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公开(公告)号：US20240168026A1
公开(公告)日：2024-05-23
申请号：US18283274
申请日：2022-03-22
IPC分类号： G01N33/574 , C07K16/18
CPC分类号： G01N33/57438 , C07K16/18
摘要： The present invention provides a convenient and noninvasive detection method for assisting in the determination of pancreatic cystic tumor to be benign or malignant, and a kit for detection therefor. Specifically, the present invention provides a method for assisting in the determination of malignant pancreatic cystic tumor, the method comprising the steps of measuring in vitro the amount of APOA2-AT protein or/and APOA2-ATQ protein present in a body fluid sample of a test subject having pancreatic cystic tumor, and assisting in determining the pancreatic cystic tumor to be benign or malignant on the basis of the amount, and a kit for assisting in the determination of malignant pancreatic cystic tumor, the kit being directed to measuring the amount of APOA2-AT protein or/and APOA2-ATQ protein and being usable in the method.
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公开(公告)号：US11162956B2
公开(公告)日：2021-11-02
申请号：US15555031
申请日：2016-03-01
发明人： Michimoto Kobayashi , Mitsuaki Sanada , Yoshiyuki Sasajima , Giman Jung , Tesshi Yamada , Kazufumi Honda
IPC分类号： G01N33/68 , C07K16/18 , C07K14/775 , G01N33/574
摘要： The purpose of the present invention is to provide a simple and highly accurate method for detecting pancreatic exocrine dysfunction with minimal invasiveness to a subject. The method comprising in vitro measurement of two APOA2 protein variants, mutants thereof and/or fragments thereof in a body fluid sample derived from the subject and detection of the presence or absence of pancreatic exocrine dysfunction on the basis of the measured amounts, and a detection kit for pancreatic exocrine dysfunction including antibodies that can specifically bind to said proteins are provided.
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公开(公告)号：US20220120752A1
公开(公告)日：2022-04-21
申请号：US17563148
申请日：2021-12-28
发明人： Mitsuaki Sanada , Michimoto Kobayashi , Aiko Takayama , Yoshiyuki Sasajima , Giman Jung , Tesshi Yamada , Kazufumi Honda
IPC分类号： G01N33/574 , G01N33/577 , G01N33/53 , C07K16/18
摘要： The present invention provides a method for detecting biliary tract cancer by measuring the amounts of APOA2 protein variants in a test sample with anti-APOA2 antibodies, the anti-APOA2 antibodies for use in the above method and a detection kit for biliary tract cancer including the above antibodies.
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公开(公告)号：US20220011322A1
公开(公告)日：2022-01-13
申请号：US17487089
申请日：2021-09-28
发明人： Michimoto Kobayashi , Mitsuaki Sanada , Yoshiyuki Sasajima , Giman Jung , Tesshi Yamada , Kazufumi Honda
IPC分类号： G01N33/68 , C07K16/18 , C07K14/775 , G01N33/574
摘要： The purpose of the present invention is to provide a simple and highly accurate method for detecting pancreatic exocrine dysfunction with minimal invasiveness to a subject. The method comprising in vitro measurement of two APOA2 protein variants, mutants thereof and/or fragments thereof in a body fluid sample derived from the subject and detection of the presence or absence of pancreatic exocrine dysfunction on the basis of the measured amounts, and a detection kit for pancreatic exocrine dysfunction including antibodies that can specifically bind to said proteins are provided.
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公开(公告)号：US20180031574A1
公开(公告)日：2018-02-01
申请号：US15555031
申请日：2016-03-01
发明人： Michimoto Kobayashi , Mitsuaki Sanada , Yoshiyuki Sasajima , Giman Jung , Tesshi Yamada , Kazufumi Honda
CPC分类号： G01N33/6893 , C07K14/775 , C07K16/18 , G01N33/57438 , G01N2333/775 , G01N2800/06 , G01N2800/067
摘要： The purpose of the present invention is to provide a simple and highly accurate method for detecting pancreatic exocrine dysfunction with minimal invasiveness to a subject. The method comprising in vitro measurement of two APOA2 protein variants, mutants thereof and/or fragments thereof in a body fluid sample derived from the subject and detection of the presence or absence of pancreatic exocrine dysfunction on the basis of the measured amounts, and a detection kit for pancreatic exocrine dysfunction including antibodies that can specifically bind to said proteins are provided.
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公开(公告)号：US20180017564A1
公开(公告)日：2018-01-18
申请号：US15546178
申请日：2016-01-25
发明人： Mitsuaki Sanada , Michimoto Kobayashi , Aiko Takayama , Yoshiyuki Sasajima , Giman Jung , Tesshi Yamada , Kazufumi Honda
IPC分类号： G01N33/574 , C07K16/18
CPC分类号： G01N33/57446 , C07K16/18 , C07K2317/565 , G01N33/53 , G01N33/574 , G01N33/577 , G01N2333/775
摘要： The present invention provides a method for detecting biliary tract cancer by measuring the amounts of APOA2 protein variants in a test sample with anti-APOA2 antibodies, the anti-APOA2 antibodies for use in the above method and a detection kit for biliary tract cancer including the above antibodies.
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公开(公告)号：US11733250B2
公开(公告)日：2023-08-22
申请号：US17487089
申请日：2021-09-28
发明人： Michimoto Kobayashi , Mitsuaki Sanada , Yoshiyuki Sasajima , Giman Jung , Tesshi Yamada , Kazufumi Honda
IPC分类号： G01N33/68 , C07K16/18 , C07K14/775 , G01N33/574
CPC分类号： G01N33/6893 , C07K14/775 , C07K16/18 , G01N33/57438 , G01N2333/775 , G01N2800/06 , G01N2800/067
摘要： The purpose of the present invention is to provide a simple and highly accurate method for detecting pancreatic exocrine dysfunction with minimal invasiveness to a subject. The method comprising in vitro measurement of two APOA2 protein variants, mutants thereof and/or fragments thereof in a body fluid sample derived from the subject and detection of the presence or absence of pancreatic exocrine dysfunction on the basis of the measured amounts, and a detection kit for pancreatic exocrine dysfunction including antibodies that can specifically bind to said proteins are provided.
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公开(公告)号：US11231423B2
公开(公告)日：2022-01-25
申请号：US15546178
申请日：2016-01-25
发明人： Mitsuaki Sanada , Michimoto Kobayashi , Aiko Takayama , Yoshiyuki Sasajima , Giman Jung , Tesshi Yamada , Kazufumi Honda
IPC分类号： G01N33/574 , G01N33/577 , G01N33/53 , C07K16/18
摘要： The present invention provides a method for detecting biliary tract cancer by measuring the amounts of APOA2 protein variants in a test sample with anti-APOA2 antibodies, the anti-APOA2 antibodies for use in the above method and a detection kit for biliary tract cancer including the above antibodies.
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