公开(公告)号：US20160347841A1

公开(公告)日：2016-12-01

申请号：US14898037

申请日：2014-06-17

Applicant: UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO

Inventor： Lourival Domingos POSSANI POSTAY ,  María Martha PEDRAZA ESCALONA ,  Gerardo Pavel ESPINO SOLIS ,  Alejandro OLVERA RODRÍGUEZ ,  Héctor Miguel CARDOSO TORRES

IPC: C07K16/28 ,  A61K39/145 ,  C12N7/00 ,  A61K47/48

CPC classification number: C07K16/2851 ,  A61K39/145 ,  A61K47/6833 ,  A61K47/6849 ,  A61K2039/505 ,  A61K2039/552 ,  C07K14/005 ,  C12N7/00 ,  C12N2760/16122 ,  C12N2760/16131 ,  C12N2760/16134 ,  A61K2039/507

Abstract: The invention relates to the production and the characterisation of new murine monoclonal antibodies that recognize the domain CTD-2 (SEQ ID NO: 1) of the cell receptor DEC-205 of dendritic cells in chickens (Gallus gallus), pigs, (Sus scrofa) and humans (Homo sapiens). The invention also relates to the capacity of the new antibodies to direct and modulate the immune response at different levels in chickens (Gallus gallus) and pigs (Sus scrofa), as well as recognising the receptor DEC-205 in dentritic cells and cell lines in humans, In addition, the invention is used to quickly produce a specific humoral immune response against Hemaglutinina H5 of the H5N2-type avian flu virus.

Abstract translation: 本发明涉及识别鸡（Gallus gallus），猪（Sus scrofa）中树突状细胞的细胞受体DEC-205的结构域CTD-2（SEQ ID NO：1）的新型鼠单克隆抗体的产生和表征 ）和人（智人）。 本发明还涉及新抗体在鸡（Gallus gallus）和猪（Sus scrofa）中引导和调节不同水平的免疫应答的能力，以及在牙髓细胞和细胞系中识别受体DEC-205 人类，此外，本发明用于快速产生针对H5N2型禽流感病毒的Hemaglutinina H5的特异性体液免疫应答。