- 专利标题： Co-crystals and pharmaceutical compositions comprising the same
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申请号： US15130266申请日： 2016-04-15
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公开(公告)号： US10039761B2公开(公告)日： 2018-08-07
- 发明人: Kwame Wiredu Nti-Addae , Simon Adam O'Neil , Yuegang Zhang , Michael Waldo , Praveen Mudunuri , Bin Song , John Gregg Van Alsten , Mark Strohmeier , Kathy Stavropoulos , Irina Nikolaevna Kadiyala , Mettachit Navamal
- 申请人： Vertex Pharmaceuticals Incorporated
- 申请人地址： US MA Boston
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： US MA Boston
- 代理机构： Dechert LLP
- 代理商 Andrea L. C. Reid
- 主分类号： A61K31/33
- IPC分类号： A61K31/33 ; A61K31/506 ; C07D401/14 ; A61K31/337 ; A61K31/5025 ; A61K31/513 ; A61K31/517 ; A61K31/555 ; A61K31/704 ; A61K31/7048 ; A61K33/24 ; A61K38/14 ; A61K39/395 ; A61K45/06 ; C07B59/00 ; C07C55/10 ; C07C55/14 ; C07C57/145 ; C07C57/15 ; C07C59/265 ; C07C63/08 ; C07K16/28 ; A61N5/10
摘要：
The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.
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