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1.发明授权公开(公告)号：US08938292B2
公开(公告)日：2015-01-20
申请号：US12263065
申请日：2008-10-31
CPC分类号： A61N1/36521 , A61B5/021 , A61B5/0215 , A61B5/02158 , A61B5/053 , A61B5/0535 , A61B5/0538 , A61B5/7239 , A61N1/36564
摘要： Techniques for estimating a cardiac chamber or vascular pressure based upon impedance are described. A device or system may measure an impedance between at least two electrodes implanted within or proximate to a cardiovascular system. The device or system may estimate a pressure of an element of the cardiovascular system based on a relationship between impedance and volume of the element, and based on a empirical relationship between the volume and the pressure. The device or system may also estimate the dimension of the element based on the impedance-volume relationship, or other characteristics based on the impedance. Because the impedance measurements may be obtained, in some examples, by using electrodes and leads implanted within the cardiovascular system and coupled to an implantable medical device, a practical estimation of a cardiovascular pressure can be obtained on a chronic basis without requiring the use other invasive sensors, such as micronanometer transducers.
摘要翻译： 描述了基于阻抗估计心室或血管压力的技术。 装置或系统可以测量植入在心血管系统内或其附近的至少两个电极之间的阻抗。 装置或系统可以基于元件的阻抗和体积之间的关系，并且基于体积和压力之间的经验关系来估计心血管系统的元件的压力。 装置或系统还可以基于阻抗 - 体积关系或基于阻抗的其它特性来估计元件的尺寸。 由于可以获得阻抗测量值，在一些示例中，通过使用植入心血管系统内并连接到可植入医疗装置的电极和引线，可以长期获得心血管压力的实际估计，而不需要使用其它侵入性 传感器，如微量计传感器。
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公开(公告)号：US08744565B2
公开(公告)日：2014-06-03
申请号：US12112765
申请日：2008-04-30
IPC分类号： A61B5/00
CPC分类号： A61B5/0809 , A61B5/053 , A61B5/0538 , A61B5/4869 , A61B5/686 , A61B5/7257 , A61N1/36521
摘要： A system and method is provided to measure intrathoracic complex impedance and to identify and indicate disease conditions based on the impedance measurements. Multiple impedance vectors may betaken into account, and an optimal vector may be selected to provide the most useful impedance measurement for the identification and indication of disease conditions.
摘要翻译： 提供了一种系统和方法来测量胸腔内复合阻抗，并根据阻抗测量来识别和指示疾病状况。 可以考虑多个阻抗向量，并且可以选择最佳向量以提供用于疾病状况的识别和指示的最有用的阻抗测量。
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公开(公告)号：US20110190654A1
公开(公告)日：2011-08-04
申请号：US12696753
申请日：2010-01-29
IPC分类号： A61B5/053
CPC分类号： A61N1/36521 , A61B5/0031 , A61B5/0215 , A61B5/02405 , A61B5/053 , A61B5/08 , A61B5/11 , A61B5/1116 , A61B5/4035 , A61N1/36535 , A61N1/37247 , A61N1/37258
摘要： The disclosure describes techniques for quantifying the autonomic nervous system (ANS) health of a patient with thoracic impedance measurements. Thoracic impedance may be measured utilizing cardiac electrodes and an implantable medical device housing or other electrodes located on or within the patient. Since greater variability in thoracic impedance may indicate better health of the ANS, monitoring impedance changes in a patient may be used to quantify autonomic tone of the ANS, and ultimately, overall patient health. In some examples, thoracic impedance may be measured in response to a change in patient posture for acute monitoring or at predetermined times over several days, weeks, or months for more chronic monitoring of the patient. An implantable medical device may independently analyze the impedance measurements and transmit an alert to the patient or clinician when impedance changes indicate a change in patient health.
