公开(公告)号：US4017578A

公开(公告)日：1977-04-12

申请号：US586459

申请日：1975-06-12

Applicant: Thomas R. Jarboe ,  William R. Baker

Inventor： Thomas R. Jarboe ,  William R. Baker

IPC: F25J1/00 ,  H05H1/22 ,  B02C18/02 ,  G21B1/02

CPC classification number: F25J1/0221 ,  F25J1/001 ,  F25J1/0276 ,  G21B1/19 ,  F25J2205/20 ,  F25J2210/42 ,  F25J2290/42 ,  Y02E30/16 ,  Y10S376/916

Abstract: An apparatus and method for producing deuterium targets or pellets of 25.mu. to 75.mu. diameter. The pellets are sliced from a continuously spun solid deuterium thread at a rate of up to 10 pellets/second. The pellets after being sliced from the continuous thread of deuterium are collimated and directed to a point of use, such as a laser activated combustion or explosion chamber wherein the pellets are imploded by laser energy or laser produced target plasmas for neutral beam injection.

Abstract translation: 一种制造直径25〜75μm的氘靶或丸粒的装置及方法。 将颗粒从持续纺丝的固体氘丝以最多10个丸粒/秒的速率切片。 从连续的氘丝线切片后的颗粒被准直并且被引导到使用点，例如激光活化燃烧或爆炸室，其中颗粒被激光能量或激光产生的靶等离子体用于中性束注入。

公开(公告)号：US20130012504A1

公开(公告)日：2013-01-10

申请号：US13619636

申请日：2012-09-14

Applicant: William R. Baker ,  Shaopei Cai ,  Joshua Aaron Kaplan ,  Musong Kim ,  Jennifer Alissa Loyer-Drew ,  Stephane Perreault ,  Gary Phillips ,  Lafe J. Purvis, II ,  Marcin Stasiak ,  Kirk L. Stevens ,  Josh Van Veldhuizen

Inventor： William R. Baker ,  Shaopei Cai ,  Joshua Aaron Kaplan ,  Musong Kim ,  Jennifer Alissa Loyer-Drew ,  Stephane Perreault ,  Gary Phillips ,  Lafe J. Purvis, II ,  Marcin Stasiak ,  Kirk L. Stevens ,  Josh Van Veldhuizen

IPC: C07D215/54 ,  C07D401/14 ,  A61K31/496 ,  C07D413/12 ,  A61K31/538 ,  A61K31/4706 ,  C07D409/14 ,  A61P29/00 ,  A61P31/00 ,  A61P37/08 ,  A61P11/00 ,  A61P11/08 ,  A61P11/06 ,  A61P11/10 ,  A61P11/02 ,  A61K31/4709

CPC classification number: C07D215/54 ,  C07D401/12 ,  C07D409/14 ,  C07D413/12

Abstract: Provided are compounds of Formula I: R1 and R2 together with the phenyl to which they are bound may form a bicyclic, fused heterocyclic ring, and all other variables are as defined herein, as well as their use in treating pulmonary inflammation or bronchoconstriction and compositions comprising and processes for preparing the same.

Abstract translation: 提供式I化合物：R 1和R 2与它们所连接的苯基一起可以形成双环稠合杂环，并且所有其它变量如本文所定义，以及它们在治疗肺部炎症或支气管收缩和组合物中的用途 包括及其制备方法。

公开(公告)号：US20110275622A1

公开(公告)日：2011-11-10

申请号：US13103577

申请日：2011-05-09

Applicant: William R. Baker ,  Shaopei Cai ,  Joshua Aaron Kaplan ,  Musong Kim ,  Jennifer Alissa Loyer-Drew ,  Stephane Perreault ,  Gary Phillips ,  Lafe J. Purvis, II ,  Marcin Stasiak ,  Kirk L. Stevens ,  Josh Van Veldhuizen

Inventor： William R. Baker ,  Shaopei Cai ,  Joshua Aaron Kaplan ,  Musong Kim ,  Jennifer Alissa Loyer-Drew ,  Stephane Perreault ,  Gary Phillips ,  Lafe J. Purvis, II ,  Marcin Stasiak ,  Kirk L. Stevens ,  Josh Van Veldhuizen

