发明授权
US09192600B2 Combination therapy with nitrated lipids and inhibitors of the renin-angiotensin-aldosterone system
有权
用硝酸脂质和肾素 - 血管紧张素 - 醛固酮系统的抑制剂联合治疗
- 专利标题： Combination therapy with nitrated lipids and inhibitors of the renin-angiotensin-aldosterone system
- 专利标题（中）： 用硝酸脂质和肾素 - 血管紧张素 - 醛固酮系统的抑制剂联合治疗
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申请号： US14183468申请日： 2014-02-18
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公开(公告)号： US09192600B2公开(公告)日： 2015-11-24
- 发明人: Tianxin Yang
- 申请人： The University of Utah Research Foundation
- 申请人地址： US UT Salt Lake City
- 专利权人： The University of Utah Research Foundation
- 当前专利权人： The University of Utah Research Foundation
- 当前专利权人地址： US UT Salt Lake City
- 代理机构： Pepper Hamilton LLP
- 主分类号： A61K31/41
- IPC分类号： A61K31/41 ; A61K31/4178 ; A61K31/20 ; A61K31/201 ; A61K31/401 ; A61K45/06
摘要：
The present technology provides compositions and methods for treating chronic kidney disease, end-stage renal disease, or diabetic nephropathy. The compositions comprise a nitrated lipid and an inhibitor of the renin-angiotensin-aldosterone system. The methods comprise administering a nitrated lipid in combination with an inhibitor of the renin-angiotensin-aldosterone system to a subject in need thereof, in an amount effective to treat diabetic nephropathy, chronic kidney disease, and/or end-stage renal disease. The use of a nitrated lipid with an inhibitor of the renin-angiotensin-aldosterone system exhibits a synergistic effect in treating chronic kidney disease and diabetic nephropathy.
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