公开(公告)号：US07905339B2

公开(公告)日：2011-03-15

申请号：US11987171

申请日：2007-11-28

申请人： Tomoki Ito ,  Kazuyoshi Miyahara ,  Nobuo Yamazaki

发明人： Tomoki Ito ,  Kazuyoshi Miyahara ,  Nobuo Yamazaki

IPC分类号： B60K23/02

CPC分类号： A01B33/082 ,  A01B33/028 ,  B62D51/001 ,  B62D51/002 ,  F16D23/12 ,  Y10T74/20213

摘要： Operation mechanism of a working machine includes a main clutch lever pivotably provided on an operating handle, and a pivot member operable in interlocked relation to pivoting operation of the main clutch lever. The pivot member pivots about a pivot point differing in position from a pivot point of the main clutch lever. When fully pulled by pivoting operation of the main clutch lever, the cable member is located nearest to the pivot point of the pivot member, so that force reverse-pivoting the pivot member is reduced.

摘要翻译： 工作机械的操作机构包括可枢转地设置在操作手柄上的主离合器杆和可与主离合杆的枢转操作联动操作的枢转构件。 枢转构件围绕与主离合器杆的枢转点不同的枢转点枢转。 当通过主离合器杆的枢转操作完全拉动时，电缆构件定位成最靠近枢转构件的枢转点，使得枢转构件的反向枢转力减小。

公开(公告)号：US08605362B2

公开(公告)日：2013-12-10

申请号：US13033681

申请日：2011-02-24

申请人： Tomoki Ito

发明人： Tomoki Ito

IPC分类号： G02B15/14

CPC分类号： G02B15/173 ,  G02B27/646

摘要： A zoom lens system includes, in order from an object side: a first lens group having positive refractive power; a second lens group having negative refractive power; a third lens group having positive refractive power; a fourth lens group having negative refractive power; and a fifth lens group having positive refractive power. Upon zooming from a wide-angle end state to a telephoto end state, a position of the first lens group is fixed. At least a portion of any one of the lens groups is moved in a direction including a component perpendicular to an optical axis, and a given conditional expression is satisfied, thereby providing a zoom lens system capable of excellently suppressing variation in aberrations upon zooming and upon correcting an image blur, an optical apparatus including the zoom lens system, and a method for manufacturing the zoom lens system.

摘要翻译： 变焦透镜系统从物体侧依次包括具有正折射光焦度的第一透镜组; 具有负屈光力的第二透镜组; 具有正折射力的第三透镜组; 具有负屈光力的第四透镜组; 以及具有正屈光力的第五透镜组。 当从广角端状态变焦到长焦端状态时，第一透镜组的位置是固定的。 任何一个透镜组的至少一部分在包括垂直于光轴的分量的方向上移动，并且满足给定的条件表达式，从而提供能够极好地抑制变焦和随后的像差变化的变焦透镜系统 校正图像模糊，包括变焦透镜系统的光学装置以及用于制造变焦透镜系统的方法。

公开(公告)号：US20110048818A1

公开(公告)日：2011-03-03

申请号：US12991306

申请日：2009-04-03

申请人： Hideaki Kobayashi ,  Tomoki Ito

发明人： Hideaki Kobayashi ,  Tomoki Ito

IPC分类号： B62D51/04 ,  A01B33/02 ,  A01B33/08 ,  B60K15/063

CPC分类号： B60K15/07 ,  A01B33/028 ,  A01B33/16 ,  B60Y2200/41 ,  F17C13/085 ,  F17C2205/0111 ,  F17C2205/0165 ,  F17C2221/035 ,  F17C2223/0153 ,  F17C2223/033 ,  F17C2270/0736

摘要： A walking-type working machine in which a gas-container housing section (cassette-type gas container) and a carry handle are mounted to a handle post. The walking-type working machine (10) is provided with a cassette-type gas container (21) mounted to a handle post (16), which rises upward and rearward from a rear section (11a) of a working machine body (11), so as to be oriented in the longitudinal direction of the handle post. A gas engine (21) is driven by fuel in the cassette-type gas container (21). The walking-type working machine is provided with a carry handle (22) for carrying the machine. The carry handle (22) is mounted to the handle post and is formed so as to surround the cassette-type gas container. The carry handle has a grip (45).

