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    Use of soluble pro(renin) receptor to treat metabolic disorders and related conditions
    2.
    发明授权
    Use of soluble pro(renin) receptor to treat metabolic disorders and related conditions 有权

    公开(公告)号：US11559563B2

    公开(公告)日：2023-01-24

    申请号：US16492457

    申请日：2018-03-14

    申请人： University of Utah Research Foundation

    发明人： Tianxin Yang

    IPC分类号： A61K38/00 ,  A61K38/17

    摘要： Disclosed are methods of treating obesity or an obesity-related condition comprising administering an effective amount of soluble (pro)renin receptor (sPRR) to a subject that is obese or having an obesity-related condition. In some instances, obesity-related conditions can be, but are not limited to, steatosis, hyperglycemia, insulin resistance, chronic renal disease. Disclosed are methods of reducing body weight comprising administering an effective amount of sPRR to a subject in need thereof. Disclosed are methods of treating fatty liver in a subject comprising administering an effective amount of sPRR to a subject in need thereof. Disclosed are methods of treating a fluid and electrolyte disorder comprising administering an effective amount of sPRR to a subject diagnosed with a fluid and electrolyte disorder.

    USE OF NITRATED LIPIDS FOR TREATMENT OF SIDE EFFECTS OF TOXIC MEDICAL THERAPIES
    4.
    发明申请
    USE OF NITRATED LIPIDS FOR TREATMENT OF SIDE EFFECTS OF TOXIC MEDICAL THERAPIES 有权
    使用硝酸脂治疗毒理疗法的副作用

    公开(公告)号：US20140256815A1

    公开(公告)日：2014-09-11

    申请号：US14205108

    申请日：2014-03-11

    申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION

    发明人： Tianxin Yang

    IPC分类号： A61K31/201

    CPC分类号： A61K31/201

    摘要： The present invention relates to methods of treating the side effects of a toxic medical therapy using nitrated lipids. In particular, the methods comprise the use of nitrated fatty acids or esters thereof to treat side effects, including organ system damage, caused by chemotherapy, radiotherapy, and the administration of other toxic agents.

    摘要翻译： 本发明涉及使用硝化脂质治疗有毒药物治疗副作用的方法。 特别地，所述方法包括使用硝化脂肪酸或其酯来治疗副作用，包括由化疗引起的器官系统损伤，放射治疗和其它毒性剂的施用。

    THE USE OF SOLUBLE PRO(RENIN) RECEPTOR TO TREAT METABOLIC DISORDERS AND RELATED CONDITIONS
    5.
    发明申请
    THE USE OF SOLUBLE PRO(RENIN) RECEPTOR TO TREAT METABOLIC DISORDERS AND RELATED CONDITIONS 有权

    公开(公告)号：US20210213098A1

    公开(公告)日：2021-07-15

    申请号：US16492457

    申请日：2018-03-14

    申请人： University of Utah Research Foundation

    发明人： Tianxin Yang

    IPC分类号： A61K38/17

    摘要： Disclosed are methods of treating obesity or an obesity-related condition comprising administering an effective amount of soluble (pro)renin receptor (sPRR) to a subject that is obese or having an obesity-related condition. In some instances, obesity-related conditions can be, but are not limited to, steatosis, hyperglycemia, insulin resistance, chronic renal disease. Disclosed are methods of reducing body weight comprising administering an effective amount of sPRR to a subject in need thereof. Disclosed are methods of treating fatty liver in a subject comprising administering an effective amount of sPRR to a subject in need thereof. Disclosed are methods of treating a fluid and electrolyte disorder comprising administering an effective amount of sPRR to a subject diagnosed with a fluid and electrolyte disorder.

    Combination therapy with nitrated lipids and inhibitors of the renin-angiotensin-aldosterone system
    6.
    发明授权
    Combination therapy with nitrated lipids and inhibitors of the renin-angiotensin-aldosterone system 有权
    用硝酸脂质和肾素 - 血管紧张素 - 醛固酮系统的抑制剂联合治疗

    公开(公告)号：US09192600B2

    公开(公告)日：2015-11-24

    申请号：US14183468

    申请日：2014-02-18

    申请人： The University of Utah Research Foundation

    发明人： Tianxin Yang

    IPC分类号： A61K31/41 ,  A61K31/4178 ,  A61K31/20 ,  A61K31/201 ,  A61K31/401 ,  A61K45/06

    CPC分类号： A61K31/4178 ,  A61K31/20 ,  A61K31/201 ,  A61K31/401 ,  A61K31/41 ,  A61K45/06 ,  A61K2300/00

    摘要： The present technology provides compositions and methods for treating chronic kidney disease, end-stage renal disease, or diabetic nephropathy. The compositions comprise a nitrated lipid and an inhibitor of the renin-angiotensin-aldosterone system. The methods comprise administering a nitrated lipid in combination with an inhibitor of the renin-angiotensin-aldosterone system to a subject in need thereof, in an amount effective to treat diabetic nephropathy, chronic kidney disease, and/or end-stage renal disease. The use of a nitrated lipid with an inhibitor of the renin-angiotensin-aldosterone system exhibits a synergistic effect in treating chronic kidney disease and diabetic nephropathy.

