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公开(公告)号：US20180134728A1
公开(公告)日：2018-05-17
申请号：US15580059
申请日：2016-06-07
申请人： UCB Biopharma SPRL
发明人： Gareth Neil Brace , Prafulkumar Tulshibhai Chovatia , Gregory Foulkes , James Andrew Johnson , Severine Danielle Jones , Boris Kroeplien , Fabien Claude Lecomte , Pui Leng Loke , Martin Alexander Lowe , Ajay Mandal , Timothy John Norman , Christopher Francis Palmer , Yolanda Pérez-Fuertes , John Robert Porter , Donald Smyth , Giancarlo Trani , Muhammed Uddin , Zhaoning Zhu
IPC分类号： C07D498/04 , A61P29/00 , A61P25/00 , A61P3/00 , A61P27/02 , A61P23/00 , A61P9/00 , A61P35/00 , A61K31/5383 , C07D413/14 , A61K31/538 , C07D413/06 , C07D471/04 , C07D413/12 , A61K31/473 , A61K31/4375 , A61K31/4725 , A61K31/444 , A61K31/423 , A61K31/4545 , A61K31/55 , C07D519/00
CPC分类号： C07D498/04 , A61K31/423 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/473 , A61K31/538 , A61K31/5383 , A61K31/55 , A61P3/00 , A61P9/00 , A61P23/00 , A61P25/00 , A61P27/02 , A61P29/00 , A61P35/00 , C07D401/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D471/04 , C07D519/00
摘要： A series of substituted 3,4-di-hydro-2H-.1,4-benzoxazin-3-one derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：US20160297818A1
公开(公告)日：2016-10-13
申请号：US15100697
申请日：2014-12-08
申请人： UCB BIOPHARMA SPRL
IPC分类号： C07D473/00 , A61K31/5377
CPC分类号： C07D473/00 , A61K31/5377 , C07D473/32
摘要： A series of substituted purine derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
摘要翻译： 因此，作为人类TNFα活性的有效调节剂的一系列取代的嘌呤衍生物在治疗和/或预防各种人类疾病中是有益的，包括自身免疫性和炎症性疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱 眼部疾病; 和肿瘤疾病。
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公开(公告)号：US20200283416A1
公开(公告)日：2020-09-10
申请号：US15774332
申请日：2016-11-24
申请人： UCB Biopharma SPRL
发明人： Rebecca Louise Charlton , Teresa De Haro Garcia , Martin Alexander Lowe , Malcolm Maccoss , Trevor Morgan , Richard David Taylor , Zhaoning Zhu
IPC分类号： C07D403/10 , C07D471/04 , C07D417/10
摘要： A series of 2-imino-6-methyltetrahydropyrimidin-4(1H)-one derivatives, substituted in the 6-position by a phenyl moiety which in turn is meta-substituted by an optionally substituted unsaturated fused bicyclic ring system containing at least one nitrogen atom, being selective inhibitors of plasmepsin V activity, are beneficial as pharmaceutical agents, especially in the treatment of malaria.
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公开(公告)号：US09988383B2
公开(公告)日：2018-06-05
申请号：US15100697
申请日：2014-12-08
申请人： UCB BIOPHARMA SPRL
IPC分类号： C07D473/00 , C07D473/32 , A61K31/5377
CPC分类号： C07D473/00 , A61K31/5377 , C07D473/32
摘要： A series of substituted purine derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：US20150152065A1
公开(公告)日：2015-06-04
申请号：US14406848
申请日：2013-06-11
申请人： UCB Biopharma SPRL
发明人： Daniel Christopher Brookings , Mark Daniel Calmiano , Ellen Olivia Gallimore , Helen Tracey Horsley , Martin Clive Hutchings , James Andrew Johnson , Boris Kroeplien , Fabien Claude Lecomte , Martin Alexander Lowe , Timothy John Norman , John Robert Porter , Joanna Rachel Quincey , James Thomas Reuberson , Matthew Duncan Selby , Michael Alan Shaw , Zhaoning Zhu , Anne Marie Foley
IPC分类号： C07D235/12 , C07D401/04 , A61K31/4439 , A61K31/454 , C07D405/06 , A61K31/4192 , C07D403/04 , A61K31/4709 , A61K31/4725 , A61K31/444 , C07D401/14 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D491/107 , A61K31/506 , A61K31/4184
CPC分类号： C07D235/12 , A61K31/4184 , A61K31/4192 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/06 , C07D491/107
摘要： A series of benzimidazole derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
摘要翻译： 因此，作为人TNFα活性的有效调节剂的一系列苯并咪唑衍生物有益于治疗和/或预防各种人类疾病，包括自身免疫和炎性疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱 眼部疾病; 和肿瘤疾病。
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公开(公告)号：US10464932B2
公开(公告)日：2019-11-05
申请号：US16076387
申请日：2017-02-22
申请人： UCB Biopharma SPRL
发明人： Teresa De Haro Garcia , Martin Alexander Lowe , Malcolm Maccoss , Richard David Taylor , Zhaoning Zhu
IPC分类号： C07D417/10 , C07D417/14 , A61P33/06
摘要： A series of 3-imino-5-methyl-1,2,4-thiadiazinane 1,1-dioxide derivatives of formula (I), substituted in the 5-position by a phenyl moiety NH which in turn is meta-substituted by an optionally substituted fused bicyclic heteroaromatic ring system containing at least one nitrogen atom, being selective inhibitors of plasmepsin V activity, are beneficial as pharmaceutical agents, especially in the treatment of malaria.