摘要翻译： 本公开描述了用于量化具有胸部阻抗测量的患者的自主神经系统（ANS）健康的技术。 可以使用心电极和位于患者内部或内部的可植入医疗装置外壳或其它电极来测量胸腔阻抗。 由于胸部阻抗变化较大可能表明ANS的健康状况良好，所以监测患者的阻抗变化可用于量化ANS的自主音调，并最终对整体患者的健康状况进行量化。 在一些示例中，可以响应于用于急性监测的患者姿势的变化或在几天，几周或几个月的预定时间来测量胸部阻抗以进行更长期的患者监测。 当阻抗变化表示患者健康状况发生变化时，植入式医疗设备可以独立地分析阻抗测量结果并向患者或临床医生发送警报。
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公开(公告)号：US08435186B2
公开(公告)日：2013-05-07
申请号：US12696753
申请日：2010-01-29
IPC分类号： A61B5/00
CPC分类号： A61N1/36521 , A61B5/0031 , A61B5/0215 , A61B5/02405 , A61B5/053 , A61B5/08 , A61B5/11 , A61B5/1116 , A61B5/4035 , A61N1/36535 , A61N1/37247 , A61N1/37258
摘要： The disclosure describes techniques for quantifying the autonomic nervous system (ANS) health of a patient with thoracic impedance measurements. Thoracic impedance may be measured utilizing cardiac electrodes and an implantable medical device housing or other electrodes located on or within the patient. Since greater variability in thoracic impedance may indicate better health of the ANS, monitoring impedance changes in a patient may be used to quantify autonomic tone of the ANS, and ultimately, overall patient health. In some examples, thoracic impedance may be measured in response to a change in patient posture for acute monitoring or at predetermined times over several days, weeks, or months for more chronic monitoring of the patient. An implantable medical device may independently analyze the impedance measurements and transmit an alert to the patient or clinician when impedance changes indicate a change in patient health.
摘要翻译： 本公开描述了用于量化具有胸部阻抗测量的患者的自主神经系统（ANS）健康的技术。 可以使用心电极和位于患者内部或内部的可植入医疗装置外壳或其它电极来测量胸腔阻抗。 由于胸部阻抗变化较大可能表明ANS的健康状况良好，所以监测患者的阻抗变化可用于量化ANS的自主音调，并最终对整体患者的健康状况进行量化。 在一些示例中，可以响应于用于急性监测的患者姿势的变化或在几天，几周或几个月的预定时间来测量胸部阻抗以进行更长期的患者监测。 当阻抗变化表示患者健康状况发生变化时，植入式医疗设备可以独立地分析阻抗测量结果并向患者或临床医生发送警报。
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5.发明申请公开(公告)号：US20100030087A1
公开(公告)日：2010-02-04
申请号：US12263065
申请日：2008-10-31
IPC分类号： A61B5/0215 , A61B5/053
CPC分类号： A61N1/36521 , A61B5/021 , A61B5/0215 , A61B5/02158 , A61B5/053 , A61B5/0535 , A61B5/0538 , A61B5/7239 , A61N1/36564
摘要： Techniques for estimating a cardiac chamber or vascular pressure based upon impedance are described. A device or system may measure an impedance between at least two electrodes implanted within or proximate to a cardiovascular system. The device or system may estimate a pressure of an element of the cardiovascular system based on a relationship between impedance and volume of the element, and based on a empirical relationship between the volume and the pressure. The device or system may also estimate the dimension of the element based on the impedance-volume relationship, or other characteristics based on the impedance. Because the impedance measurements may be obtained, in some examples, by using electrodes and leads implanted within the cardiovascular system and coupled to an implantable medical device, a practical estimation of a cardiovascular pressure can be obtained on a chronic basis without requiring the use other invasive sensors, such as micronanometer transducers.