IPC: A61K31/4709 ,  C07D401/14 ,  C07D413/12 ,  A61K31/496 ,  A61K31/538 ,  A61P29/00 ,  A61K31/475 ,  A61P11/00 ,  A61P11/06 ,  A61P11/08 ,  A61P3/00 ,  C07D215/54 ,  A61K31/4706

CPC classification number: C07D215/54 ,  C07D401/12 ,  C07D409/14 ,  C07D413/12

Abstract: Provided are compounds of Formula I: wherein X is: R1 and R2 together with the phenyl to which they are bound may form a bicyclic, fused heterocyclic ring, and all other variables are as defined herein, as well as their use in treating pulmonary inflammation or bronchoconstriction and compositions comprising and processes for preparing the same.

Abstract translation: 提供式I的化合物：其中X是：R 1和R 2与它们所连接的苯基一起可以形成双环稠合杂环，并且所有其它变量如本文所定义，以及它们在治疗肺部炎症中的用途 或支气管收缩剂及其组合物及其制备方法。

公开(公告)号：US20090318396A1

公开(公告)日：2009-12-24

申请号：US12481364

申请日：2009-06-09

Applicant: William R. Baker ,  Musong Kim ,  Alexander Rudolph ,  Marcin Stasiak ,  Josh Van Veldhuizen

Inventor： William R. Baker ,  Musong Kim ,  Alexander Rudolph ,  Marcin Stasiak ,  Josh Van Veldhuizen

IPC: A61K31/58 ,  C07J71/00 ,  A61P11/00

CPC classification number: C07J71/0031 ,  C07J51/00

Abstract: New chemical entities which comprise corticosteroids and phosphorylated β-agonists for use in therapy and compositions comprising and processes for preparing the same.

Abstract translation: 包含用于治疗的皮质类固醇和磷酸化β-激动剂的新化学实体及其制备方法及其制备方法。

公开(公告)号：US5541320A

公开(公告)日：1996-07-30

申请号：US413659

申请日：1995-03-30

Applicant: William R. Baker ,  John K. Pratt ,  Daniel W. Norbeck ,  Chen Zhao

Inventor： William R. Baker ,  John K. Pratt ,  Daniel W. Norbeck ,  Chen Zhao

IPC: C07D211/76 ,  C07D211/86 ,  C07D213/69 ,  C07D213/26

CPC classification number: C07D213/69 ,  C07D211/76 ,  C07D211/86

Abstract: A process is disclosed for the preparation of a substituted diaminoalcohol of the formula: ##STR1##

公开(公告)号：US5244910A

公开(公告)日：1993-09-14

申请号：US736364

申请日：1991-07-31

Applicant: William R. Baker ,  Steven A. Boyd ,  Anthony K. L. Fung ,  Herman H. Stein ,  Jon F. Denissen ,  Charles W. Hutchins

Inventor： William R. Baker ,  Steven A. Boyd ,  Anthony K. L. Fung ,  Herman H. Stein ,  Jon F. Denissen ,  Charles W. Hutchins

IPC: A61K31/495 ,  A61K31/535 ,  A61K38/55 ,  C07D211/46 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D451/06 ,  C07D451/14

CPC classification number: C07D451/06 ,  A61K31/495 ,  A61K31/535 ,  A61K38/553 ,  C07D211/46 ,  C07D401/12 ,  C07D405/12 ,  C07D413/10 ,  C07D451/14

Abstract: A renin inhibiting compound of the formula: ##STR1## wherein X is O NH or S and G is a mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof; with the proviso that the compound is not N-(3-(4-Morpholino)propyl)-5(S)-(2(S)-(1(S)-(4-(methoxymethoxy)piperidin-1-yl)carbonyl-2- phenyl)ethoxyhexanamido)-6-cyclohexyl-4(S)-hydroxy-2(S)-isopropylhexanamide.

