公开(公告)号：US20190194725A1

公开(公告)日：2019-06-27

申请号：US16079450

申请日：2017-02-24

Applicant: UCL BUSINESS PLC

Inventor： Mahdad NOURSADEGHI ,  Jennifer ROE ,  Adrian MARTINEAU

IPC: C12Q1/689 ,  G01N33/68

CPC classification number: C12Q1/689 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2800/12 ,  G01N2800/26 ,  G01N2800/56

Abstract: The present invention relates to a method of determining the presence or absence of active tuberculosis in a sample, in particular, comprising determining the levels of one or more biomarkers selected from basic leucine zipper transcription factor ATF-like 2 (BATF2), cluster of differentiation 177 (CD177), haptoglobin (HP), immunoglobulin J chain (IGJ) and galectin 10 (CLC), in said sample. Uses of biomarkers of the invention and kits for performing the method of the invention are also described.