公开(公告)号：US20160317671A1

公开(公告)日：2016-11-03

申请号：US15056777

申请日：2016-02-29

Applicant: City of Hope

Inventor： Andreas Herrmann ,  Hua Yu ,  Piotr Marek Swiderski ,  John Ernest Shively ,  Lin Li

IPC: A61K47/48 ,  C07K16/08 ,  C07K16/40 ,  A61K39/44 ,  C07K16/18

CPC classification number: A61K47/48092 ,  A61K38/00 ,  A61K39/44 ,  A61K47/549 ,  A61K47/6807 ,  A61K47/6843 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/084 ,  C07K16/18 ,  C07K16/40 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/10 ,  C12N15/11 ,  C12N2310/315 ,  C12N2310/3513

Abstract: Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone, wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non-cell penetrating protein. Also provided are compositions and kits comprising the cojugates.

Abstract translation: 本文提供细胞穿透共轭物。 缀合物包括与硫代磷酸酯核酸或硫代磷酸酯聚合物骨架连接的非细胞穿透蛋白，其中硫代磷酸酯核酸或硫代磷酸酯聚合物主链增强非细胞穿透性蛋白质的细胞内递送。 还提供了包含缀合物的组合物和试剂盒。

公开(公告)号：US10967070B2

公开(公告)日：2021-04-06

申请号：US15056777

申请日：2016-02-29

Applicant: City of Hope

Inventor： Andreas Herrmann ,  Hua Yu ,  Piotr Marek Swiderski ,  John Ernest Shively ,  Lin Li

IPC: A61K47/50 ,  C07K16/08 ,  C07K16/40 ,  C07K16/18 ,  A61K39/44 ,  A61K47/68 ,  A61K47/54 ,  A61K39/00 ,  A61K38/00 ,  C12N15/11

Abstract: Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein attached to a phosphorothioate nucleic acid or phosphorothioate polymer backbone, wherein the phosphorothioate nucleic acid or phosphorothioate polymer backbone enhances intracellular delivery of the non-cell penetrating protein. Also provided are compositions and kits comprising the cojugates.

公开(公告)号：US20200181264A1

公开(公告)日：2020-06-11

申请号：US16637705

申请日：2018-08-10

Applicant: CITY OF HOPE ,  APTERNA LIMITED

Inventor： John J. Rossi ,  Sarah Yoon ,  Piotr Marek Swiderski ,  Nagy Habib ,  John Ernest Shively

IPC: C07K16/28 ,  C07K16/30 ,  C12N15/115 ,  A61P35/00

Abstract: Provided herein relates to antigen-binding molecules, in particular bispecific antigen-binding molecules that bind to a cancer cell antigen and an immune cell surface molecule.