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1.发明公开公开(公告)号：US20240299076A1
公开(公告)日：2024-09-12
申请号：US18608958
申请日：2024-03-19
CPC分类号： A61B18/1233 , A61B2017/00159 , A61B2017/00172 , A61B2017/0019 , A61B2018/00577 , A61B2018/00613 , A61B2018/00732 , A61B2018/00767 , A61B2018/1253 , A61B2018/126 , A61B2018/1467 , A61B18/1477 , A61B2090/0409 , A61N1/327
摘要： Methods and systems for distributing electrical energy to tissue which minimize Joule heating, thermal effects, and/or thermal damage, without sacrificing efficacy of treatment, are described. The methods and systems are particularly suitable to electrical energy-based therapies employing multiple electrodes, such as arrays of electrodes.
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2.发明公开公开(公告)号：US20240173063A1
公开(公告)日：2024-05-30
申请号：US18528051
申请日：2023-12-04
发明人： Robert Neal, II , Rafael V. Davalos
CPC分类号： A61B18/1206 , A61B18/14 , A61B18/1477 , A61B18/18 , A61B34/10 , C12N13/00 , A61B2018/0016 , A61B2018/00577 , A61B2018/00613 , A61B2018/00666 , A61B2018/00672 , A61B2018/00678 , A61B2018/00767 , A61B2018/00875 , A61B2018/1425 , A61B2034/104
摘要： A medical system for ablating a tissue site with real-time monitoring during an electroporation treatment procedure. A pulse generator generates a pre-treatment (PT) test signal prior to the treatment procedure and intra-treatment (IT) test signals during the treatment procedure. A treatment control module determines impedance values from the PT test signal and IT test signals and determines a progress of electroporation and an end point of treatment in real-time based on the determined impedance values while the treatment progresses.
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公开(公告)号：US20240008911A1
公开(公告)日：2024-01-11
申请号：US18348605
申请日：2023-07-07
CPC分类号： A61B18/1206 , A61B18/14 , A61B18/1477 , A61N1/327 , C12N13/00 , A61B2018/00446
摘要： Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body.
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公开(公告)号：US11519877B2
公开(公告)日：2022-12-06
申请号：US16058478
申请日：2018-08-08
IPC分类号： B03C5/00 , B03C5/02 , G01N27/447 , B01D57/02
摘要： Devices and methods for performing dielectrophoresis are described. The devices contain sample channel which is separated by physical barriers from electrode channels which receive electrodes. The devices and methods may be used for the separation and analysis of particles in solution, including the separation and isolation of cells of a specific type. As the electrodes do not make contact with the sample, electrode fouling is avoided and sample integrity is better maintained.
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公开(公告)号：US11453873B2
公开(公告)日：2022-09-27
申请号：US16535451
申请日：2019-08-08
发明人： Rafael V. Davalos , Paulo A. Garcia , John H. Rossmeisl , John L. Robertson , Robert E. Neal, II
摘要： The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
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公开(公告)号：US11272979B2
公开(公告)日：2022-03-15
申请号：US16152743
申请日：2018-10-05
摘要： Systems and methods are provided for modeling and for providing a graphical representation of tissue heating and electric field distributions for medical treatment devices that apply electrical treatment energy through one or a plurality of electrodes. In embodiments, methods comprise: providing one or more parameters of a treatment protocol for delivering one or more electrical pulses to tissue through a plurality of electrodes; modeling electric and heat distribution in the tissue based on the parameters; and displaying a graphical representation of the modeled electric and heat distribution. In another embodiment, a treatment planning module is adapted to generate an estimated target ablation zone based on a combination of one or more parameters for an irreversible electroporation protocol and one or more tissue-specific conductivity parameters.
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公开(公告)号：US20210393312A1
公开(公告)日：2021-12-23
申请号：US17277662
申请日：2019-09-18
发明人： Rafael V. Davalos , Natalie White
IPC分类号： A61B18/12
摘要： Described herein are methods and systems of performing immunotherapy on a subject and/or determining if a subject will be responsive to ablation immunotherapy.
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8.发明申请公开(公告)号：US20200260987A1
公开(公告)日：2020-08-20
申请号：US16865031
申请日：2020-05-01
发明人： Rafael V. Davalos , Mohammad Bonakdar , Eduardo L. Latouche , Roop L. Mahajan , John L. Robertson , Christopher B. Arena , Michael B. Sano
IPC分类号： A61B5/053
摘要： Provided herein are devices, systems, and methods for monitoring lesion or treated area in a tissue during focal ablation or cell membrane disruption therapy.
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公开(公告)号：US10471254B2
公开(公告)日：2019-11-12
申请号：US15310114
申请日：2015-05-12
申请人： Virginia Tech Intellectual Properties, Inc. , Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
IPC分类号： A61B18/14 , A61N1/32 , A61N1/40 , A61B90/00 , A61B18/12 , A61N1/06 , A61N1/08 , A61B18/00 , A61B17/00
摘要： A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive pulses is optimized to produce effects on intracellular membrane potentials. Therapies based on the system and method produce two treatment zones: an ablation zone surrounding the electrodes within which aberrant cells are non-selectively killed and a selective treatment zone surrounding the ablation zone within which target cells are selectively killed through effects on intracellular membrane potentials. As a result, infiltrating tumor cells within a tumor margin can be effectively treated while sparing healthy tissue. The system and method are useful for treating various cancers in which solid tumors form and have a chance of recurrence from microscopic disease surrounding the tumor.
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公开(公告)号：US20190175260A1
公开(公告)日：2019-06-13
申请号：US16275429
申请日：2019-02-14
发明人： Rafael V. Davalos , Paulo A. Garcia , John L. Robertson , John H. Rossmeisl , Robert E. Neal, II
摘要： The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
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