公开(公告)号：US20050256168A1

公开(公告)日：2005-11-17

申请号：US11116088

申请日：2005-04-27

申请人： Timothy Block ,  Anand Mehta ,  Xuanyong Lu ,  Raymond Dwek

发明人： Timothy Block ,  Anand Mehta ,  Xuanyong Lu ,  Raymond Dwek

IPC分类号： A61K31/4015 ,  A61K31/445

CPC分类号： A61K31/4015 ,  A61K31/445

摘要： Compositions and methods of treatment of interferon-responsive disorders are provided wherein the methods, for example, comprise orally administering a composition which comprises a therapeutically effective amount of at least one alkylated imino sugar having an alkylated side chain, and a pharmaceutically acceptable carrier.

摘要翻译： 提供了治疗干扰素反应性病症的组合物和方法，其中所述方法例如包括口服施用包含治疗有效量的至少一种具有烷基化侧链的烷基化亚氨基糖的组合物和药学上可接受的载体。

公开(公告)号：US20050053625A1

公开(公告)日：2005-03-10

申请号：US10494377

申请日：2002-10-30

申请人： Timothy Block ,  Anand Mehta ,  Raymond Dwek

发明人： Timothy Block ,  Anand Mehta ,  Raymond Dwek

IPC分类号： A61K31/445 ,  A61K38/16 ,  A61K39/29

CPC分类号： A61K31/445 ,  A61K38/162 ,  A61K39/12 ,  A61K39/29 ,  A61K39/292 ,  A61K2039/5258 ,  C12N2730/10134 ,  A61K2300/00

摘要： The present invention relates to the treatment of viral infections, particularly HBV and HCV infections, with a combination comprising a vaccine against a virus antigen and compounds that inhibit glucosidase activity in the host cell.

摘要翻译： 本发明涉及包含针对病毒抗原的疫苗和抑制宿主细胞中的葡糖苷酶活性的化合物的组合的病毒感染，特别是HBV和HCV感染的治疗。

公开(公告)号：US20050267153A1

公开(公告)日：2005-12-01

申请号：US10910197

申请日：2004-08-03

申请人： Richard Mueller ,  Martin Bryant ,  Richard Partis ,  Gary Jacob ,  Timothy Block ,  Raymond Dwek

发明人： Richard Mueller ,  Martin Bryant ,  Richard Partis ,  Gary Jacob ,  Timothy Block ,  Raymond Dwek

IPC分类号： A61K31/445 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7064 ,  A61K31/7068 ,  A61K45/06 ,  A61P1/16 ,  A61P31/20 ,  C07D211/46 ,  C07H19/10

CPC分类号： C07D211/46 ,  A61K31/445 ,  A61K45/06

摘要： Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immuno-stimulating agents.

摘要翻译： 提供用于治疗哺乳动物，特别是人类的肝炎病毒感染的方法和组合物。 方法包括（1）单独或与核苷抗病毒剂，核苷酸抗病毒剂，其混合物或免疫调节/免疫刺激剂单独或组合施用N-取代的-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物，或 （2）单独或与核苷抗病毒剂，核苷酸抗病毒剂或其混合物以及免疫调节/免疫刺激剂组合施用N-取代-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物。

公开(公告)号：US20060106065A1

公开(公告)日：2006-05-18

申请号：US11300463

申请日：2005-12-15

申请人： Gary Jacob ,  Timothy Block ,  Raymond Dwek

发明人： Gary Jacob ,  Timothy Block ,  Raymond Dwek

IPC分类号： A61K31/445

CPC分类号： C07D211/46 ,  A61K31/445 ,  A61K45/06

摘要： Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immunostimulating agents.

