公开(公告)号：US20210340519A1

公开(公告)日：2021-11-04

申请号：US17336889

申请日：2021-06-02

申请人： UNIVERSITY OF WASHINGTON ,  UNIVERSITY OF UTAH

发明人： Neil KING ,  Wesley SUNDQUIST ,  Joerg VOTTELER ,  Yang HSIA ,  David BAKER ,  Jacob BALE ,  Marc LAJOIE ,  Gabriel BUTTERFIELD ,  Elizabeth GRAY ,  Daniel STETSON

IPC分类号： C12N9/88 ,  C07K14/00 ,  C07K14/435

摘要： The application discloses multimeric assemblies including multiple oligomeric substructures, where each oligomeric substructure includes multiple proteins that self-interact around at least one axis of rotational symmetry, where each protein includes one or more polypeptide-polypeptide interface (“O interface”); and one or more polypeptide domain that is capable of effecting membrane scission and release of an enveloped multimeric assembly from a cell by recruiting the ESCRT machinery to the site of budding by binding to one or more proteins in the eukaryotic ESCRT complex (“L domain”); and where the multimeric assembly includes one or more subunits comprising one or more polypeptide domain that is capable of interacting with a lipid bilayer (“M domain”), as well as membrane-enveloped versions of the multimeric assemblies.

公开(公告)号：US20180030429A1

公开(公告)日：2018-02-01

申请号：US15541201

申请日：2016-02-29

申请人： UNIVERSITY OF WASHINGTON ,  UNIVERSITY OF UTAH

发明人： Neil KING ,  Wesley SUNDQUIST ,  Joerg VOTTELER ,  Yang HSIA ,  David BAKER ,  Jacob BALE ,  Marc LAJOIE ,  Gabriel BUTTERFIELD ,  Elizabeth GRAY ,  Daniel STETSON

IPC分类号： C12N9/88

CPC分类号： C12N9/88 ,  C07K14/00 ,  C07K14/435 ,  C07K2319/03 ,  C07K2319/06 ,  C07K2319/735 ,  C12Y401/02014

摘要： The application discloses multimeric assemblies including multiple oligomeric substructures, where each oligomeric substructure includes multiple proteins that self-interact around at least one axis of rotational symmetry, where each protein includes one or more polypeptide-polypeptide interface (“O interface”); and one or more polypeptide domain that is capable of effecting membrane scission and release of an enveloped multimeric assembly from a cell by recruiting the ESCRT machinery to the site of budding by binding to one or more proteins in the eukaryotic ESCRT complex (“L domain”); and where the multimeric assembly includes one or more subunits comprising one or more polypeptide domain that is capable of interacting with a lipid bilayer (“M domain”), as well as membrane-enveloped versions of the multimeric assemblies.

公开(公告)号：US20200224186A1

公开(公告)日：2020-07-16

申请号：US16676253

申请日：2019-11-06

申请人： UNIVERSITY OF WASHINGTON ,  UNIVERSITY OF UTAH

发明人： Neil KING ,  Wesley SUNDQUIST ,  Joerg VOTTELER ,  Yang HSIA ,  David BAKER ,  Jacob BALE ,  Marc LAJOIE ,  Gabriel BUTTERFIELD ,  Elizabeth GRAY ,  Daniel STETSON

IPC分类号： C12N9/88 ,  C07K14/00 ,  C07K14/435

摘要： The application discloses multimeric assemblies including multiple oligomeric substructures, where each oligomeric substructure includes multiple proteins that self-interact around at least one axis of rotational symmetry, where each protein includes one or more polypeptide-polypeptide interface (“O interface”); and one or more polypeptide domain that is capable of effecting membrane scission and release of an enveloped multimeric assembly from a cell by recruiting the ESCRT machinery to the site of budding by binding to one or more proteins in the eukaryotic ESCRT complex (“L domain”); and where the multimeric assembly includes one or more subunits comprising one or more polypeptide domain that is capable of interacting with a lipid bilayer (“M domain”), as well as membrane-enveloped versions of the multimeric assemblies.

公开(公告)号：US20190341124A1

公开(公告)日：2019-11-07

申请号：US16271571

申请日：2019-02-08

申请人： University of Washington through its center for commercialization

发明人： David BAKER ,  Neil KING ,  Jacob BALE ,  William SHEFFLER

IPC分类号： G16B20/00 ,  G16B15/00 ,  G16B5/00 ,  C07K14/195 ,  G01N33/68 ,  C07K14/00

摘要： Synthetic nanostructures, proteins that are useful, for example, in making synthetic nanostructures, and methods for designing such synthetic nanostructures are disclosed herein.

公开(公告)号：US20150356240A1

公开(公告)日：2015-12-10

申请号：US14759308

申请日：2014-02-07

申请人： UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

发明人： David BAKER ,  Neil KING ,  Jacob BALE ,  William SHEFFLER

IPC分类号： G06F19/18 ,  G06F19/12 ,  G06F19/16 ,  C07K14/00 ,  G01N33/68

CPC分类号： G06F19/18 ,  B82Y5/00 ,  C07K14/00 ,  C07K14/195 ,  C07K2319/735 ,  G01N33/6845 ,  G01N2570/00 ,  G06F19/12 ,  G06F19/16

摘要： Synthetic nanostructures, proteins that are useful, for example, in making synthetic nanostructures, and methods for designing such synthetic nanostructures are disclosed herein.

摘要翻译： 本文公开了合成纳米结构，可用于制备合成纳米结构的蛋白质，以及用于设计这种合成纳米结构的方法。