公开(公告)号：US10039761B2

公开(公告)日：2018-08-07

申请号：US15130266

申请日：2016-04-15

申请人： Vertex Pharmaceuticals Incorporated

发明人： Kwame Wiredu Nti-Addae ,  Simon Adam O'Neil ,  Yuegang Zhang ,  Michael Waldo ,  Praveen Mudunuri ,  Bin Song ,  John Gregg Van Alsten ,  Mark Strohmeier ,  Kathy Stavropoulos ,  Irina Nikolaevna Kadiyala ,  Mettachit Navamal

IPC分类号： A61K31/33 ,  A61K31/506 ,  C07D401/14 ,  A61K31/337 ,  A61K31/5025 ,  A61K31/513 ,  A61K31/517 ,  A61K31/555 ,  A61K31/704 ,  A61K31/7048 ,  A61K33/24 ,  A61K38/14 ,  A61K39/395 ,  A61K45/06 ,  C07B59/00 ,  C07C55/10 ,  C07C55/14 ,  C07C57/145 ,  C07C57/15 ,  C07C59/265 ,  C07C63/08 ,  C07K16/28 ,  A61N5/10

CPC分类号： A61K31/506 ,  A61K31/337 ,  A61K31/5025 ,  A61K31/513 ,  A61K31/517 ,  A61K31/555 ,  A61K31/704 ,  A61K31/7048 ,  A61K33/24 ,  A61K38/14 ,  A61K39/39558 ,  A61K45/06 ,  A61N2005/1098 ,  A61P35/00 ,  C07B59/002 ,  C07B2200/05 ,  C07B2200/13 ,  C07C55/10 ,  C07C55/14 ,  C07C57/145 ,  C07C57/15 ,  C07C59/265 ,  C07C63/08 ,  C07D401/14 ,  C07K16/2863 ,  C07K2317/24

摘要： The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.

公开(公告)号：US10716789B2

公开(公告)日：2020-07-21

申请号：US16038696

申请日：2018-07-18

申请人： Vertex Pharmaceuticals Incorporated

发明人： Kwame Wiredu Nti-Addae ,  Simon Adam O'Neil ,  Yuegang Zhang ,  Michael P. Waldo ,  Praveen Mudunuri ,  Bin Song ,  John Gregg Van Alsten ,  Mark Strohmeier ,  Kathy Stavropoulos ,  Irina Nikolaevna Kadiyala ,  Mettachit Navamal

IPC分类号： A61K31/506 ,  C07D401/14 ,  A61P35/00 ,  A61K31/337 ,  A61K31/5025 ,  A61K31/513 ,  A61K31/517 ,  A61K31/555 ,  A61K31/704 ,  A61K31/7048 ,  A61K33/24 ,  A61K38/14 ,  A61K39/395 ,  A61K45/06 ,  C07B59/00 ,  C07C55/10 ,  C07C55/14 ,  C07C57/145 ,  C07C57/15 ,  C07C59/265 ,  C07C63/08 ,  C07K16/28 ,  A61N5/10

摘要： The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.

公开(公告)号：US20160339024A1

公开(公告)日：2016-11-24

申请号：US15130266

申请日：2016-04-15

申请人： Vertex Pharmaceuticals Incorporated

发明人： Kwame Wiredu Nti-Addae ,  Simon Adam O'Neil ,  Yuegang Zhang ,  Michael Waldo ,  Praveen Mudunuri ,  Bin Song ,  John Gregg Van Alsten ,  Mark Strohmeier ,  Kathy Stavropoulos ,  Irina Nikolaevna Kadiyala ,  Mettachit Navamal

IPC分类号： A61K31/506 ,  C07D401/14 ,  C07B59/00 ,  C07C55/14 ,  C07C55/10 ,  C07C57/145 ,  C07C57/15 ,  C07C59/265 ,  C07C63/08 ,  A61K31/337 ,  A61K31/555 ,  A61K31/517 ,  A61K31/7048 ,  A61K31/704 ,  A61K38/14 ,  A61K31/5025 ,  A61K33/24 ,  A61K31/513 ,  A61K39/395 ,  C07K16/28 ,  A61K45/06

CPC分类号： A61K31/506 ,  A61K31/337 ,  A61K31/5025 ,  A61K31/513 ,  A61K31/517 ,  A61K31/555 ,  A61K31/704 ,  A61K31/7048 ,  A61K33/24 ,  A61K38/14 ,  A61K39/39558 ,  A61K45/06 ,  A61N2005/1098 ,  C07B59/002 ,  C07B2200/05 ,  C07B2200/13 ,  C07C55/10 ,  C07C55/14 ,  C07C57/145 ,  C07C57/15 ,  C07C59/265 ,  C07C63/08 ,  C07D401/14 ,  C07K16/2863 ,  C07K2317/24

摘要： The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.

摘要翻译： 其中R1和R2各自为H或2H，选自己二酸，柠檬酸，富马酸，马来酸，琥珀酸或苯甲酸的共晶体形成剂。 在本发明的范围内也是制造和使用本发明的方法。

公开(公告)号：US11623924B2

公开(公告)日：2023-04-11

申请号：US16593118

申请日：2019-10-04

申请人： Vertex Pharmaceuticals Incorporated

发明人： Upul Keerthi Bandarage ,  Cavan McKeon Bligh ,  Michael John Boyd ,  Diane M. Boucher ,  Michael Aaron Brodney ,  Veronique Damagnez ,  Lev Tyler Dewey Fanning ,  Mary Elizabeth Eccles ,  Robert Francis Fimognari, Jr. ,  Kevin James Gagnon ,  Pedro M. Garcia Barrantes ,  Simon Giroux ,  Ronald Lee Grey, Jr. ,  Amy Beth Hall ,  Sarah Carol Hood ,  Dennis James Hurley ,  Joshua Kennedy Hussey ,  Mac Arthur Johnson, Jr. ,  Peter Jones ,  Sarathy Kesavan ,  Adam Looker ,  Brad D. Maxwell ,  John Patrick Maxwell ,  Ales Medek ,  Mettachit Navamal ,  Philippe Marcel Nuhant ,  Setu Roday ,  Stefanie Roeper ,  Rupa Sawant ,  Yi Shi ,  Rebecca Jane Swett ,  Qing Tang ,  Timothy Lewis Tapley ,  Stephen A. Thomson ,  Michael Waldo ,  Jinwang Xu ,  Kevin Michael Cottrell

IPC分类号： C07D403/04 ,  C07D519/00

摘要： Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

公开(公告)号：US20180325897A1

公开(公告)日：2018-11-15

申请号：US16038696

申请日：2018-07-18

申请人： Vertex Pharmaceuticals Incorporated

发明人： Kwame Wiredu Nti-Addae ,  Simon Adam O'Neil ,  Yuegang Zhang ,  Michael Waldo ,  Praveen Mudunuri ,  Bin Song ,  John Gregg Van Alsten ,  Mark Strohmeier ,  Kathy Stavropoulos ,  Irina Nikolaevna Kadiyala ,  Mettachit Navamal

IPC分类号： A61K31/506 ,  C07K16/28 ,  A61K31/5025 ,  A61K31/513 ,  A61K31/517 ,  A61K31/337 ,  C07D401/14 ,  C07C63/08 ,  C07C59/265 ,  C07C57/15 ,  C07C57/145 ,  C07C55/14 ,  C07C55/10 ,  C07B59/00 ,  A61K45/06 ,  A61K39/395 ,  A61K38/14 ,  A61K33/24 ,  A61K31/7048 ,  A61K31/704 ,  A61K31/555 ,  A61N5/10

摘要： The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.