公开(公告)号：US20240309435A1

公开(公告)日：2024-09-19

申请号：US18595259

申请日：2024-03-04

申请人： UNIVERSITY OF SOUTH FLORIDA

发明人： Hana Totary-Jain

IPC分类号： C12Q1/6841 ,  C12Q1/6809 ,  C12Q1/6876 ,  C12Q1/70

CPC分类号： C12Q1/6841 ,  C12Q1/6809 ,  C12Q1/6876 ,  C12Q1/70

摘要： The present disclosure describes methods of detecting the presence and/or the level of Alu RNA in a subject sample, using a novel competitive reverse-transcription PCR and in situ hybridization methods and reagents.

公开(公告)号：US11844809B2

公开(公告)日：2023-12-19

申请号：US17834611

申请日：2022-06-07

申请人： University of South Florida

发明人： Hana Totary-Jain

IPC分类号： C07H21/02 ,  A61K31/7105 ,  A61P37/04 ,  A61P31/04 ,  A61P31/12 ,  A61K39/12 ,  A61P31/10 ,  C12N15/11 ,  A61K39/00

CPC分类号： A61K31/7105 ,  A61K39/12 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P37/04 ,  C12N15/111 ,  A61K2039/53 ,  C12N2320/30

摘要： Disclosed herein are compositions and methods for inducing, promoting, or enhancing an immune response in a subject. For example, the disclosed compositions and methods can be used prophylactically to prevent viral/microbial infections or therapeutically to treat acute infections. In some embodiments, the disclosed method involves administering to the subject a composition comprising in vitro transcribed (IVT) RNA comprising short interspersed nuclear elements (SINEs), such as Alu repeats. In some embodiments, the disclosed compositions and methods can be used to induce, promote, or enhance any immune response in a subject, including an anti-viral, anti-microbial, anti-fungal, or anti-parasite response. In some embodiments, the disclosed compositions can be administered to any mucosal barrier, such as lungs or intestines, e.g. to enhance an innate immune response against a virus or pathogen.

公开(公告)号：US11357789B1

公开(公告)日：2022-06-14

申请号：US16408518

申请日：2019-05-10

申请人： University of South Florida

发明人： Hana Totary-Jain

IPC分类号： C07H21/02 ,  C07H21/04 ,  A61K31/7105 ,  A61P37/04 ,  A61P31/04 ,  A61P31/12 ,  A61K39/12 ,  A61P31/10 ,  C12N15/11 ,  A61K39/00

摘要： Disclosed herein are compositions and methods for inducing, promoting, or enhancing an immune response in a subject. For example, the disclosed compositions and methods can be used prophylactically to prevent viral/microbial infections or therapeutically to treat acute infections. In some embodiments, the disclosed method involves administering to the subject a composition comprising in vitro transcribed (IVT) RNA comprising short interspersed nuclear elements (SINEs), such as Alu repeats. In some embodiments, the disclosed compositions and methods can be used to induce, promote, or enhance any immune response in a subject, including an anti-viral, anti-microbial, anti-fungal, or anti-parasite response. In some embodiments, the disclosed compositions can be administered to any mucosal barrier, such as lungs or intestines, e.g. to enhance an innate immune response against a virus or pathogen.

公开(公告)号：US11155880B1

公开(公告)日：2021-10-26

申请号：US16594930

申请日：2019-10-07

申请人： University of South Florida

发明人： Hana Totary-Jain ,  Ezinne Francess Mong

IPC分类号： C12Q1/6886 ,  C12Q1/6883 ,  A61K48/00 ,  C12N15/11

摘要： Provided herein are methods of measuring C19MC miRNA amount and/or expression in a post-natal cell and/or tissue. Provided herein are methods of measuring CpG methylation of the upstream C19MC miRNA promoter region in a post-natal cell and/or tissue. Also provided herein are methods of treating a cell, population thereof, and/or a subject in need thereof by administering a C19MC miRNA inhibitor or CRISPR to suppress the expression of specific miRNA within the C19MC or the entire C19MC cluster, population thereof, and/or the subject in need thereof.

