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公开(公告)号：US20160022664A2
公开(公告)日：2016-01-28
申请号：US14629097
申请日：2015-02-23
发明人： Fredrick F. Van Goor , Rossitza Gueorguieva Alargova , Tim Edward Alcacio , Hayley Marie Binch , Martyn Curtis Botfield , Lev Tyler Dewey Fanning , Peter Diederik Jan Grootenhuis , Dennis James Hurley , Irina Nikolaevna Kadiyala , Ritu Rohit Kaushik , Ali Keshavarz-Shokri , Mariusz Krawiec , Elaine Chungmin Lee , Brian Luisi , Ales Medek , Mehdi Numa , Urvi Jagdishbhai Sheth , Alina Silina , Marinus Jacobus Verwijs , Xiaoqing Yang , Christopher Ryan Young , Noreen Tasneem Zaman , Beili Zhang , Yuegang Zhang , Gregor Zlokarnik
IPC分类号： A61K31/4709 , A61K31/404 , C12Q1/34 , A61K31/443
CPC分类号： A61K31/4709 , A61K31/404 , A61K31/443 , A61K31/4704 , A61K45/06 , C07D405/12 , C12Q1/34 , G01N2500/04 , G01N2500/20 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.
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公开(公告)号：US20160022665A2
公开(公告)日：2016-01-28
申请号：US14630778
申请日：2015-02-25
发明人： Fredrick F. Van Goor , Rossitza Gueorguieva Alargova , Tim Edward Alcacio , Sneha G. Arekar , Hayley Marie Binch , Martyn Curtis Botfield , Lev Tyler Dewey Fanning , Peter Diederik Jan Grootenhuis , Dennis James Hurley , Steven C. Johnston , Irina Nikolaevna Kadiyala , Ritu Rohit Kaushik , Ali Keshavarz-Shokri , Mariusz Krawiec , Elaine Chungmin Lee , Brian Luisi , Ales Medek , Praveen Mudunuri , Mehdi Numa , Urvi Jagdishbhai Sheth , Alina Silina , Mark Jeffrey Sullivan , Marinus Jacobus Verwijs , Xiaoqing Yang , Christopher Ryan Young , Noreen Tasneem Zaman , Beili Zhang , Yuegang Zhang , Gregor Zlokarnik
IPC分类号： A61K31/4709 , G01N33/68 , A61K31/404 , A61K31/47 , A61K31/443
CPC分类号： A61K31/4709 , A61K31/404 , A61K31/443 , A61K31/4433 , A61K31/47 , A61K31/4704 , G01N33/6872 , G01N2333/4703 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising a compound of Formulas I and II, optionally in combination with a Compound of Formula III and/or a Compound of Formula IV. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.
摘要翻译： 本发明涉及包含式I和II化合物，任选与式III化合物和/或式IV化合物组合的药物组合物。 本发明还涉及固体形式及其药物制剂，以及使用这些组合物治疗CFTR介导的疾病，特别是囊性纤维化的方法。
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公开(公告)号：US20130131107A1
公开(公告)日：2013-05-23
申请号：US13657345
申请日：2012-10-22
发明人： Fredrick F. Van Goor , Rossitza Gueorguieva Alargova , Tim Edward Alcacio , Sneha G. Arekar , Hayley Marie Binch , Martyn Curtis Botfield , Lev Tyler Dewey Fanning , Peter Diederik Jan Grootenhuis , Dennis James Hurley , Steven C. Johnston , Irina Nikolaevna Kadiyala , Ritu Rohit Kaushik , Ali Keshavarz-Shokri , Mariusz Krawiec , Elaine Chungmin Lee , Brian Luisi , Ales Medek , Praveen Mudunuri , Mehdi Numa , Urvi Jagdishbhai Sheth , Alina Silina , Mark Jeffrey Sullivan , Marinus Jacobus Verwijs , Xiaoqing Yang , Christopher Ryan Young , Noreen Tasneem Zaman , Beili Zhang , Yuegang Zhang , Gregor Zlokarnik
IPC分类号： A61K31/47 , A61K31/404 , A61K31/443
CPC分类号： A61K31/4709 , A61K31/404 , A61K31/443 , A61K31/4433 , A61K31/47 , A61K31/4704 , G01N33/6872 , G01N2333/4703 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising a compound of Formulas I and II, optionally in combination with a Compound of Formula III and/or a Compound of Formula IV. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.
