Invention Application
US20160347841A1 NEW MONOCLONAL ANTIBODIES AGAINST THE RECEPTOR DEC-205 OF CHICKEN DENTRITIC CELLS
有权
新的单克隆抗体对鸡胸腺细胞的受体DEC-205
- Patent Title: NEW MONOCLONAL ANTIBODIES AGAINST THE RECEPTOR DEC-205 OF CHICKEN DENTRITIC CELLS
- Patent Title (中): 新的单克隆抗体对鸡胸腺细胞的受体DEC-205
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Application No.: US14898037Application Date: 2014-06-17
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Publication No.: US20160347841A1Publication Date: 2016-12-01
- Inventor: Lourival Domingos POSSANI POSTAY , María Martha PEDRAZA ESCALONA , Gerardo Pavel ESPINO SOLIS , Alejandro OLVERA RODRÍGUEZ , Héctor Miguel CARDOSO TORRES
- Applicant: UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO
- Applicant Address: MX Distrito Federal
- Assignee: UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO
- Current Assignee: UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO
- Current Assignee Address: MX Distrito Federal
- Priority: MXMX/A/2013/007474 20130626
- International Application: PCT/MX2014/000093 WO 20140617
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/145 ; C12N7/00 ; A61K47/48
Abstract:
The invention relates to the production and the characterisation of new murine monoclonal antibodies that recognize the domain CTD-2 (SEQ ID NO: 1) of the cell receptor DEC-205 of dendritic cells in chickens (Gallus gallus), pigs, (Sus scrofa) and humans (Homo sapiens). The invention also relates to the capacity of the new antibodies to direct and modulate the immune response at different levels in chickens (Gallus gallus) and pigs (Sus scrofa), as well as recognising the receptor DEC-205 in dentritic cells and cell lines in humans, In addition, the invention is used to quickly produce a specific humoral immune response against Hemaglutinina H5 of the H5N2-type avian flu virus.
Public/Granted literature
- US09951135B2 Monoclonal antibodies against the DEC-205 receptor of chicken dendritic cells Public/Granted day:2018-04-24
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