摘要翻译： 一种行走式作业机，其中将气体容器收纳部（盒式气体容器）和携带手柄安装在手柄柱上。 步行式加工机10具有安装在从工作机体11的后部11a上下升起的手柄16的盒式气体容器21， 以便在手柄柱的纵向方向上定向。 燃气发动机（21）由盒式气体容器（21）中的燃料驱动。 步行式工作机器设置有用于承载机器的便携手柄（22）。 携带把手（22）安装在手柄柱上并形成为围绕盒式气体容器。 手柄具有握把（45）。

公开(公告)号：US20090086321A1

公开(公告)日：2009-04-02

申请号：US12211900

申请日：2008-09-17

申请人： Keiko MIZUGUCHI ,  Tomoki Ito

发明人： Keiko MIZUGUCHI ,  Tomoki Ito

IPC分类号： G02B27/64 ,  G02B15/16

CPC分类号： G02B27/646 ,  G02B15/173

摘要： Providing a zoom lens system having a vibration reduction function capable of performing quick focusing with excellent optical performance even upon vibration reduction. The system including, in order from an object, a first lens group G1 having positive refractive power, a second lens group G2 having negative refractive power, a third lens group G3 having positive refractive power, and a fourth lens group G4 having positive refractive power. Upon zooming from a wide-angle end state to a telephoto end state, a distance between the first lens group G1 and the second lens group G2 varies, and a distance between the second lens group G2 and the third lens group G3 varies. The third lens group G3 carries out focusing from an infinity object to a close object. At least a portion of the fourth lens group G4 moves in a direction perpendicular to the optical axis.

摘要翻译： 提供具有减振功能的变焦透镜系统，即使在减振时也能够进行快速聚焦，具有出色的光学性能。 该系统依次包括具有正折光力的第一透镜组G1，具有负折光力的第二透镜组G2，具有正折光力的第三透镜组G3和具有正折光力的第四透镜组G4 。 在从广角端状态变焦到望远端状态时，第一透镜组G1和第二透镜组G2之间的距离变化，并且第二透镜组G2与第三透镜组G3之间的距离变化。 第三透镜组G3从无限远物体执行聚焦到近距离物体。 第四透镜组G4的至少一部分在垂直于光轴的方向上移动。

公开(公告)号：US20080286286A1

公开(公告)日：2008-11-20

申请号：US11659266

申请日：2007-01-16

申请人： Yong-Jun Liu ,  Tomoki Ito

发明人： Yong-Jun Liu ,  Tomoki Ito

IPC分类号： A61K39/395 ,  G01N33/535 ,  A61P37/02

CPC分类号： A61K38/177 ,  C07K16/2878 ,  G01N33/505 ,  G01N33/56972 ,  G01N2333/5428

摘要： OX40L inhibits the generation of IL-10-producing Tr1 cells from naïve and memory CD4+ T cells induced by the immunuosuppressive drugs dexamethasone and vitamin D3. This unique function of OX40L is not shared by two other costimulatory TNF-family members, GITR-ligand and 4-1BB-ligand. OX40L also strongly inhibits the generation of IL-10-producing Tr1 cells induced by two physiological stimuli provided by inducible costimulatory ligand and immature DCs and inhibits the production of IL-10 by regulatory T cells. It has thus been shown that signaling the OX40-receptor on human T cells by monoclonal antibodies, small molecules, or OX40L regulates the generation and function of IL-10 producing immunosuppressive T cells. Also provided are high throughput methods for identifying substances that promote or inhibit the generation and function of IL-10 producing T cells. Numerous disease states, such as human allergic, autoimmune, and autoimmune diseases, and cancer, may be treated by targeting OX40/OX40L.

