公开(公告)号：US10780143B2

公开(公告)日：2020-09-22

申请号：US15501159

申请日：2015-07-31

申请人： University of Utah Research Foundation

发明人： Yumei Feng Earley ,  Tianxin Yang

IPC分类号： A61K38/10 ,  C07K7/08 ,  A61P9/12 ,  A61P17/02 ,  A61P31/00 ,  A61P13/12

摘要： Disclosed are methods of treating kidney disease, infectious or inflammatory diseases, acute kidney injury and hypertension by administering a (pro)renin receptor (PRR) antagonist. In some instances the PRR antagonist is a polypeptide. The PRR antagonist can be a polypeptide having at least 70% identity to the amino acid sequence set forth in SEQ ID NO:2. Also disclosed are methods of decreasing proteinuria and methods of promoting wound healing by administering a PRR antagonist.

公开(公告)号：US20180125922A1

公开(公告)日：2018-05-10

申请号：US15501159

申请日：2015-07-31

申请人： University of Utah Research Foundation

发明人： Yumei Feng Earley ,  Tianxin Yang

IPC分类号： A61K38/10 ,  C07K7/08 ,  A61P13/12 ,  A61P9/12 ,  A61P17/02 ,  A61P31/00

摘要： Disclosed are methods of treating kidney disease, infectious or inflammatory diseases, acute kidney injury and hypertension by administering a (pro)renin receptor (PRR) antagonist. In some instances the PRR antagonist is a polypeptide. The PRR antagonist can be a polypeptide having at least 70% identity to the amino acid sequence set forth in SEQ ID NO:2. Also disclosed are methods of decreasing proteinuria and methods of promoting wound healing by administering a PRR antagonist.