摘要翻译： 描述了基于阻抗估计心室或血管压力的技术。 装置或系统可以测量植入在心血管系统内或其附近的至少两个电极之间的阻抗。 装置或系统可以基于元件的阻抗和体积之间的关系，并且基于体积和压力之间的经验关系来估计心血管系统的元件的压力。 装置或系统还可以基于阻抗 - 体积关系或基于阻抗的其它特性来估计元件的尺寸。 由于可以获得阻抗测量值，在一些示例中，通过使用植入心血管系统内并连接到可植入医疗装置的电极和引线，可以长期获得心血管压力的实际估计，而不需要使用其它侵入性 传感器，如微量计传感器。
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公开(公告)号：US20090270934A1
公开(公告)日：2009-10-29
申请号：US12108818
申请日：2008-04-24
IPC分类号： A61N1/39
CPC分类号： A61N1/36585 , A61B5/0215 , A61B5/0402 , A61B5/053 , A61N1/36521 , A61N1/36564
摘要： An implantable cardioverter defibrillator evaluates the hemodynamic stability of an arrhythmia to determine whether or not to defibrillate. The device obtains cardiac pressure and cardiac impedance data and evaluates a phase relationship between these parameters. Hemodynamically stable rhythms will result in an out of phase relationship.
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公开(公告)号：US20090270933A1
公开(公告)日：2009-10-29
申请号：US12108785
申请日：2008-04-24
申请人： Douglas A. Hettrick , Kevin P. Vincent , Shantanu Sarkar , Yong-yo K.Y. Cho , Todd M. Zielinski
发明人： Douglas A. Hettrick , Kevin P. Vincent , Shantanu Sarkar , Yong-yo K.Y. Cho , Todd M. Zielinski
IPC分类号： A61N1/39
CPC分类号： A61N1/36585 , A61B5/0535 , A61B5/0538 , A61B5/7264 , A61N1/00 , A61N1/36521 , A61N1/36564 , A61N1/3962
摘要： An implantable cardioverter defibrillator evaluates the hemodynamic stability of an arrhythmia to determine whether or not to defibrillate. The device obtains cardiac pressure and cardiac impedance data and evaluates a phase relationship between these parameters. Hemodynamically stable rhythms will result in an out of phase relationship.
摘要翻译： 植入式心律转复除颤器评估心律失常的血液动力学稳定性，以确定是否除颤。 该装置获得心脏压力和心脏阻抗数据，并评估这些参数之间的相位关系。 血液动力学稳定的节律将导致异相关系。
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公开(公告)号：US20120109245A1
公开(公告)日：2012-05-03
申请号：US12916012
申请日：2010-10-29
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61B5/0452 , A61B5/0535 , A61B5/7239 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3987
摘要： Methods and/or devices are disclosed herein for monitoring cardiac impedance signal and delivering therapy to a patient's heart based upon the monitored cardiac impedance.
摘要翻译： 本文公开了用于监测心脏阻抗信号并基于所监测的心脏阻抗将治疗递送到患者心脏的方法和/或装置。
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公开(公告)号：US08639328B2
公开(公告)日：2014-01-28
申请号：US12916012
申请日：2010-10-29
IPC分类号： A61N1/00
CPC分类号： A61N1/36521 , A61B5/0452 , A61B5/0535 , A61B5/7239 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3987
摘要： Methods and/or devices are disclosed herein for monitoring cardiac impedance signal and delivering therapy to a patient's heart based upon the monitored cardiac impedance.
摘要翻译： 本文公开了用于监测心脏阻抗信号并基于所监测的心脏阻抗将治疗递送到患者心脏的方法和/或装置。
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公开(公告)号：US08478400B2
公开(公告)日：2013-07-02
申请号：US12108818
申请日：2008-04-24
IPC分类号： A61N1/39
CPC分类号： A61N1/36585 , A61B5/0215 , A61B5/0402 , A61B5/053 , A61N1/36521 , A61N1/36564
摘要： An implantable cardioverter defibrillator evaluates the hemodynamic stability of an arrhythmia to determine whether or not to defibrillate. The device obtains cardiac pressure and cardiac impedance data and evaluates a phase relationship between these parameters. Hemodynamically stable rhythms will result in an out of phase relationship.
摘要翻译： 植入式心律转复除颤器评估心律失常的血液动力学稳定性，以确定是否除颤。 该装置获得心脏压力和心脏阻抗数据，并评估这些参数之间的相位关系。 血液动力学稳定的节律将导致异相关系。
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