摘要翻译： OX40L抑制由免疫抑制药物地塞米松和维生素D3诱导的初始和记忆的CD4 + T细胞产生产生IL-10的Tr1细胞。 OX40L的这种独特功能不是由另外两种共刺激的TNF-家族成员，GITR-配体和4-1BB-配体共享。 OX40L还强烈地抑制由诱导性共刺激配体和未成熟DC提供的两种生理刺激诱导的产生IL-10的Tr1细胞的产生，并通过调节性T细胞抑制IL-10的产生。 因此，已经表明，通过单克隆抗体，小分子或OX40L信号传导人T细胞上的OX40-受体调节产生IL-10的免疫抑制性T细胞的产生和功能。 还提供了用于鉴定促进或抑制产生IL-10和产生T细胞的功能的物质的高通量方法。 可以通过靶向OX40 / OX40L来治疗许多疾病状态，例如人类过敏，自身免疫和自身免疫性疾病和癌症。

公开(公告)号：US08611761B2

公开(公告)日：2013-12-17

申请号：US12984095

申请日：2011-01-04

申请人： Ryutaro Takei ,  Takeshi Irie ,  Tomoki Ito ,  Kazuhisa Ozaki ,  Masatsugu Togasaki

发明人： Ryutaro Takei ,  Takeshi Irie ,  Tomoki Ito ,  Kazuhisa Ozaki ,  Masatsugu Togasaki

IPC分类号： H04B10/00 ,  H04B10/50

CPC分类号： H04B10/503 ,  H04B10/572

摘要： New method to control the optical transmitter is disclosed. The optical transmitter provides both of the ATC feedback loop and the APC feedback loop. When a failure occurs in the ATC feedback loop and the temperature sensor is unable to output an adequate signal any longer, the optical transmitter cuts the APC loop and operates the LD in constant conditions. The output of the monitor PD is transferred to the ATC loop to control the TEC based on the optical output of the LD.

摘要翻译： 公开了一种控制光发射机的新方法。 光发射机提供ATC反馈环路和APC反馈环路。 当ATC反馈回路发生故障，温度传感器不能再输出足够的信号时，光发射器切断APC回路并在恒定条件下操作LD。 监视器PD的输出被传送到ATC环路，以基于LD的光输出来控制TEC。

公开(公告)号：US20130258495A1

公开(公告)日：2013-10-03

申请号：US13994730

申请日：2011-12-14

申请人： Tomoki Ito

发明人： Tomoki Ito

IPC分类号： G02B15/16

CPC分类号： G02B15/16 ,  G02B15/173 ,  G02B27/646 ,  Y10T29/49826

摘要： A zoom optical system ZL to be mounted on an optical apparatus such as a single lens reflex camera 1, comprising, in order from an object side, a first lens group G1 having positive refractive power, a second lens group G2 having negative refractive power, a third lens group G3 having positive refractive power, a fourth lens group G4 having negative refractive power, a fifth lens group G5 having positive refractive power, and a sixth lens group G6 having negative refractive power. The zoom optical system is configured such that at least a portion of any one lens group among these lens group G1 to G6 may be moved such that a component in a direction perpendicular to the optical axis may be included. Thus, there are provided a zoom optical system that can suppress well variation in aberrations upon zooming, an optical apparatus equipped therewith and a method for manufacturing the zoom optical system.

摘要翻译： 安装在诸如单个透镜反射照相机1的光学装置上的变焦光学系统ZL包括从物体侧开始具有正折光力的第一透镜组G1，具有负折光力的第二透镜组G2， 具有正折光力的第三透镜组G3，具有负折光力的第四透镜组G4，具有正折光力的第五透镜组G5和具有负折光力的第六透镜组G6。 变焦光学系统被配置为使得这些透镜组G1至G6中的任何一个透镜组的至少一部分可以移动，使得可以包括在垂直于光轴的方向上的分量。 因此，提供了可以抑制变焦时的像差的良好变化的变焦光学系统，配备有其的光学装置以及用于制造变焦光学系统的方法。

公开(公告)号：US08066081B2

公开(公告)日：2011-11-29

申请号：US12622050

申请日：2009-11-19

申请人： Tomoki Ito ,  Koichi Azuma ,  Tomomi Nakaya ,  Masayuki Sasaoka

发明人： Tomoki Ito ,  Koichi Azuma ,  Tomomi Nakaya ,  Masayuki Sasaoka

IPC分类号： A01B33/00

CPC分类号： A01B33/028

摘要： A small-sized tiller includes a stand unit configured to solely support the tiller in a self-standing state. The stand unit has a pole portion removably mountable to a resistance-bar attachment portion of the body frame when a resistance bar has been removed from the resistance-bar attachment portion.