    摘要翻译： 本技术提供治疗慢性肾脏疾病，终末期肾病或糖尿病肾病的组合物和方法。 组合物包含硝化脂质和肾素 - 血管紧张素 - 醛固酮系统的抑制剂。 所述方法包括以有效治疗糖尿病肾病，慢性肾脏疾病和/或终末期肾病的量将有效的肾素 - 血管紧张素 - 醛固酮系统的抑制剂的硝化脂质施用于有需要的受试者。 使用含有肾素 - 血管紧张素 - 醛固酮系统抑制剂的硝化脂质对治疗慢性肾脏疾病和糖尿病肾病具有协同作用。

    Use of soluble pro(renin) receptor to treat metabolic disorders and related conditions
    7.
    发明授权
    Use of soluble pro(renin) receptor to treat metabolic disorders and related conditions 有权

    公开(公告)号：US11911442B2

    公开(公告)日：2024-02-27

    申请号：US18145730

    申请日：2022-12-22

    申请人： University of Utah Research Foundation

    发明人： Tianxin Yang

    IPC分类号： A61K38/00 ,  A61K38/17

    CPC分类号： A61K38/177

    摘要： Disclosed are methods of treating obesity or an obesity-related condition comprising administering an effective amount of soluble (pro)renin receptor (sPRR) to a subject that is obese or having an obesity-related condition. In some instances, obesity-related conditions can be, but are not limited to, steatosis, hyperglycemia, insulin resistance, chronic renal disease. Disclosed are methods of reducing body weight comprising administering an effective amount of sPRR to a subject in need thereof. Disclosed are methods of treating fatty liver in a subject comprising administering an effective amount of sPRR to a subject in need thereof. Disclosed are methods of treating a fluid and electrolyte disorder comprising administering an effective amount of sPRR to a subject diagnosed with a fluid and electrolyte disorder.

    COMBINATION THERAPY WITH NITRATED LIPIDS AND INHIBITORS OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
    9.
    发明申请
    COMBINATION THERAPY WITH NITRATED LIPIDS AND INHIBITORS OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM 有权
    与硝酸盐 - 阿托品酮系统的硝酸脂和抑制剂组合治疗

    公开(公告)号：US20140243380A1

    公开(公告)日：2014-08-28

    申请号：US14183468

    申请日：2014-02-18

    申请人： The University of Utah Research Foundation

    发明人： Tianxin Yang

    IPC分类号： A61K31/4178 ,  A61K45/06 ,  A61K31/201

    CPC分类号： A61K31/4178 ,  A61K31/20 ,  A61K31/201 ,  A61K31/401 ,  A61K31/41 ,  A61K45/06 ,  A61K2300/00

    摘要： The present technology provides compositions and methods for treating chronic kidney disease, end-stage renal disease, or diabetic nephropathy. The compositions comprise a nitrated lipid and an inhibitor of the renin-angiotensin-aldosterone system. The methods comprise administering a nitrated lipid in combination with an inhibitor of the renin-angiotensin-aldosterone system to a subject in need thereof, in an amount effective to treat diabetic nephropathy, chronic kidney disease, and/or end-stage renal disease. The use of a nitrated lipid with an inhibitor of the renin-angiotensin-aldosterone system exhibits a synergistic effect in treating chronic kidney disease and diabetic nephropathy.

    摘要翻译： 本技术提供治疗慢性肾脏疾病，终末期肾病或糖尿病肾病的组合物和方法。 组合物包含硝化脂质和肾素 - 血管紧张素 - 醛固酮系统的抑制剂。 所述方法包括以有效治疗糖尿病肾病，慢性肾脏疾病和/或终末期肾病的量将有效的肾素 - 血管紧张素 - 醛固酮系统的抑制剂的硝化脂质施用于有需要的受试者。 使用含有肾素 - 血管紧张素 - 醛固酮系统抑制剂的硝化脂质对治疗慢性肾脏疾病和糖尿病肾病具有协同作用。