公开(公告)号：US09278163B2

公开(公告)日：2016-03-08

申请号：US14506426

申请日：2014-10-03

申请人： Titan Pharmaceuticals, Inc.

发明人： Rajesh A. Patel ,  Louis R. Bucalo ,  Lauren Costantini ,  Sofie Kleppner

IPC分类号： A61L31/16 ,  A61K9/00 ,  A61K9/14 ,  A61K9/16 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/428 ,  A61K31/48 ,  A61K31/485 ,  A61L31/04 ,  A61K31/198 ,  A61L31/10 ,  A61L31/12 ,  A61L31/14

CPC分类号： A61L31/16 ,  A61K9/0024 ,  A61K9/146 ,  A61K9/1635 ,  A61K31/198 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/428 ,  A61K31/48 ,  A61K31/485 ,  A61L31/048 ,  A61L31/10 ,  A61L31/125 ,  A61L31/146 ,  A61L2300/20 ,  A61L2300/40 ,  A61L2300/41 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/62 ,  A61L2420/04 ,  C08L31/04

摘要： The present invention provides compositions, methods, and kits for treatment of Parkinson's disease and other conditions for which treatment with a dopamine agonist is therapeutically beneficial. The invention provides a biocompatible nonerodible polymeric device which releases dopamine agonist continuously with generally linear release kinetics for extended periods of time. Dopamine agonist is released through pores that open to the surface of the polymeric matrix in which it is encapsulated. The device may be administered subcutaneously to an individual in need of continuous treatment with dopamine agonist.

摘要翻译： 本发明提供了用于治疗帕金森病的组合物，方法和试剂盒以及用多巴胺激动剂治疗是治疗有益的其它病症。 本发明提供了一种生物相容的非可溶性聚合物装置，其可延长释放动力学持续释放多巴胺激动剂。 多巴胺激动剂通过对其被包封的聚合物基质的表面开放的孔释放。 该装置可以皮下给予需要用多巴胺激动剂连续治疗的个体。