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公开(公告)号：US10471161B2
公开(公告)日：2019-11-12
申请号：US14773733
申请日：2014-03-08
Inventor： Zibo Li , Peter S. Conti , Lin Li , Zhanhong Wu , Shuanlong Liu , John E. Shively , David Horne
Abstract: A thio-selective radioactive labeling agent has the following general formula: *R-L-VS, wherein said *R is a radioisotope, L is a linking group, and VS is a vinylsulfone functional group.
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Patent Agency Ranking
公开(公告)号：US12043673B2
公开(公告)日：2024-07-23
申请号：US17503132
申请日：2021-10-15
Applicant: City of Hope
Inventor： John E. Shively , Lin Li , Maciej Kujawski , Piotr Swiderski
CPC classification number: C07K16/4283 , C07K16/283 , C07K16/2878 , C07K16/46 , C07K2317/24 , C07K2317/31 , C07K2317/52
Abstract: The compositions and methods provide herein include, inter alia, antibodies attached to single-stranded oligoribonucleotides. Two antibodies are capable of forming complexes in vivo through hybridization of the respective complementary oligoribonucleotides they are bound to. For example, a first antibody bound to a first oligoribonucleotide through a first chemical linker may be administered to a subject, bind to a cell surface antigen in vivo and subsequently form an antibody complex in vivo with a second antibody bound to a second oligoribonucleotide through a second chemical linker, through complementary base-pairing between the first and the second oligoribonucleotide. The compositions and methods provided herein are, inter alia, useful for diagnostic and therapeutic purposes, for example, the treatment of cancer or autoimmune disease.
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公开(公告)号：US10967070B2
公开(公告)日：2021-04-06
申请号：US15056777
申请日：2016-02-29
Applicant: City of Hope
Inventor： Andreas Herrmann , Hua Yu , Piotr Marek Swiderski , John Ernest Shively , Lin Li
IPC: A61K47/50 , C07K16/08 , C07K16/40 , C07K16/18 , A61K39/44 , A61K47/68 , A61K47/54 , A61K39/00 , A61K38/00 , C12N15/11
Abstract: Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone, wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non-cell penetrating protein. Also provided are compositions and kits comprising the cojugates.
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公开(公告)号：US20230001027A1
公开(公告)日：2023-01-05
申请号：US17764708
申请日：2020-09-30
Applicant: City of Hope
Inventor： John E. Shively , Michael R. Weist , Bradley J. Ahrens , Lin Li , Weidong Hu
IPC: A61K51/04
Abstract: Provided herein, inter alia, are methods and compositions for detection of vascular calcification.
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公开(公告)号：US20160317671A1
公开(公告)日：2016-11-03
申请号：US15056777
申请日：2016-02-29
Applicant: City of Hope
Inventor： Andreas Herrmann , Hua Yu , Piotr Marek Swiderski , John Ernest Shively , Lin Li
CPC classification number: A61K47/48092 , A61K38/00 , A61K39/44 , A61K47/549 , A61K47/6807 , A61K47/6843 , A61K2039/505 , A61K2039/507 , C07K16/084 , C07K16/18 , C07K16/40 , C07K2317/73 , C07K2317/76 , C07K2319/10 , C12N15/11 , C12N2310/315 , C12N2310/3513
Abstract: Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone, wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non-cell penetrating protein. Also provided are compositions and kits comprising the cojugates.
Abstract translation: 本文提供细胞穿透共轭物。 缀合物包括与硫代磷酸酯核酸或硫代磷酸酯聚合物骨架连接的非细胞穿透蛋白，其中硫代磷酸酯核酸或硫代磷酸酯聚合物主链增强非细胞穿透性蛋白质的细胞内递送。 还提供了包含缀合物的组合物和试剂盒。
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公开(公告)号：US20220119552A1
公开(公告)日：2022-04-21
申请号：US17503132
申请日：2021-10-15
Applicant: City of Hope
Inventor： John E. Shively , Lin Li , Maciej Kujawski , Piotr Swiderski
Abstract: The compositions and methods provide herein include, inter alia, antibodies attached to single-stranded oligoribonucleotides. Two antibodies are capable of forming complexes in vivo through hybridization of the respective complementary oligoribonucleotides they are bound to. For example, a first antibody bound to a first oligoribonucleotide through a first chemical linker may be administered to a subject, bind to a cell surface antigen in vivo and subsequently form an antibody complex in vivo with a second antibody bound to a second oligoribonucleotide through a second chemical linker, through complementary base-pairing between the first and the second oligoribonucleotide. The compositions and methods provided herein are, inter alia, useful for diagnostic and therapeutic purposes, for example, the treatment of cancer or autoimmune disease.
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