公开(公告)号：US20240358767A1

公开(公告)日：2024-10-31

申请号：US18707756

申请日：2022-11-07

Applicant: VERTEX PHARMACEUTICALS INCORPORATED

Inventor： Chunhui XIE ,  George HARB ,  Elizabeth RYU ,  Nicholas TECENO ,  Christopher FARRAR

IPC: A61K35/39 ,  C12N5/071

CPC classification number: A61K35/39 ,  C12N5/0676 ,  C12N2501/117 ,  C12N2501/16 ,  C12N2501/385 ,  C12N2501/72

Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro in the presence of one or more chemical compounds that inhibit PI3K/Akt/mTOR signaling. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of making use thereof.

公开(公告)号：US20240271100A1

公开(公告)日：2024-08-15

申请号：US18018787

申请日：2021-07-30

Applicant: VERTEX PHARMACEUTICALS INCORPORATED

Inventor： George HARB ,  Chunhui XIE

IPC: C12N5/071

CPC classification number: C12N5/0677 ,  C12N2501/115 ,  C12N2506/45

Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic endocrine cells. In some aspects, the methods provided herein relate to generation of pancreatic β cell, α cell, δ cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.