公开(公告)号：US20210145884A1

公开(公告)日：2021-05-20

申请号：US17048587

申请日：2019-04-17

Applicant: UCL Business Ltd

Inventor： Hans Stauss ,  Graham P. Wright ,  Jenny L. McGovern

IPC: A61K35/17 ,  C07K14/725 ,  C07K14/74 ,  C12N5/0783

Abstract: The present invention relates to an engineered regulatory T cell (Treg) comprising a T cell receptor (TCR) which is capable of specifically binding to a myelin basic protein (MBP) peptide or variant or fragment thereof when the peptide is presented by a major histocompatibility complex (MHC) molecule. The present invention further relates to methods for providing an engineered Treg and to methods and uses of said engineered Treg and vectors and kits of vectors encoding said Treg.

公开(公告)号：US20210079425A1

公开(公告)日：2021-03-18

申请号：US17048239

申请日：2019-04-17

Applicant: UCL Business Ltd.,

Inventor： Hans Stauss ,  Jenny L. McGovern

IPC: C12N15/87 ,  C07K14/725 ,  C12N5/0783 ,  A61K35/17

Abstract: The present invention relates to a method for enhancing the ability of regulatory T cells (Tregs) to suppress immune responses comprising increasing FOXP3 expression in a population of Tregs.

公开(公告)号：US12227756B2

公开(公告)日：2025-02-18

申请号：US17048587

申请日：2019-04-17

Applicant: UCL Business Ltd

Inventor： Hans Stauss ,  Graham P. Wright ,  Jenny L. McGovern

IPC: A61K35/17 ,  A61K39/00 ,  C07K14/725 ,  C07K14/74 ,  C12N5/0783 ,  C12N15/87 ,  A61K35/12 ,  A61K38/00

Abstract: The present invention relates to an engineered regulatory T cell (Treg) comprising a T cell receptor (TCR) which is capable of specifically binding to a myelin basic protein (MBP) peptide or variant or fragment thereof when the peptide is presented by a major histocompatibility complex (MHC) molecule. The present invention further relates to methods for providing an engineered Treg and to methods and uses of said engineered Treg and vectors and kits of vectors encoding said Treg.

公开(公告)号：US20240384301A1

公开(公告)日：2024-11-21

申请号：US18792799

申请日：2024-08-02

Applicant: UCL BUSINESS LTD.

Inventor： Hans Stauss ,  Jenny L. McGovern

IPC: C12N15/87 ,  A61K35/12 ,  A61K35/17 ,  A61K38/00 ,  C07K14/725 ,  C07K14/74 ,  C12N5/0783

Abstract: The present invention relates to a method for enhancing the ability of regulatory T cells (Tregs) to suppress immune responses comprising increasing FOXP3 expression in a population of Tregs.

公开(公告)号：US12077774B2

公开(公告)日：2024-09-03

申请号：US17048239

申请日：2019-04-17

Applicant: UCL Business Ltd.

Inventor： Hans Stauss ,  Jenny L. McGovern

IPC: C12N15/87 ,  A61K35/12 ,  A61K35/17 ,  A61K38/00 ,  C07K14/725 ,  C07K14/74 ,  C12N5/0783

CPC classification number: C12N15/87 ,  A61K35/17 ,  C07K14/7051 ,  C07K14/70539 ,  C12N5/0637 ,  A61K2035/122 ,  A61K38/00 ,  C12N2510/00

Abstract: The present invention relates to a method for enhancing the ability of regulatory T cells (Tregs) to suppress immune responses comprising increasing FOXP3 expression in a population of Tregs.