专利检索 ap:("UNIVERSITY OF WASHINGTON") AND inv:"Eric T. LARSON" 第 1 页

1.

发明申请
COMPOSITIONS AND METHODS FOR TREATING TOXOPLASMOSIS, CRYPTOSPORIDIOSIS AND OTHER APICOMPLEXAN PROTOZOAN RELATED DISEASES 审中-公开

公开(公告)号：US20180273537A1

公开(公告)日：2018-09-27

申请号：US15544606

申请日：2016-01-26

申请人： UNIVERSITY OF WASHINGTON

发明人： Wilhelmus G.J HOL , Eric T. LARSON , Dustin James MALY , Wesley C. VAN VOORHIS , Ethan MERRITT , Kayode K. OJO

IPC分类号： C07D487/04 , A61P33/02

CPC分类号： A61K31/519 , A61K31/4985 , A61P33/02 , A61P35/00 , C07D487/04 , Y02A50/411 , Y02A50/488

摘要： The present disclosure is directed to compositions and methods for inhibiting either Toxoplasma gondii (T. gondii) calcium dependent protein kinases (TgCDPKs) or Cryptosporidium parvum (C. parvum) and Cryptosporidium hominus (C. hominus) calcium dependent protein kinases (CpCDPKs) using pyrazolopyrimidine and/or imidazo[1,5-a]pyrazine inhibitors, of the Formula (I), wherein the variables X, Y, Z, R1, and R3 are defined herein.