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公开(公告)号：US20150164881A1
公开(公告)日：2015-06-18
申请号：US14629097
申请日：2015-02-23
发明人： Fredrick F. Van Goor , Rossitza Gueorguieva Alargova , Tim Edward Alcacio , Hayley Marie Binch , Martyn Curtis Botfield , Lev Tyler Dewey Fanning , Peter Diederik Jan Grootenhuis , Dennis James Hurley , Irina Nikolaevna Kadiyala , Ritu Rohit Kaushik , Ali Keshavarz-Shokri , Mariusz Krawiec , Elaine Chungmin Lee , Brian Luisi , Ales Medek , Mehdi Numa , Urvi Jagdishbhai Sheth , Alina Silina , Marinus Jacobus Verwijs , Xiaoqing Yang , Christopher Ryan Young , Noreen Tasneem Zaman , Beili Zhang , Yuegang Zhang , Gregor Zlokarnik
IPC分类号： A61K31/4709 , A61K31/404 , C12Q1/34 , A61K31/443
CPC分类号： A61K31/4709 , A61K31/404 , A61K31/443 , A61K31/4704 , A61K45/06 , C07D405/12 , C12Q1/34 , G01N2500/04 , G01N2500/20 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.
摘要翻译： 本发明涉及药物组合物，其包含与式II化合物和/或式III化合物中的一种或两种结合的式I化合物。 本发明还涉及固体形式及其药物制剂，以及使用这些组合物治疗CFTR介导的疾病，特别是囊性纤维化的方法。
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5.发明申请公开(公告)号：US20150025073A1
公开(公告)日：2015-01-22
申请号：US14454227
申请日：2014-08-07
发明人： Sara Sabina Hadida-Ruah , Hayley Marie Binch , Michael Paul DeNinno , Lev Tyler Dewey Fanning , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Nicole Hilgraf , Pramod Joshi , Edward Adam Kallel , Mark Thomas Miller , Joseph Pontillo , Alina Silina , Urvi Jagdishbhai Sheth , Dennis James Hurley , Vijayalaksmi ARUMUGAM
IPC分类号： C07D498/10
CPC分类号： C07D498/10
摘要： The invention relates to morpholine spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的吗啉螺环哌啶酰胺化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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6.发明授权公开(公告)号：US09181273B2
公开(公告)日：2015-11-10
申请号：US14454227
申请日：2014-08-07
发明人： Sara Sabina Hadida-Ruah , Hayley Marie Binch , Michael Paul DeNinno , Lev Tyler Dewey Fanning , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Nicole Hilgraf , Pramod Joshi , Edward Adam Kallel , Mark Thomas Miller , Joseph Pontillo , Alina Silina , Urvi Jagdishbhai Sheth , Dennis James Hurley , Vijayalaksmi Arumugam
IPC分类号： C07D498/10
CPC分类号： C07D498/10
摘要： The invention relates to morpholine spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的吗啉螺环哌啶酰胺化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20150164883A1
公开(公告)日：2015-06-18
申请号：US14630778
申请日：2015-02-25
发明人： Fredrick F. Van Goor , Rossitza Gueorguieva Alargova , Tim Edward Alcacio , Sneha G. Arekar , Hayley Marie Binch , Martyn Curtis Botfield , Lev Tyler Dewey Fanning , Peter Diederik Jan Grootenhuis , Dennis James Hurley , Steven C. Johnston , Irina Nikolaevna Kadiyala , Ritu Rohit Kaushik , Ali Keshavarz-Shokri , Mariusz Krawiec , Elaine Chungmin Lee , Brian Luisi , Ales Medek , Praveen Mudunuri , Mehdi Numa , Urvi Jagdishbhai Sheth , Alina Silina , Mark Jeffrey Sullivan , Marinus Jacobus Verwijs , Xiaoqing Yang , Christopher Ryan Young , Noreen Tasneem Zaman , Beili Zhang , Yuegang Zhang , Gregor Zlokmik
IPC分类号： A61K31/4709 , G01N33/68 , A61K31/404 , A61K31/47 , A61K31/443
CPC分类号： A61K31/4709 , A61K31/404 , A61K31/443 , A61K31/4433 , A61K31/47 , A61K31/4704 , G01N33/6872 , G01N2333/4703 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising a compound of Formulas I and II, optionally in combination with a Compound of Formula III and/or a Compound of Formula IV. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.