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公开(公告)号：US20190040053A1
公开(公告)日：2019-02-07
申请号：US16076387
申请日：2017-02-22
申请人： UCB Biopharma SPRL
发明人： Teresa De Haro Garcia , Martin Alexander Lowe , Malcolm Maccoss , Richard David Taylor , Zhaoning Zhu
IPC分类号： C07D417/10 , C07D417/14 , A61P33/06
CPC分类号： C07D417/10 , A61P33/06 , C07D417/14
摘要： A series of 3-imino-5-methyl-1,2,4-thiadiazinane 1,1-dioxide derivatives of formula (I), substituted in the 5-position by a phenyl moiety NH which in turn is meta-substituted by an optionally substituted fused bicyclic heteroaromatic ring system containing at least one nitrogen atom, being selective inhibitors of plasmepsin V activity, are beneficial as pharmaceutical agents, especially in the treatment of malaria.
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公开(公告)号：US20150203486A1
公开(公告)日：2015-07-23
申请号：US14414287
申请日：2013-07-05
申请人： UCB Biopharma SPRL
发明人： Jonathan Mark Bentley , Daniel Christopher Brookings , Julien Alistair Brown , Thomas Paul Cain , Praful Tulshi Chovatia , Anne Marie Foley , Ellen Olivia Gallimore , Laura Jane Gleave , Alexander Heifetz , Helen Tracey Horsley , Martin Clive Hutchings , Victoria Elizabeth Jackson , James Andrew Johnson , Craig Johnstone , Boris Kroeplien , Fabien Claude Lecomte , Deborah Leigh , Martin Alexander Lowe , James Madden , John Robert Porter , Joanna Rachel Quincey , Laura Claire Reed , James Thomas Reuberson , Anthony John Richardson , Sarah Emily Richardson , Matthew Duncan Selby , Michael Alan Shaw , Zhaoning Zhu
IPC分类号： C07D471/04 , A61K31/496 , A61K31/506 , C07D491/107 , A61K31/5377 , A61K31/5513 , A61K31/554 , A61K31/437 , A61K31/541
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/5513 , A61K31/554 , C07D491/107 , C07D519/00
摘要： A series of imidazo[1,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
摘要翻译： 因此，作为人类TNFα活性的有效调节剂的一系列式（I）的咪唑并[1,2-a]吡啶衍生物因此有益于治疗和/或预防各种人类疾病，包括自身免疫和炎性疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱 眼部疾病; 和肿瘤疾病。
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公开(公告)号：US20190100525A1
公开(公告)日：2019-04-04
申请号：US16086408
申请日：2017-03-31
申请人： UCB Biopharma SPRL , Sanofi
发明人： Michael Louis Robert Deligny , Jag Paul Heer , Jean Keyaerts , Luce Elsa Lepissier , Martin Alexander Lowe
IPC分类号： C07D487/18
摘要： A series of substituted fused pentacyclic benzimidazole derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
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公开(公告)号：US09550737B2
公开(公告)日：2017-01-24
申请号：US14406848
申请日：2013-06-11
申请人： UCB Biopharma SPRL
发明人： Daniel Christopher Brookings , Mark Daniel Calmiano , Ellen Olivia Gallimore , Helen Tracey Horsley , Martin Clive Hutchings , James Andrew Johnson , Boris Kroeplien , Fabien Claude Lecomte , Martin Alexander Lowe , Timothy John Norman , John Robert Porter , Joanna Rachel Quincey , James Thomas Reuberson , Matthew Duncan Selby , Michael Alan Shaw , Zhaoning Zhu , Anne Marie Foley
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D491/107 , C07D235/12 , A61K31/4184 , A61K31/4192 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D405/06
CPC分类号： C07D235/12 , A61K31/4184 , A61K31/4192 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/06 , C07D491/107
摘要： A series of benzimidazole derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
摘要翻译： 因此，作为人TNFα活性的有效调节剂的一系列苯并咪唑衍生物有益于治疗和/或预防各种人类疾病，包括自身免疫和炎性疾病; 神经和神经退行性疾病; 疼痛和伤害性疾病; 心血管疾病; 代谢紊乱 眼部疾病; 和肿瘤疾病。
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