,  H01S3/00

    CPC分类号： A61F9/0084 ,  A61B18/20 ,  A61F9/00825 ,  A61F2009/00872 ,  A61F2009/00897 ,  H01S3/005

    摘要： Embodiments of the invention provide a method and apparatus for laser-processing a material. In the embodiments, a diffraction-limited beam of pulsed laser radiation is diffracted by a diffraction device to generate a diffracted beam. The diffracted beam is subsequently focused onto the material and is controlled in time and space to irradiate the material at a target position with radiation from a set of radiation pulses of the diffracted beam so that each radiation pulse from the set of radiation pulses is incident at the target position with a cross-sectional portion of the diffracted beam, the cross-sectional portion including a local intensity maximum of the diffracted beam. The beam cross-sectional portions of at least a subset of the pulses of the set include each a different local intensity maximum. In this way, a multi-pulse application for generating a photo-disruption at a target location of the material can be implemented.

    摘要翻译： 本发明的实施例提供了用于激光处理材料的方法和装置。 在实施例中，脉冲激光辐射的衍射受限束被衍射装置衍射以产生衍射光束。 衍射光束随后聚焦在材料上，并在时间和空间上进行控制，以便利用来自衍射光束的一组辐射脉冲的辐射在目标位置照射材料，使得来自该组辐射脉冲的每个辐射脉冲入射到 所述目标位置具有所述衍射光束的横截面部分，所述横截面部分包括所述衍射光束的局部强度最大值。 集合的脉冲的至少一个子集的光束横截面部分包括每个不同的局部强度最大值。 以这种方式，可以实现用于在材料的目标位置产生光中断的多脉冲应用。

    TECHNIQUE FOR SETTING ENERGY-RELATED LASER-PULSE PARAMETERS
    5.
    发明申请
    TECHNIQUE FOR SETTING ENERGY-RELATED LASER-PULSE PARAMETERS 审中-公开
    设置能量相关激光脉冲参数的技术

    公开(公告)号：US20160158061A1

    公开(公告)日：2016-06-09

    申请号：US14787240

    申请日：2014-05-22

    申请人： WAVELIGHT GMBH

    发明人： Matthias Foesel ,  Christof Donitzky ,  Klaus Vogler ,  Olaf Kittelmann

    IPC分类号： A61F9/008

    CPC分类号： A61F9/0084

    摘要： A method for energy setting of pulsed, focused laser radiation is provided. In the method, a relationship between a threshold pulse energy required for causing irreversible damage in a material and a pulse duration is established. The relationship allows for obtaining a threshold pulse energy for each of a plurality of pulse durations, including one or more pulse durations in a range between 200 fs and smaller. The relationship defines a decreasing threshold pulse energy for a decreasing pulse duration in the range between 200 fs and smaller. For a given pulse duration in the range between 200 fs and smaller, an associated threshold pulse energy is determined based on the established relationship. The pulse energy of the laser radiation is set based on the determined associated threshold pulse energy.

    摘要翻译： 提供了脉冲聚焦激光辐射的能量设定方法。 在该方法中，建立了在材料中引起不可逆损伤所需的阈值脉冲能量与脉冲持续时间之间的关系。 该关系允许获得多个脉冲持续时间中的每一个的阈值脉冲能量，包括在200fs和更小的范围内的一个或多个脉冲持续时间。 该关系定义了在200fs和更小之间的范围内减小的脉冲持续时间的下降阈值脉冲能量。 对于在200fs和更小的范围内的给定脉冲持续时间，相关联的阈值脉冲能量基于建立的关系来确定。 基于确定的相关阈值脉冲能量来设置激光辐射的脉冲能量。

    DEVICE AND PROCESS FOR MACHINING THE CORNEA OF A HUMAN EYE WITH FOCUSED PULSED LASER RADIATION
    6.
    发明申请
    DEVICE AND PROCESS FOR MACHINING THE CORNEA OF A HUMAN EYE WITH FOCUSED PULSED LASER RADIATION 有权
    用聚焦脉冲激光辐射加工人眼的脊椎的装置和方法

    公开(公告)号：US20150305941A1

    公开(公告)日：2015-10-29

    申请号：US14793845

    申请日：2015-07-08

    申请人： WaveLight GmbH

    发明人： Christof Donitzky ,  Mathias Woelfel ,  Johannes Krause

    IPC分类号： A61F9/008

    CPC分类号： A61F9/00825 ,  A61F9/00831 ,  A61F9/009 ,  A61F2009/0087 ,  A61F2009/00872

    摘要： A device for generating at least one continuous slit-like incision (42) from the posterior surface (48) as far as the anterior surface (46) of the cornea (44) of an eye, comprising a laser device for generating at least one part of the incision with focused pulsed laser radiation, the laser device including controllable components for setting the location of the focus, a control computer for controlling these components, and also a control program for the control computer. The control program contains instructions that are designed to bring about, upon execution by the control computer, the generation of at least one part of the incision (42) originating from the posterior surface (48) of the cornea, the cross-sectional contour of the incision—when observed in the direction from the anterior surface to the posterior surface—deviating from a straight line (60) perpendicular to the surface of the eye.