摘要翻译： 本发明涉及包含式I和II化合物，任选与式III化合物和/或式IV化合物组合的药物组合物。 本发明还涉及固体形式及其药物制剂，以及使用这些组合物治疗CFTR介导的疾病，特别是囊性纤维化的方法。
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公开(公告)号：US20140113005A1
公开(公告)日：2014-04-24
申请号：US13742948
申请日：2013-01-16
发明人： Jean-Damien Charrier , Steven John Durrant , David Kay , Michael O'Donnell , Ronald Marcellus Alphonsus Knegtel , Somhairle MacCormick , Joanne Pinder , Stephen Clinton Young , Haley Marie Binch , Thomas Cleveland , Lev Tyler Dewey Fanning , Dennis James Hurley , Pramod Joshi , Urvi Jagdishbhai Sheth , Alina Silina , Philip Michael Reaper , Anisa Nizarali Virani
IPC分类号： C07D403/14 , A61K31/497 , C07D403/04 , A61K31/541 , C07D417/14 , A61K45/06 , C07D413/04 , C07D241/28 , C07D405/14 , C07D471/04 , C07D491/113 , C07D409/04 , A61K31/551 , C07D417/04
CPC分类号： C07D403/14 , A61K31/497 , A61K31/541 , A61K31/551 , A61K45/06 , C07D241/28 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/113
摘要： The present disclosure relates to pyrazine compounds of formula I: wherein L, n, R1, and R2 are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmaceutically acceptable compositions comprising the compounds of the disclosure; methods of treating of various diseases, disorders, and conditions using the compounds of the disclosure; processes for preparing the compounds of the disclosure; intermediates for the preparation of the compounds of the disclosure; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.
摘要翻译： 本公开涉及式I的吡嗪化合物：其中L，n，R 1和R 2如说明书中所述。 这些化合物可用作ATR蛋白激酶的抑制剂。 本公开还涉及包含本公开内容的化合物的药学上可接受的组合物; 使用本公开的化合物治疗各种疾病，病症和病症的方法; 制备本公开的化合物的方法; 用于制备本公开的化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。
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公开(公告)号：US20130158071A1
公开(公告)日：2013-06-20
申请号：US13657299
申请日：2012-10-22
发明人： Fredrick F. Van Goor , Rossitza Gueorguieva Alargova , Tim Edward Alcacio , Hayley Marie Binch , Martyn Curtis Botfield , Lev Tyler Dewey Fanning , Peter Diederik Jan Grootenhuis , Dennis James Hurley , Irina Nikolaevna Kadiyala , Ritu Rohit Kaushik , Ali Keshavarz-Shokri , Mariusz Krawiec , Elaine Chungmin Lee , Brian Luisi , Ales Medek , Mehdi Numa , Urvi Jagdishbhai Sheth , Alina Silina , Marinus Jacobus Verwijs , Xiaoqing Yang , Christopher Ryan Young , Noreen Tasneem Zaman , Beili Zhang , Yuegang Zhang , Gregor Zlokarnik
IPC分类号： A61K31/4709 , A61K31/404 , A61K31/443
CPC分类号： A61K31/4709 , A61K31/404 , A61K31/443 , A61K31/4704 , A61K45/06 , C07D405/12 , C12Q1/34 , G01N2500/04 , G01N2500/20 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.
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