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公开(公告)号：US06242442B1
公开(公告)日：2001-06-05
申请号：US09601634
申请日：2000-08-04
IPC分类号： A67K31535
CPC分类号： A61K31/542 , A61K31/498 , A61K31/54 , Y10S514/912 , Y10S514/913 , A61K2300/00 , A61K31/495
摘要： Methods and compositions for treating ocular conditions which find their etiology in compromised ocular blood flow with brinzolamide and brimonidine are disclosed.
摘要翻译： 公开了用于治疗眼睛病症的方法和组合物，其用于使用布林唑胺和溴莫尼定在眼损伤的血流中发现其病因。
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公开(公告)号：US06316441B1
公开(公告)日：2001-11-13
申请号：US09832998
申请日：2001-04-11
IPC分类号： A61K31535
CPC分类号： A61K31/542 , A61K31/498 , A61K31/54 , Y10S514/912 , Y10S514/913 , A61K2300/00 , A61K31/495
摘要： Methods and compositions for treating ocular conditions which find their etiology in compromised ocular blood flow with brinzolamide and brimonidine are disclosed.
摘要翻译： 公开了用于治疗眼睛病症的方法和组合物，其用于使用布林唑胺和溴莫尼定在眼损伤的血流中发现其病因。
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公开(公告)号：US06344478B2
公开(公告)日：2002-02-05
申请号：US09777409
申请日：2001-02-06
IPC分类号： A61K31557
CPC分类号： C07C405/00 , A61K9/0048 , A61K31/557 , A61K31/5575 , A61K31/558 , A61K45/06 , C07C405/0025 , Y10S514/912 , Y10S514/913 , A61K2300/00
摘要： Disclosed is the use of cloprostenol and fluprostenol analogues in combination with carbonic anhydrase inhibitors for the treatment of glaucoma and ocular hypertension and ophthalmic compositions therefor.
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公开(公告)号：US5932572A
公开(公告)日：1999-08-03
申请号：US920314
申请日：1997-08-27
IPC分类号： A61K31/38 , A61K31/425 , A61K31/54 , A61K31/535
CPC分类号： A61K31/38 , A61K31/425 , A61K31/54 , Y10S514/913
摘要： Ophthalmic pharmaceutical compositions useful in controlling elevated intraocular pressure associated with glaucoma and ocular hypertension are described. The compositions comprise a combination of a beta-blocker and a carbonic anhydrase inhibitor to reduce the production of aqueous humor, preferably formulated as a suspension having a pH between about 6.8 and about 7.8. These compositions may additionally contain a mucomimetic anionic polymer and/or a finely-divided drug carrier substrate to provide sustained release. A method of controlling elevated intraocular pressure with these compositions is also described.
摘要翻译： 描述了可用于控制与青光眼和高眼压症相关的升高的眼内压的眼用药物组合物。 组合物包含β-阻断剂和碳酸酐酶抑制剂的组合以减少房水的产生，优选配制为pH在约6.8至约7.8之间的悬浮液。 这些组合物可另外含有模拟阴离子聚合物和/或细碎药物载体底物以提供持续释放。 还描述了使用这些组合物来控制眼内压升高的方法。
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5.发明授权Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders 有权用于治疗眼睛和CNS疾病的5-羟色胺能5HT7受体化合物公开(公告)号：US07285553B2
公开(公告)日：2007-10-23
申请号：US11265030
申请日：2005-11-02
IPC分类号： C07D403/00 , C07D401/00 , C07D241/04 , A61K31/495
CPC分类号： C07D295/088 , C07D209/08 , C07D217/04 , C07D235/26 , C07D295/13 , C07D401/12 , C07D513/04
摘要： Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for treating sleep disorders, depression, and other psychiatric disorders, such as, schizophrenia, anxiety, obsessive compulsive disorder, circadian rhythm disorders, and centrally and peripherally mediated hypertension. Compositions and methods for their use are also disclosed.