    摘要翻译： 一种用于从后表面（48）产生至少一个连续的狭缝状切口（42）的器件，其直到眼睛的角膜（44）的前表面（46），包括用于产生至少一个 具有聚焦脉冲激光辐射的切口的一部分，激光装置包括用于设置焦点位置的可控组件，用于控制这些部件的控制计算机，以及用于控制计算机的控制程序。 该控制程序包含指令，其被设计成在由控制计算机执行时产生源自角膜的后表面（48）的切口（42）的至少一部分，横截面轮廓 当从前表面到后表面的方向观察时，该切口偏离垂直于眼睛表面的直线（60）。

    DEVICE FOR LASER-AIDED EYE SURGERY
    7.
    发明申请
    DEVICE FOR LASER-AIDED EYE SURGERY 审中-公开
    激光眼科手术装置

    公开(公告)号：US20130296834A1

    公开(公告)日：2013-11-07

    申请号：US13872697

    申请日：2013-04-29

    申请人： WAVELIGHT GMBH ,  ARMIN WELLHÖFER ,  CHRISTOF DONITZKY ,  JOHANNES KRAUSE

    发明人： Armin Wellhöfer ,  Christof Donitzky ,  Johannes Krause

    IPC分类号： A61F9/008

    CPC分类号： A61F9/00814 ,  A61F9/00804 ,  A61F9/00836 ,  A61F9/0084 ,  A61F9/009 ,  A61F2009/00846 ,  A61F2009/00872

    摘要： A device for laser-aided eye surgery comprising a patient table, as well as at least one laser system with a laser treatment head for emission of a focused laser beam onto an eye of a patient to be treated on the table. The laser system comprises an operation microscope with a viewing beam path running collinear to the laser beam path at least in the area of the emission location of the laser beam. According to the invention, the device is characterized by at least a first camera to create an image at least comprising the area from the mouth to the forehead of a patient lying on a table, as well as by a display device to display the picture taken. As an alternative to, or in addition to, the first camera and the display device, the eye-surgery device can comprise a laser projector for projection of a laser light pattern onto the patient's body as well as a guiding computer controlling the projector with an image signal output to which an image signal input of the projector is attached.

    摘要翻译： 一种用于激光辅助眼科手术的装置，包括患者台，以及至少一个具有激光治疗头的激光系统，用于将聚焦的激光束发射到待处理的患者的眼睛上。 激光系统包括至少在激光束的发射位置的区域中具有与激光束路径共线运行的观察光束路径的操作显微镜。 根据本发明，该装置的特征在于至少一个第一照相机，用于创建至少包括从躺在桌子上的患者的口部到前额的区域以及通过显示装置显示所拍照片的区域的图像 。 作为第一相机和显示装置的替代或补充，眼科手术装置可以包括用于将激光图案投影到患者身体上的激光投影仪以及控制投影仪的引导计算机 连接有投影仪输入的图像信号的图像信号输出。

    Technique for laser-cutting an endothelial corneal graft
    9.
    发明授权
    Technique for laser-cutting an endothelial corneal graft 有权

    公开(公告)号：US10085887B2

    公开(公告)日：2018-10-02

    申请号：US14440591

    申请日：2013-10-28

    申请人： WAVELIGHT GMBH

    发明人： Christof Donitzky ,  Theo Seiler

    IPC分类号： A61F9/008

    摘要： A method for preparing an endothelial corneal graft is provided. The method comprises: providing a donor cornea; irradiating the donor cornea from an endothelial side thereof with laser radiation to cause a photodisruption in tissue of the donor cornea at a focal point of the radiation; and moving the focal point of the radiation to form an endothelial graft in the donor cornea. By irradiating the donor cornea from the endothelial side thereof, instead of the epithelial side, to cut the endothelial graft, optical inhomogeneities which may develop after death in stromal tissue of the donor cornea leave the laser cutting process substantially unaffected.