公开(公告)号：US12173324B2

公开(公告)日：2024-12-24

申请号：US17988257

申请日：2022-11-16

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： George Harb ,  Chunhui Xie

IPC: C12N5/071 ,  A61K35/39

Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.

公开(公告)号：US20230092449A1

公开(公告)日：2023-03-23

申请号：US17988257

申请日：2022-11-16

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： George Harb ,  Chunhui Xie

IPC: C12N5/071 ,  A61K35/39

Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.

公开(公告)号：US20240382532A1

公开(公告)日：2024-11-21

申请号：US18647137

申请日：2024-04-26

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： George Harb ,  Chunhui Xie ,  Bryce W. Carey ,  Aleksander Szymaniak ,  Christopher Thanos ,  Evrett Thompson ,  Rebecca Chinn ,  Suyash Raj

IPC: A61K35/39 ,  A61K38/28 ,  A61P3/10 ,  C12N5/071

Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.

公开(公告)号：US12049645B2

公开(公告)日：2024-07-30

申请号：US17390839

申请日：2021-07-30

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： George Harb ,  Chunhui Xie

IPC: C12N5/071 ,  A61K35/39

CPC classification number: C12N5/0676 ,  A61K35/39 ,  C12N2501/11 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/415

Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.

公开(公告)号：US11992506B2

公开(公告)日：2024-05-28

申请号：US18051721

申请日：2022-11-01

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： George Harb ,  Chunhui Xie ,  Bryce W. Carey ,  Aleksander Szymaniak ,  Christopher Thanos ,  Evrett Thompson ,  Rebecca Chinn ,  Suyash Raj

IPC: A61K9/00 ,  A61K35/39 ,  A61K38/28 ,  A61P3/10 ,  C12N5/071

CPC classification number: A61K35/39 ,  A61K38/28 ,  A61P3/10 ,  C12N5/0676 ,  C12N2501/115 ,  C12N2501/117 ,  C12N2501/16 ,  C12N2506/45

Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.

公开(公告)号：US20230218676A1

公开(公告)日：2023-07-13

申请号：US18051721

申请日：2022-11-01

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： George Harb ,  Chunhui Xie ,  Bryce W. Carey ,  Aleksander Szymaniak ,  Christopher Thanos ,  Evrett Thompson ,  Rebecca Chinn ,  Suyash Raj

IPC: A61K35/39 ,  C12N5/071 ,  A61K38/28 ,  A61P3/10

CPC classification number: A61K35/39 ,  C12N5/0676 ,  A61K38/28 ,  A61P3/10 ,  C12N2506/45 ,  C12N2501/115 ,  C12N2501/117 ,  C12N2501/16

Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.

公开(公告)号：US20220090020A1

公开(公告)日：2022-03-24

申请号：US17390839

申请日：2021-07-30

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： George Harb ,  Chunhui Xie

IPC: C12N5/071 ,  A61K35/39

Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.