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公开(公告)号：US20220162598A1
公开(公告)日：2022-05-26
申请号：US16869126
申请日：2020-05-07
发明人： Chandra Vargeese , Meena , Nenad Svrzikapa , Susovan Mohapatra , Christopher J. Francis , Gregory L. Verdine , Anna Sokolovska
IPC分类号： C12N15/11 , C12N15/113
摘要： Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer. In some embodiments, a chirally controlled oligonucleotide composition has any sequence of bases, and/or pattern or base modifications, sugar modifications, backbone modifications and/or stereochemistry, or combination of these elements, described herein.
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公开(公告)号：US20210130821A1
公开(公告)日：2021-05-06
申请号：US16717986
申请日：2019-12-17
发明人： David Charles Donnell Butler , Naoki Iwamoto , Meena . , Nenad Svrzikapa , Gregory L. Verdine , Ivan Zlatev
IPC分类号： C12N15/113 , C07H21/00 , C07C317/28 , C07D295/088 , C12N15/11 , C12Q1/6876
摘要： The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.
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公开(公告)号：US20200056173A1
公开(公告)日：2020-02-20
申请号：US16098836
申请日：2017-05-03
发明人： Chandra Vargeese , Meena . , Nenad Svrzikapa , Susovan Mohapatra , Christopher J. Francis , Gregory L. Verdine , Anna Sokolovska
IPC分类号： C12N15/11 , C12N15/113
摘要： Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer. In some embodiments, a chirally controlled oligonucleotide composition has any sequence of bases, and/or pattern or base modifications, sugar modifications, backbone modifications and/or stereochemistry, or combination of these elements, described herein.
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公开(公告)号：US09885037B2
公开(公告)日：2018-02-06
申请号：US14414614
申请日：2013-07-12
发明人： David Butler , Naoki Iwamoto , Meena , Nenad Svrzikapa , Gregory L. Verdine , Ivan Zlatev
IPC分类号： C07H21/04 , C12N15/113 , C07H21/00 , C07C317/28 , C07D295/088 , C12Q1/68 , C12N15/11
摘要： The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.
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公开(公告)号：US10590413B2
公开(公告)日：2020-03-17
申请号：US15462787
申请日：2017-03-17
发明人： David Charles Donnell Butler , Naoki Iwamoto , Meena , Nenad Svrzikapa , Gregory L. Verdine , Ivan Zlatev
IPC分类号： C12N15/113 , C07H21/00 , C07C317/28 , C07D295/088 , C12N15/11 , C12Q1/6876
摘要： The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.
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公开(公告)号：US10479995B2
公开(公告)日：2019-11-19
申请号：US15746220
申请日：2016-07-22
发明人： Chandra Vargeese , Meena , Nenad Svrzikapa , Susovan Mohapatra , Christopher J. Francis , Gregory L. Verdine , Anna Sokolovska
IPC分类号： C12N15/113 , C12N15/115 , A61P25/28
摘要： Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer. In some embodiments, a chirally controlled oligonucleotide composition has any sequence of bases, and/or pattern or base modifications, sugar modifications, backbone modifications and/or stereochemistry, or combination of these elements, described herein.
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公开(公告)号：US10160969B2
公开(公告)日：2018-12-25
申请号：US15112146
申请日：2015-01-16
发明人： Meena , David Butler , Naoki Iwamoto , Nenad Svrzikapa , Gregory L. Verdine , Ivan Zlatev
IPC分类号： C12N15/113
摘要： The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer.
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公开(公告)号：US20170275621A1
公开(公告)日：2017-09-28
申请号：US15462787
申请日：2017-03-17
发明人： David Charles Donnell Butler , Naoki Iwamoto , Meena . , Nenad Svrzikapa , Gregory L. Verdine , Ivan Zlatev
IPC分类号： C12N15/113 , C07D295/088 , C07H21/00 , C12Q1/68 , C07C317/28 , C12N15/11
CPC分类号： C12N15/113 , C07C317/28 , C07D295/088 , C07H21/00 , C12N15/11 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2330/30 , C12Q1/6876
摘要： The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.
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公开(公告)号：US11643657B2
公开(公告)日：2023-05-09
申请号：US16717986
申请日：2019-12-17
发明人： David Charles Donnell Butler , Naoki Iwamoto , Meena , Nenad Svrzikapa , Gregory L. Verdine , Ivan Zlatev
IPC分类号： C12N15/113 , C07H21/00 , C07C317/28 , C07D295/088 , C12N15/11 , C12Q1/6876
CPC分类号： C12N15/113 , C07C317/28 , C07D295/088 , C07H21/00 , C12N15/11 , C12Q1/6876 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2330/30
摘要： The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.
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公开(公告)号：US10724035B2
公开(公告)日：2020-07-28
申请号：US16098836
申请日：2017-05-03
发明人： Chandra Vargeese , Meena , Nenad Svrzikapa , Susovan Mohapatra , Christopher J. Francis , Gregory L. Verdine , Anna Sokolovska
IPC分类号： A61K31/712 , A61K31/7125 , C12N15/11 , C12N15/113
摘要： Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer. In some embodiments, a chirally controlled oligonucleotide composition has any sequence of bases, and/or pattern or base modifications, sugar modifications, backbone modifications and/or stereochemistry, or combination of these elements, described herein.
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