公开(公告)号：US20190160165A1

公开(公告)日：2019-05-30

申请号：US16180519

申请日：2018-11-05

Applicant: University of Massachusetts

Inventor： Shan Lu ,  Shixia Wang

IPC: A61K39/21 ,  C07K14/005 ,  A61K39/12 ,  A61K45/06 ,  C12N7/00

Abstract: Polyvalent, primary isolate nucleic acid compositions for inducing an immune response against HIV are disclosed. The compositions and methods described herein are for the use of a nucleic acid composition that encodes one or more different HIV envelope glycoproteins. The synthetic, codon-optimized DNAs encoding one or more HIV proteins are a combination of different nucleic acids, such as DNA plasmids, generated from primary isolate DNA of different HIV major group genetic clades and/or different proteins. HIV polypeptide compositions for inducing an immune response against HIV are also disclosed. Methods for using the polypeptide compositions before, at the same time as, and/or after administration of the DNA compositions are provided.

公开(公告)号：US11690906B2

公开(公告)日：2023-07-04

申请号：US17096579

申请日：2020-11-12

Applicant: University of Massachusetts

Inventor： Shan Lu ,  Shixia Wang

IPC: A61K39/21 ,  A61K39/12 ,  A61K45/06 ,  C07K14/005 ,  C12N7/00 ,  A61K39/00

CPC classification number: A61K39/21 ,  A61K39/12 ,  A61K45/06 ,  C07K14/005 ,  C12N7/00 ,  H05K999/99 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/575 ,  A61K2039/70 ,  C12N2740/16134

Abstract: Polyvalent, primary isolate nucleic acid compositions for inducing an immune response against HIV are disclosed. The compositions and methods described herein are for the use of a nucleic acid composition that encodes one or more different HIV envelope glycoproteins. The synthetic, codon-optimized DNAs encoding one or more HIV proteins are a combination of different nucleic acids, such as DNA plasmids, generated from primary isolate DNA of different HIV major group genetic clades and/or different proteins. HIV polypeptide compositions for inducing an immune response against HIV are also disclosed. Methods for using the polypeptide compositions before, at the same time as, and/or after administration of the DNA compositions are provided.

公开(公告)号：US20160015802A1

公开(公告)日：2016-01-21

申请号：US14776682

申请日：2014-03-13

Applicant: University of Massachusetts

Inventor： Shan Lu ,  Shixia Wang

IPC: A61K39/21 ,  C12N7/00 ,  A61K45/06 ,  C07K14/005

CPC classification number: A61K39/21 ,  A61K39/12 ,  A61K45/06 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/575 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2740/16134

Abstract: Polyvalent, primary isolate nucleic acid compositions for inducing an immune response against HIV are disclosed. The compositions and methods described herein are for the use of a nucleic acid composition that encodes one or more different HIV envelope glycoproteins. The synthetic, codon-optimized DNAs encoding one or more HIV proteins are a combination of different nucleic acids, such as DNA plasmids, generated from primary isolate DNA of different HIV major group genetic clades and/or different proteins. HIV polypeptide compositions for inducing an immune response against HIV are also disclosed. Methods for using the polypeptide compositions before, at the same time as, and/or after administration of the DNA compositions are provided.

Abstract translation: 公开了用于诱导针对HIV的免疫应答的多价的初级分离核酸组合物。 本文描述的组合物和方法是用于编码一种或多种不同HIV包膜糖蛋白的核酸组合物。 编码一种或多种HIV蛋白质的合成的密码子优化的DNA是由不同的HIV主要群体遗传进化枝和/或不同蛋白质的初级分离物DNA产生的不同核酸，例如DNA质粒的组合。 还公开了用于诱导针对HIV的免疫应答的HIV多肽组合物。 提供了在给予DNA组合物之前，同时和/或之后使用多肽组合物的方法。

