公开(公告)号：US20220144783A1

公开(公告)日：2022-05-12

申请号：US17435939

申请日：2020-03-11

申请人： UNIVERSITY OF DURHAM

发明人： Andrew Whiting ,  David Chisholm ,  Iain Greig ,  Thabat Khatib ,  Peter McCaffery

IPC分类号： C07D241/38 ,  C07D213/79 ,  C07D233/96 ,  C07C63/74 ,  C07D401/06 ,  C07D213/80 ,  C07D241/24 ,  C07C65/26 ,  A61P25/28 ,  G01N33/50 ,  G01N33/68 ,  C12Q1/48

摘要： The present invention relates to compounds of formula I: in which A1-A7 and R1 to R5 are defined herein, for use in the treatment of a condition or disease which is alleviated by the activation of retinoic acid receptors (RAR). The invention also relates to pharmaceutical compounds comprising such compounds, and related methods of treatment. In an aspect, the invention relates to a method of screening compounds for therapeutic potential in the treatment of a condition or disease which is alleviated by the activation of retinoic acid receptors (RAR). Aspects of the invention relate to novel compounds of formula I in which at least one of A1 to A3 is or at least one of A4 is CR12 or A5 is CR13 in which R12/R13 is halogen.

公开(公告)号：US20190112272A1

公开(公告)日：2019-04-18

申请号：US16092106

申请日：2017-04-06

申请人： High Force Research Limited ,  University of Durham ,  The University Court of The University of Aberdeen

发明人： Andrew Whiting ,  Roy Valentine ,  David Chisholm ,  Peter McCaffery ,  Iain Greig ,  Thabat Khatib

IPC分类号： C07D215/06 ,  C07D209/08 ,  C07D417/04 ,  C07C63/66 ,  A61P25/16 ,  A61P25/08 ,  A61P25/28

摘要： There are described novel compounds of formula I: in which R1, R2, R3, R4, R5, X1 and X2 are each as herein defined, for use in the treatment or alleviation of an RAR miated condition: and methods related thereto.