公开(公告)号：US20220306983A1

公开(公告)日：2022-09-29

申请号：US17431144

申请日：2020-09-11

申请人： UNIVERSITY OF SHANGHAI FOR SCIENCE AND TECHNOLOGY

发明人： LIANZHONG AI ,  ZHIQIANG XIONG ,  YONGJUN XIA ,  GUANGQIANG WANG ,  HUI ZHANG ,  FENGXI LAI ,  XIN SONG

IPC分类号： C12N1/20 ,  A61K35/747 ,  A61P9/10

摘要： A Lactobacillus plantarum strain AR113 with protection effect on apoplexy. The Lactobacillus plantarum strain AR113 deposited in China General Microbiological Culture Collection Center (CGMCC) under CGMCC Accession No. 13909 on Mar. 22, 2017. The Lactobacillus plantarum AR113 strain can increase the antioxidant enzyme activity of brain tissue, reduce the level of oxidation products, activate the Nrf-ARE signal pathway, and regulate the relative expression of antioxidant factors Nrf2, NQO-1, and HO-1. Additionally, it can down-regulate the mRNA expression of pro-apoptotic factors Cyt-C, Caspase-3 and Bax, and up-regulate the relative expression of anti-apoptotic factor Bcl-2, thereby improving brain cell damage caused by cerebral ischemia and reperfusion.

公开(公告)号：US20220305069A1

公开(公告)日：2022-09-29

申请号：US17431145

申请日：2020-09-11

申请人： UNIVERSITY OF SHANGHAI FOR SCIENCE AND TECHNOLOGY

发明人： LIANZHONG AI ,  YONGJUN XIA ,  PENG MENG ,  HUI ZHANG ,  GUANGQIANG WANG ,  ZHIQIANG XIONG ,  XIN SONG

IPC分类号： A61K36/07 ,  A23L33/21 ,  A23L31/00 ,  B01D11/02 ,  A61P3/06

摘要： A preparation method of Antrodia cinnamomea water-insoluble dietary fiber. After ethanol and water extraction, Antrodia cinnamomea wastes are dried and superfine-comminuted to obtain Antrodia cinnamomea waste powder. The waste powder treated with NaOH solution containing NaBH4 is extracted it twice to obtain two extracts. The two extracts are combined and an appropriate amount of glacial acetic acid are added for neutralization. The extracts are centrifugalized and precipitate is collected. After washing the precipitate with ultrapure water, the precipitate is dissolved with LiCl-DMSO. The precipitate that is insoluble in the LiCl-DMSO solution is dialyzed and freeze-dried to obtain the water-insoluble dietary fiber component ACA-IDK of Antrodia cinnamomea. The LiCl-DMSO solution is subjected to ethanol/DMSO fractional precipitation, and then the precipitate is collected and dialyzed. The water-insoluble dietary fiber component ACA-DK of Antrodia cinnamomea is obtained after freeze-drying.