公开(公告)号：US11857598B2

公开(公告)日：2024-01-02

申请号：US17400984

申请日：2021-08-12

申请人： University of South Florida

发明人： Hana Totary-Jain

IPC分类号： C07H21/04 ,  A61K38/17 ,  A61K31/7115 ,  A61K31/7088

CPC分类号： A61K38/1709 ,  A61K31/7088 ,  A61K31/7115 ,  C12Y207/07048 ,  C12N2310/113 ,  C12N2710/10343 ,  C12N2310/141 ,  C12N2330/10

摘要： Described herein are cell-selective mRNA constructs that can contain a RNA of interest and one or more miRNA targets. The cell-selective mRNA constructs described herein can be used to express an RNA of interest to a cell in a cell-selective manner.

公开(公告)号：US20210369810A1

公开(公告)日：2021-12-02

申请号：US17400984

申请日：2021-08-12

申请人： University of South Florida

发明人： Hana Totary-Jain

IPC分类号： A61K38/17 ,  A61K31/7088 ,  A61K31/7115

摘要： Described herein are cell-selective mRNA constructs that can contain a RNA of interest and one or more miRNA targets. The cell-selective mRNA constructs described herein can be used to express an RNA of interest to a cell in a cell-selective manner.

公开(公告)号：US12012637B2

公开(公告)日：2024-06-18

申请号：US17513279

申请日：2021-10-28

申请人： University of South Florida

发明人： Hana Totary-Jain

IPC分类号： C12Q1/6886

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  C12Q2600/178

摘要： The present disclosure relates to methods for detecting and treating propranolol sensitive tumors.

公开(公告)号：US20240082290A1

公开(公告)日：2024-03-14

申请号：US18512489

申请日：2023-11-17

申请人： University of South Florida

发明人： Hana Totary-Jain

IPC分类号： A61K31/7105 ,  A61K39/12 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P37/04 ,  C12N15/11

CPC分类号： A61K31/7105 ,  A61K39/12 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P37/04 ,  C12N15/111 ,  A61K2039/53

摘要： Disclosed herein are compositions and methods for inducing, promoting, or enhancing an immune response in a subject. For example, the disclosed compositions and methods can be used prophylactically to prevent viral/microbial infections or therapeutically to treat acute infections. In some embodiments, the disclosed method involves administering to the subject a composition comprising in vitro transcribed (IVT) RNA comprising short interspersed nuclear elements (SINEs), such as Alu repeats. In some embodiments, the disclosed compositions and methods can be used to induce, promote, or enhance any immune response in a subject, including an anti-viral, anti-microbial, anti-fungal, or anti-parasite response. In some embodiments, the disclosed compositions can be administered to any mucosal barrier, such as lungs or intestines, e.g. to enhance an innate immune response against a virus or pathogen.

公开(公告)号：US20220296630A1

公开(公告)日：2022-09-22

申请号：US17834611

申请日：2022-06-07

申请人： University of South Florida

发明人： Hana Totary-Jain

IPC分类号： A61K31/7105 ,  A61P37/04 ,  A61P31/04 ,  A61P31/12 ,  A61K39/12 ,  A61P31/10 ,  C12N15/11

摘要： Disclosed herein are compositions and methods for inducing, promoting, or enhancing an immune response in a subject. For example, the disclosed compositions and methods can be used prophylactically to prevent viral/microbial infections or therapeutically to treat acute infections. In some embodiments, the disclosed method involves administering to the subject a composition comprising in vitro transcribed (IVT) RNA comprising short interspersed nuclear elements (SINEs), such as Alu repeats. In some embodiments, the disclosed compositions and methods can be used to induce, promote, or enhance any immune response in a subject, including an anti-viral, anti-microbial, anti-fungal, or anti-parasite response. In some embodiments, the disclosed compositions can be administered to any mucosal barrier, such as lungs or intestines, e.g. to enhance an innate immune response against a virus or pathogen.

公开(公告)号：US20190133974A1

公开(公告)日：2019-05-09

申请号：US16183025

申请日：2018-11-07

申请人： University of South Florida

发明人： Hana Totary-Jain

IPC分类号： A61K31/138 ,  C12Q1/6886

摘要： The present disclosure relates to methods for detecting and treating propranolol sensitive tumors.