公开(公告)号：US11992506B2

公开(公告)日：2024-05-28

申请号：US18051721

申请日：2022-11-01

申请人： Vertex Pharmaceuticals Incorporated

发明人： George Harb ,  Chunhui Xie ,  Bryce W. Carey ,  Aleksander Szymaniak ,  Christopher Thanos ,  Evrett Thompson ,  Rebecca Chinn ,  Suyash Raj

IPC分类号： A61K9/00 ,  A61K35/39 ,  A61K38/28 ,  A61P3/10 ,  C12N5/071

CPC分类号： A61K35/39 ,  A61K38/28 ,  A61P3/10 ,  C12N5/0676 ,  C12N2501/115 ,  C12N2501/117 ,  C12N2501/16 ,  C12N2506/45

摘要： Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.

公开(公告)号：US20230218676A1

公开(公告)日：2023-07-13

申请号：US18051721

申请日：2022-11-01

申请人： Vertex Pharmaceuticals Incorporated

发明人： George Harb ,  Chunhui Xie ,  Bryce W. Carey ,  Aleksander Szymaniak ,  Christopher Thanos ,  Evrett Thompson ,  Rebecca Chinn ,  Suyash Raj

IPC分类号： A61K35/39 ,  C12N5/071 ,  A61K38/28 ,  A61P3/10

CPC分类号： A61K35/39 ,  C12N5/0676 ,  A61K38/28 ,  A61P3/10 ,  C12N2506/45 ,  C12N2501/115 ,  C12N2501/117 ,  C12N2501/16

摘要： Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.