知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

13 条记录 (耗时 0.016 秒)

    17-azasteroids
    9.
    发明授权
    17-azasteroids 失效
    17-AZASTEROIDS

    公开(公告)号：US3634419A

    公开(公告)日：1972-01-11

    申请号：US3634419D

    申请日：1969-07-28

    申请人： UPJOHN CO

    发明人： NELSON NORMAN A ,  JACKSON ROBERT W

    IPC分类号： C07D209/58 ,  C07D498/08 ,  C07D27/30

    CPC分类号： C07D209/58

    摘要： THIS INVENTION RELATES TO NOVEL 17-AZASTEROIDS, TO PROESSES FOR THEIR PREPARATION AND MORE PARTICULARLY TO COMPOUNDS EMBRACED BY THE FOLLOWING FORMULA:

    1,2-(-X-CH2-CH(-)-N(-Z)-CH2-CH2-CH(-)-),6-(O=),8A-(CH3-)

    1,2,6,7,8,8A-HEXAHYDRONAPHTHALENE

    WHEREIN Z IS HYDROGEN, ALKYL,-SO2R, IN WHICH R IS ALKYL OR ARYL, -COR1, IN WHICH R1 IS ALKYL, AND -COOR1 IN WHICH R1 IS ALKYL, AND X IS CARBONYL (>C=O), A-HYDROXYMETHYLENE

    -C(-H)(--OH)- OR -C(--H)(-OH)-

    AND THE PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS OF THOSE COMPOUNDS OF FORMULA V, ABOVE, WHEREIN Z IS HYDROGEN OR ALKYL. THE COMPOUNDS OF THE ABOVE FORMULA V ARE ANTI-INFLAMMATORY AGENTS; CENTRAL NERVOUS SYSTEM STIMULANTS, AND ANTIFUNGAL AND ANTIMICROBIAL AGENTS.