摘要翻译： 提供用于治疗哺乳动物，特别是人类的肝炎病毒感染的方法和组合物。 方法包括（1）与核苷抗病毒剂，核苷酸抗病毒剂，其混合物或免疫调节/免疫刺激剂组合施用N-取代的-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物，或（2 ）与核苷抗病毒剂，核苷酸抗病毒剂或其混合物以及免疫调节/免疫刺激剂组合施用N-取代的-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物。

公开(公告)号：US20060094671A1

公开(公告)日：2006-05-04

申请号：US11300464

申请日：2005-12-15

申请人： Gary Jacob ,  Timothy Block ,  Raymond Dwek

发明人： Gary Jacob ,  Timothy Block ,  Raymond Dwek

IPC分类号： A61K31/7076 ,  A61K31/7072 ,  A61K31/7056 ,  A61K31/445

CPC分类号： C07D211/46 ,  A61K31/445 ,  A61K45/06

摘要： Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immunostimulating agents.

公开(公告)号：US08957106B2

公开(公告)日：2015-02-17

申请号：US12081661

申请日：2008-04-18

申请人： Raymond Dwek ,  Wanda Buzgariu ,  Anca Hirtopeanu ,  Robert Moriarty ,  Gabriela Negroiu ,  Norica Nichita ,  Livia Zdrentu ,  Nicole Zitzmann

发明人： Raymond Dwek ,  Wanda Buzgariu ,  Anca Hirtopeanu ,  Robert Moriarty ,  Gabriela Negroiu ,  Norica Nichita ,  Livia Zdrentu ,  Nicole Zitzmann

IPC分类号： A01N43/36 ,  A61K31/40 ,  A01N31/00 ,  A61K31/045 ,  C12N5/071 ,  A61K31/7004

CPC分类号： A61K31/40 ,  A61K31/7004

摘要： A proliferation of cells can be reduced by contacting the cells with a compound having formula (I) where R and R′ are each alkyl groups, R″ is hydrogen or an alkyl group and X3, X4 and X5 are each independently selected from the group consisting of hydrogen, benzyl, t-butyldimethylsiloxy radical and triphenylmethyl. Accordingly, compounds of formula (I) can be used for treatment of tumors including melanoma. Also a secretion of a matrix metalloproteinase (MMP) enzyme by cells can be reduced by contacting the cells with the compound having formula (I). Accordingly, compounds of formula (I) can be used for treatment physiological conditions associated with an elevated MMP level, such as tumors.

摘要翻译： 通过使细胞与具有式（I）的化合物（其中R和R'各自为烷基，R“是氢或烷基）并且X 3，X 4和X 5各自独立地选自基团 由氢，苄基，叔丁基二甲基甲硅烷氧基和三苯基甲基组成。 因此，式（I）化合物可用于治疗包括黑素瘤的肿瘤。 通过使细胞与式（I）的化合物接触，也可以通过细胞分泌基质金属蛋白酶（MMP）酶。 因此，式（I）化合物可用于与升高的MMP水平例如肿瘤相关的治疗生理条件。

公开(公告)号：US20110143351A1

公开(公告)日：2011-06-16

申请号：US12452720

申请日：2008-07-21

申请人： Pauline Rudd ,  James Arnold ,  Radka Saldova ,  Louise Royle ,  Umi Marshida Abd Hamid ,  Raymond Dwek ,  Rosa Peracaula ,  Rafael De Llorens

发明人： Pauline Rudd ,  James Arnold ,  Radka Saldova ,  Louise Royle ,  Umi Marshida Abd Hamid ,  Raymond Dwek ,  Rosa Peracaula ,  Rafael De Llorens

IPC分类号： G01N33/53 ,  G01N33/559 ,  G01N27/447 ,  H01J49/26

CPC分类号： G01N33/5308 ,  G01N33/57469 ,  G01N2400/10 ,  G01N2800/52

摘要： The present invention provides novel biomarkers for use in the diagnosis and prognosis of cancerous and malignant conditions and further of diseases which are mediated by a proinflammatory immune response. The biomarkers are glycoproteins, the levels of expression of which have been correlated by the inventors to correspond to particular disease conditions. The invention further extends to methods for use in monitoring the response to therapy of a treatment for use in the treatment of a cancerous condition or proinflammatory disease.