摘要翻译： 公开了可用于降低IOP，改善视神经头和视网膜的血流量，提供神经保护和治疗视网膜疾病的具有5HT 7受体亲和力（其中一些是新颖的）的化合物。 化合物还可用于治疗睡眠障碍，抑郁症和其他精神病学障碍，例如精神分裂症，焦虑症，强迫症，昼夜节律紊乱以及中枢和外周介导的高血压。 还公开了其使用的组合物和方法。
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公开(公告)号：US5585377A
公开(公告)日：1996-12-17
申请号：US362716
申请日：1994-12-23
申请人： Thomas R. Dean , Jesse A. May , Hwang-Hsing Chen
发明人： Thomas R. Dean , Jesse A. May , Hwang-Hsing Chen
IPC分类号： C07D333/34 , C07D333/38 , C07D409/04 , C07D495/04 , C07D513/04 , A61K31/54
CPC分类号： C07D513/04
摘要： Sulfonamides and pharmaceutical compositions containing the compounds useful in controlling intraocular pressure are disclosed. Methods for controlling intraocular pressure through administration of the compositions are also disclosed.
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公开(公告)号：US4844727A
公开(公告)日：1989-07-04
申请号：US121072
申请日：1987-11-16
申请人： Thomas R. Dean
发明人： Thomas R. Dean
IPC分类号： A01N47/36 , C07D521/00
CPC分类号： C07D521/00 , A01N47/36
摘要： Sulfonylureas with uniquely substituted heterocycles demonstrate activity as agricultural chemicals.
摘要翻译： 具有独特取代杂环的磺酰脲显示出作为农药的活性。
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公开(公告)号：US07060704B2
公开(公告)日：2006-06-13
申请号：US11100918
申请日：2005-04-07
IPC分类号： C07D241/02 , C07D279/02 , C07D401/12 , A61K31/443 , A61K31/4965
CPC分类号： C07D295/088 , C07D209/08 , C07D217/04 , C07D235/26 , C07D295/13 , C07D401/12 , C07D513/04
摘要： Compounds with 5HT7 receptor affinity (some of which are novel) useful for lowering IOP, improving blood flow to the optic nerve head and the retina, providing neuroprotection, and treating retinal diseases are disclosed. The Compounds are also useful for treating sleep disorders, depression, and other psychiatric disorders, such as, schizophrenia, anxiety, obsessive compulsive disorder, circadian rhythm disorders, and centrally and peripherally mediated hypertension. Compositions and methods for their use are also disclosed.
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公开(公告)号：US5038704A
公开(公告)日：1991-08-13
申请号：US326112
申请日：1989-03-20
CPC分类号： B61L23/06 , G09F17/00 , G09F2017/005
摘要： The present invention provides a portable, temporary railroad signaling device which may be tenaciously secured onto a railroad rail and its use. The device includes an adjustable and fixed clamping mechanism for clasping onto a railroad rail placed therewithin, which mechanism when tightly drawn together mechanically biases and wedges the rail therebetween. The device advantageously includes a collapsible arm to mount and support a signaling unit thereupon an internal housing for stowing a signaling unit therewithin and a lock for locking the clamped device onto the rail to protect the device against unauthorized tampering.
摘要翻译： 本发明提供一种便携式的临时铁路信号装置，其可以牢固地固定在铁路轨道上及其用途上。 该装置包括可调和固定的夹紧机构，用于紧固在放置在其上的铁路轨道上，当紧密拉在一起时机构偏置并楔入轨道之间的机构。 该装置有利地包括可折叠臂，用于将信号单元安装并支撑在其上的用于收存信号单元的内部壳体和用于将夹持的装置锁定在轨道上的锁，以保护装置免受未经授权的篡改。
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公开(公告)号：US4900353A
公开(公告)日：1990-02-13
申请号：US242114
申请日：1988-09-09
IPC分类号： A01N47/36 , C07D521/00 , A01N43/66 , A01N43/68 , C07D401/12 , C07D401/14
CPC分类号： C07D521/00 , A01N47/36
摘要： This invention relates to pyridine N-oxide sulfonylurea herbicides, agriculturally suitable compositions containing them and their method-of-use as preemergent and/or postemergent herbicides or plant growth regulants.
摘要翻译： 本发明涉及吡啶N-氧化物磺酰脲类除草剂，含有它们的农业合适的组合物及其作为前期和/或芽后除草剂或植物生长调节剂的使用方法。
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