- 专利标题： SYNTHETIC RETINOIDS FOR USE IN RAR ACTIVATION
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申请号： US17435939申请日： 2020-03-11
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公开(公告)号： US20220144783A1公开(公告)日： 2022-05-12
- 发明人: Andrew Whiting , David Chisholm , Iain Greig , Thabat Khatib , Peter McCaffery
- 申请人： UNIVERSITY OF DURHAM
- 申请人地址： GB Durham
- 专利权人： UNIVERSITY OF DURHAM
- 当前专利权人： UNIVERSITY OF DURHAM
- 当前专利权人地址： GB Durham
- 优先权： GB1903242.4 20190311
- 国际申请： PCT/GB2020/050607 WO 20200311
- 主分类号： C07D241/38
- IPC分类号： C07D241/38 ; C07D213/79 ; C07D233/96 ; C07C63/74 ; C07D401/06 ; C07D213/80 ; C07D241/24 ; C07C65/26 ; A61P25/28 ; G01N33/50 ; G01N33/68 ; C12Q1/48
摘要：
The present invention relates to compounds of formula I: in which A1-A7 and R1 to R5 are defined herein, for use in the treatment of a condition or disease which is alleviated by the activation of retinoic acid receptors (RAR). The invention also relates to pharmaceutical compounds comprising such compounds, and related methods of treatment. In an aspect, the invention relates to a method of screening compounds for therapeutic potential in the treatment of a condition or disease which is alleviated by the activation of retinoic acid receptors (RAR). Aspects of the invention relate to novel compounds of formula I in which at least one of A1 to A3 is or at least one of A4 is CR12 or A5 is CR13 in which R12/R13 is halogen.
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