Abstract translation: 下式的肾素抑制化合物：其中X是O NH或S，G是血管紧张素原的Leu-Val切割位点的模拟物; 或其药学上可接受的盐，酯或前药; 条件是该化合物不是N-（3-（4-吗啉代）丙基）-5（S） - （2（S） - （1（S） - （4-（甲氧基甲氧基）哌啶-1-基 ）羰基-2-苯基）乙氧基己酰氨基）-6-环己基-4（S） - 羟基-2（S） - 异丙基己酰胺。

公开(公告)号：US5164388A

公开(公告)日：1992-11-17

申请号：US678266

申请日：1991-04-18

Applicant: Biswanath De ,  Thomas N. Zydowsky ,  William R. Baker ,  Joseph F. Dellaria ,  Saul H. Rosenberg ,  Hwan S. Jae

Inventor： Biswanath De ,  Thomas N. Zydowsky ,  William R. Baker ,  Joseph F. Dellaria ,  Saul H. Rosenberg ,  Hwan S. Jae

IPC: A61K38/00 ,  C07D211/14 ,  C07D211/76 ,  C07D213/74 ,  C07D233/54 ,  C07D239/42 ,  C07D241/04 ,  C07D241/08 ,  C07D243/08 ,  C07D263/10 ,  C07D263/22 ,  C07D295/15 ,  C07D403/06 ,  C07D413/04 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07K5/078

CPC classification number: C07D233/64 ,  C07D211/14 ,  C07D211/76 ,  C07D213/74 ,  C07D239/42 ,  C07D241/04 ,  C07D241/08 ,  C07D243/08 ,  C07D263/10 ,  C07D263/22 ,  C07D295/15 ,  C07D403/06 ,  C07D413/04 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07K5/06139 ,  A61K38/00 ,  C07C2101/14

Abstract: A renin inhibiting compound of the formula ##STR1## wherein X is N, O or CH; R.sub.1 is absent or a functional group; A and L are independently selected from absent, C.dbd.O, SO.sub.2 and CH.sub.2 ; D is C.dbd.O, SO.sub.2 or CH.sub.2 ; Y is N or CH; R.sub.2 is hydrogen, loweralkyl or substituted alkyl; Z is a functional group; R.sub.3 is loweralkyl or substituted alkyl; n is 0 or 1; and T is a mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof.

Abstract translation: 其中X是N，O或CH的式（Ⅰ）的肾素抑制化合物; R1不存在或官能团; A和L独立地选自C = O，SO 2和CH 2; D是C = O，SO 2或CH 2; Y为N或CH; R2是氢，低级烷基或取代的烷基; Z是功能组; R3是低级烷基或取代的烷基; n为0或1; T是模拟血管紧张素原的Leu-Val切割位点; 或其药学上可接受的盐，酯或前药。

公开(公告)号：US4836726A

公开(公告)日：1989-06-06

申请号：US213188

申请日：1988-06-29

Applicant: James C. Robertson ,  William R. Baker

Inventor： James C. Robertson ,  William R. Baker

IPC: B60P3/077 ,  B61D45/00

CPC classification number: B61D45/004 ,  B60P3/077 ,  B61D45/001

Abstract: A chock block for a vehicle transported on a deck to secure the vehicle against longitudinal movement; the chock block having a first member and a longitudinal second member lateral to the first member; the first member nesting with a track on the deck and removable from such nesting by upward displacement; the second member extending along and terminating beyond the tread face of a vehicle tire; a pin on the chock block for removably securing the first member to the track to prevent the chock block from horizontal and upward movement; the second member having a longitudinal center when viewed from the top; the chock block being essentially symmetrical about the second member longitudinal center; and the pin having a handle observable and manually operable from both sides of the second member longitudinal center to withdraw the pin forward end from a track hole to remove the chock block from the track and to help position the pin forward end in a track hole.