摘要翻译： 一种小型耕作机包括一个支架单元，该支架单元被配置为仅在独立状态下支撑耕作机。 当电阻杆从电阻杆安装部分移除时，支架单元具有可拆卸地安装到主体框架的电阻杆附接部分的极部分。

公开(公告)号：US20110008368A1

公开(公告)日：2011-01-13

申请号：US12861135

申请日：2010-08-23

申请人： Yong-Jun Liu ,  Tomoki Ito

发明人： Yong-Jun Liu ,  Tomoki Ito

IPC分类号： A61K39/395 ,  A61P35/00 ,  A61P37/04 ,  C40B30/04

CPC分类号： G01N33/5011 ,  A61K2039/505 ,  C07K16/2878 ,  C07K2317/73 ,  C07K2317/75 ,  G01N2333/5434 ,  G01N2333/70578

摘要： Numerous disease states, such as human allergic, autoimmune, and autoimmune diseases, and cancer, may be treated by targeting OX40/OX4OL. OX4OL inhibits the generation of Tr1 cells from naïve and memory CD4+ T cells. This unique function of OX4OL is not shared by two other costimulatory TNF-family members, GITR-ligand and 4-1BB-ligand. It has been shown that signaling the OX40-receptor on human T cells by antibodies, small molecules, or the OX4OL modulates the generation and function of IL-10 producing Foxp3+ Treg immunosuppressive T cells and blocks Foxp3+ Treg function. Further, provided are high throughput methods for identifying compounds that can inhibit the immunosuppressive function of IL-10 producing Tr1 cells.

摘要翻译： 可以通过靶向OX40 / OX4OL来治疗许多疾病状态，例如人类过敏，自身免疫和自身免疫性疾病以及癌症。 OX4OL抑制从初始和记忆的CD4 + T细胞产生Tr1细胞。 OX4OL的这种独特功能不是由另外两种共刺激的TNF-家族成员GITR-配体和4-1BB-配体共享。 已经表明，通过抗体，小分子或OX4OL来传递人T细胞上的OX40-受体，调节产生IL-10的产生和功能的Foxp3 + Treg免疫抑制性T细胞并阻断Foxp3 + Treg功能。 此外，提供了用于鉴定可以抑制产生IL-10的Tr1细胞的免疫抑制功能的化合物的高通量方法。

公开(公告)号：US20090159600A1

公开(公告)日：2009-06-25

申请号：US12343668

申请日：2008-12-24

申请人： Hideaki Kobayashi ,  Masayuki Sasaoka ,  Tomoki Ito

发明人： Hideaki Kobayashi ,  Masayuki Sasaoka ,  Tomoki Ito

IPC分类号： B65D88/06

CPC分类号： A01B33/028 ,  F17C13/08 ,  F17C13/085 ,  F17C2201/0104 ,  F17C2201/032 ,  F17C2201/037 ,  F17C2201/058 ,  F17C2203/012 ,  F17C2205/0111 ,  F17C2205/0115 ,  F17C2205/0126 ,  F17C2205/0161 ,  F17C2205/0165 ,  F17C2205/0173 ,  F17C2205/0308 ,  F17C2209/221 ,  F17C2209/228 ,  F17C2221/035 ,  F17C2270/07

摘要： Gas canister retaining structure includes: a gas canister cover pivotable between an opened position for attaching/detaching a cassette gas canister to/from the retaining structure and a closed position for accommodating and holding the gas canister in place within the canister cover; a mouthpiece support section provided inside the gas canister cover for supporting a mouthpiece portion of the cassette gas canister with a jet nozzle of the cassette gas canister received in a nozzle receiving port provided in the mouthpiece support section; and a shutter member pivotable between an opened position for opening the nozzle receiving port and a closed position for closing the nozzle receiving port.

摘要翻译： 燃气罐保持结构包括：气罐盖，其可在用于将盒式气体罐与保持结构连接/拆卸的打开位置和用于将气罐容纳并保持在罐盖内的适当位置的关闭位置之间枢转; 一个接口支撑部分，设置在气体罐盖内部，用于通过设置在接口支撑部分中的喷嘴接收端口中的盒式气体罐的喷嘴支撑盒式气体罐的接口部分; 以及活门构件，其能够在用于打开所述喷嘴接收口的打开位置和用于关闭所述喷嘴接收口的关闭位置之间枢转。