摘要翻译： 本发明提供了用于诊断和预后的癌症和恶性疾病以及由促炎免疫应答介导的疾病的新型生物标志物。 生物标志物是糖蛋白，其表达水平已被发明人相关以对应于特定的疾病状况。 本发明进一步延伸到用于监测用于治疗癌症或炎性疾病的治疗的应答​​的方法。

公开(公告)号：US20060269979A1

公开(公告)日：2006-11-30

申请号：US11411231

申请日：2006-04-26

申请人： Raymond Dwek ,  Louise Royle ,  Pauline Rudd

发明人： Raymond Dwek ,  Louise Royle ,  Pauline Rudd

IPC分类号： C12Q1/37 ,  G01N33/00

CPC分类号： G01N33/6842 ,  G01N33/564 ,  G01N33/6848 ,  G01N2400/00 ,  G01N2800/102 ,  G01N2800/24

摘要： One can identify and quantify one or more glycosylation markers of an autoimmune disease such as rheumatoid arthritis by utilizing quantitative HPLC analysis of glycans which have been released from unpurified glycoproteins. The unpurified glycoproteins can be total glycoproteins or a selection of the total glycoproteins. The identified glycosylation marker can be utilized for monitoring and/or diagnosing the autoimmune disease.

摘要翻译： 通过利用已经从未纯化的糖蛋白释放的聚糖的定量HPLC分析，可以鉴定和定量自身免疫性疾病如类风湿性关节炎的一种或多种糖基化标记物。 未纯化的糖蛋白可以是总糖蛋白或总糖蛋白的选择。 鉴定的糖基化标记可用于监测和/或诊断自身免疫性疾病。

公开(公告)号：US20110136868A1

公开(公告)日：2011-06-09

申请号：US12847038

申请日：2010-07-30

申请人： Anastasios Karadimitris ,  Nikki Horwood ,  Amin Rahemtulla ,  Anne Dell ,  Terry Butters ,  Raymond Dwek

发明人： Anastasios Karadimitris ,  Nikki Horwood ,  Amin Rahemtulla ,  Anne Dell ,  Terry Butters ,  Raymond Dwek

IPC分类号： A61K31/445 ,  A61P35/00 ,  A61P19/00

CPC分类号： A61K31/445 ,  A61K31/00

摘要： Agents, which are both ceramide glucosyltransferase inhibitors and glucosidase inhibitors, may inhibit osteoclastogenesis and/or reduce osteoclast activation and, therefore, may be useful for osteolytic activity and bone loss in subjects with conditions, such as multiple myeloma.

摘要翻译： 二者均为神经酰胺葡糖基转移酶抑制剂和葡糖苷酶抑制剂，可以抑制破骨细胞发生和/或减少破骨细胞活化，并因此可用于具有条件如多发性骨髓瘤的受试者的溶骨活性和骨丢失。

公开(公告)号：US20100266678A1

公开(公告)日：2010-10-21

申请号：US12732630

申请日：2010-03-26

申请人： Stephanie Pollock ,  Raymond Dwek ,  Nicole Zitzmann

发明人： Stephanie Pollock ,  Raymond Dwek ,  Nicole Zitzmann

IPC分类号： A61K9/127 ,  A61P31/12

CPC分类号： A61K9/127 ,  A61K9/0019 ,  A61K9/1271 ,  A61K31/683 ,  A61K31/685 ,  A61K47/6911 ,  Y02A50/385

摘要： Provided are methods of reducing cellular cholesterol levels using lipid particles that are capable of cellular entry. Such lipid particles may be used for treating or preventing a disease or condition that is caused by or associated with an increased cellular cholesterol level and for treating or preventing a disease or condition, that is caused by or associated with a virus, that relies on cellular cholesterol for its replication.

摘要翻译： 提供使用能够进入细胞的脂质颗粒降低细胞胆固醇水平的方法。 这种脂质颗粒可用于治疗或预防由细胞胆固醇水平升高引起或与细胞胆固醇水平升高相关的疾病或病症，并用于治疗或预防依赖于细胞因子的病毒引起或与之相关的疾病或病症 胆固醇用于其复制。