Abstract translation: 在甲板上运输的车辆的轴承座，用于固定车辆纵向运动; 所述阻塞块具有第一构件和横向于所述第一构件的纵向第二构件; 第一个成员与甲板上的轨道嵌套，并通过向上移位而从这种嵌套中移除; 所述第二构件沿着车辆轮胎的胎面延伸并且终止于车辆轮胎的胎面; 轴承座上的销子，用于可拆卸地将第一构件固定到轨道上，以防止阻塞块水平和向上移动; 所述第二构件从所述顶部观察时具有纵向中心; 所述阻塞块基本上关于所述第二构件纵向中心对称; 并且销具有可观察并且可从第二构件纵向中心的两侧手动操作的手柄，以将销的前端从轨道孔撤回，以将轨道块从轨道移除并帮助将销前端定位在轨道孔中。

公开(公告)号：US08450490B2

公开(公告)日：2013-05-28

申请号：US13619792

申请日：2012-09-14

Applicant: William R. Baker ,  Shaopei Cai ,  Joshua Aaron Kaplan ,  Musong Kim ,  Gary Phillips ,  Lafe J. Purvis, II ,  Marcin Stasiak ,  Kirk L. Stevens ,  Josh Van Veldhuizen

Inventor： William R. Baker ,  Shaopei Cai ,  Joshua Aaron Kaplan ,  Musong Kim ,  Gary Phillips ,  Lafe J. Purvis, II ,  Marcin Stasiak ,  Kirk L. Stevens ,  Josh Van Veldhuizen

IPC: C07D513/02

CPC classification number: C07D471/04

Abstract: This invention provides compounds of the formula: wherein X is wherein R1 and R2 together with the phenyl to which they are bound may form a bicyclic, fused heterocyclic ring and all other variables are as defined herein, their use in pulmonary inflammation or bronchoconstriction therapy and compositions comprising and processes for preparing the same are provided.

Abstract translation: 本发明提供下式的化合物：其中X是其中R 1和R 2与它们所连接的苯基一起可以形成双环稠合杂环，所有其它变量如本文所定义，它们在肺部炎症或支气管收缩治疗中的用途，以及 提供了组合物及其制备方法。

公开(公告)号：US20090004279A1

公开(公告)日：2009-01-01

申请号：US12208247

申请日：2008-09-10

Applicant: Thomas Hofmann ,  Alan Bruce Montgomery ,  Kevin Stapleton ,  William R. Baker

Inventor： Thomas Hofmann ,  Alan Bruce Montgomery ,  Kevin Stapleton ,  William R. Baker

IPC: A61K9/14 ,  A61K31/167 ,  A61K31/545 ,  A61K38/12 ,  A61K31/7036 ,  A61K31/403 ,  A61K31/431 ,  A61K38/00 ,  A61K31/397 ,  A61K31/665 ,  A61K31/395 ,  A61K31/547 ,  A61K31/444 ,  A61K38/06 ,  A61K31/155 ,  A61K31/44 ,  A61K31/277 ,  A61K31/341 ,  A61P43/00 ,  A61K31/727 ,  A61K31/573 ,  A61K31/50 ,  A61K31/4162 ,  A61K31/343 ,  A61K31/335

CPC classification number: A61K9/0075 ,  A61K9/0078 ,  A61K9/008

Abstract: A method for improvement of tolerance for therapeutically effective agents delivered by inhalation comprising a pretreatment of a patient with a nebulized lidocaine or a lidocaine-like compound administered immediately or up to about thirty minutes before administration of the primary therapeutically effective agent. The pretreatment of the patient with the nebulized lidocaine or a lidocaine-like compound improves airway tolerance and deposition of the agent in the lungs and makes such deposition more safe, efficacious, controllable and predictable. The method of the invention is especially useful for enhancement of deposition of immunosuppressive agents in the lung(s) of transplant patients, improved tolerance of the drugs by reducing cough, and improving pulmonary drug deposition.

Abstract translation: 一种用于改善通过吸入递送的治疗有效药物的耐受性的方法，其包括在给予主要治疗有效药剂之前立即施用或至多约30分钟施用雾化的利多卡因或利多卡因样化合物的患者的预处理。 患有雾化利多卡因或利多卡因样化合物的患者的预处理改善了气道耐受性并且将药物沉积在肺中，并使得沉积更安全，有效，可控和可预测。 本发明的方法对于增强免疫抑制剂在移植患者的肺中的沉积特别有用，通过减少咳嗽改善药物的耐受性并改善肺部药物沉积。