公开(公告)号：US20170258892A1

公开(公告)日：2017-09-14

申请号：US15600092

申请日：2017-05-19

Applicant: University of Massachusetts

Inventor： Shan Lu ,  Shixia Wang

IPC: A61K39/21 ,  A61K39/12 ,  A61K45/06 ,  C07K14/005 ,  C12N7/00 ,  A61K39/00

CPC classification number: A61K39/21 ,  A61K39/12 ,  A61K45/06 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/575 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2740/16134

Abstract: Polyvalent, primary isolate nucleic acid compositions for inducing an immune response against HIV are disclosed. The compositions and methods described herein are for the use of a nucleic acid composition that encodes one or more different HIV envelope glycoproteins. The synthetic, codon-optimized DNAs encoding one or more HIV proteins are a combination of different nucleic acids, such as DNA plasmids, generated from primary isolate DNA of different HIV major group genetic clades and/or different proteins. HIV polypeptide compositions for inducing an immune response against HIV are also disclosed. Methods for using the polypeptide compositions before, at the same time as, and/or after administration of the DNA compositions are provided.

公开(公告)号：US20210138062A1

公开(公告)日：2021-05-13

申请号：US17096579

申请日：2020-11-12

Applicant: University of Massachusetts

Inventor： Shan Lu ,  Shixia Wang

IPC: A61K39/21 ,  A61K39/12 ,  A61K45/06 ,  C07K14/005 ,  C12N7/00

Abstract: Polyvalent, primary isolate nucleic acid compositions for inducing an immune response against HIV are disclosed. The compositions and methods described herein are for the use of a nucleic acid composition that encodes one or more different HIV envelope glycoproteins. The synthetic, codon-optimized DNAs encoding one or more HIV proteins are a combination of different nucleic acids, such as DNA plasmids, generated from primary isolate DNA of different HIV major group genetic clades and/or different proteins. HIV polypeptide compositions for inducing an immune response against HIV are also disclosed. Methods for using the polypeptide compositions before, at the same time as, and/or after administration of the DNA compositions are provided.

公开(公告)号：US10124060B2

公开(公告)日：2018-11-13

申请号：US15600092

申请日：2017-05-19

Applicant: University of Massachusetts

Inventor： Shan Lu ,  Shixia Wang

IPC: A61K39/21 ,  A61K39/12 ,  A61K45/06 ,  C07K14/005 ,  C12N7/00 ,  A61K39/00

Abstract: Polyvalent, primary isolate nucleic acid compositions for inducing an immune response against HIV are disclosed. The compositions and methods described herein are for the use of a nucleic acid composition that encodes one or more different HIV envelope glycoproteins. The synthetic, codon-optimized DNAs encoding one or more HIV proteins are a combination of different nucleic acids, such as DNA plasmids, generated from primary isolate DNA of different HIV major group genetic clades and/or different proteins. HIV polypeptide compositions for inducing an immune response against HIV are also disclosed. Methods for using the polypeptide compositions before, at the same time as, and/or after administration of the DNA compositions are provided.

公开(公告)号：US09675687B2

公开(公告)日：2017-06-13

申请号：US14776682

申请日：2014-03-13

Applicant: University of Massachusetts

Inventor： Shan Lu ,  Shixia Wang

IPC: A61K39/21 ,  A61K39/12 ,  A61K45/06 ,  C07K14/005 ,  C12N7/00 ,  A61K39/00

CPC classification number: A61K39/21 ,  A61K39/12 ,  A61K45/06 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/575 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2740/16134

Abstract: Polyvalent, primary isolate nucleic acid compositions for inducing an immune response against HIV are disclosed. The compositions and methods described herein are for the use of a nucleic acid composition that encodes one or more different HIV envelope glycoproteins. The synthetic, codon-optimized DNAs encoding one or more HIV proteins are a combination of different nucleic acids, such as DNA plasmids, generated from primary isolate DNA of different HIV major group genetic clades and/or different proteins. HIV polypeptide compositions for inducing an immune response against HIV are also disclosed. Methods for using the polypeptide compositions before, at the same time as, and/or after administration of the DNA compositions are provided.