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1.发明申请公开(公告)号：US20130199998A1
公开(公告)日：2013-08-08
申请号：US13565733
申请日：2012-08-02
申请人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
发明人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
IPC分类号： A61M1/16
CPC分类号： A61M1/3482 , A61M1/1696 , A61M2202/0021 , A61M2202/0413
摘要： Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.
摘要翻译： 公开了用于执行肾脏替代疗法的系统和方法，其具有或使用透析器，控制组件，吸附剂盒和流体储存器，其被配置为适于被需要治疗的个体穿戴或携带的重量和尺寸。 用于执行肾脏替代治疗的系统具有受控的依从性透析电路，其中控制泵控制流体穿过透析膜的双向运动。 透析电路和用于循环血液的体外循环通过透析膜流体连通。 在体外循环和透析回路之间移动的流体通量由控制泵运行的速率改变，从而可以控制超滤速率和对流间隙。 该系统提供对吸附剂盒的入口和出口导电性的监测，以提供量化或监测吸附剂盒去除尿素的设施。
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公开(公告)号：US10695481B2
公开(公告)日：2020-06-30
申请号：US13565733
申请日：2012-08-02
申请人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
发明人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
摘要： Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.
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3.发明申请POLYSTYRENE SULFONATE RESIN FOR USE WITH A HEMODIALYSIS SYSTEM HAVING A CONTROLLED COMPLIANCE DIALYSIS CIRCUIT 审中-公开聚苯乙烯磺酸酯树脂与具有控制的合规性透析电路的血液透析系统一起使用公开(公告)号：US20130256227A1
公开(公告)日：2013-10-03
申请号：US13612701
申请日：2012-09-12
申请人： Thomas D. Kelly , SuPing Lyu
发明人： Thomas D. Kelly , SuPing Lyu
IPC分类号： A61M1/36
CPC分类号： A61M1/3621 , A61M1/1696
摘要： Sorbent cartridges having a polystyrene sulfonate resin saturated with calcium ions for the performance of kidney replacement therapy are disclosed. Systems and methods having or using a sorbent cartridge, a dialyzer, control components, a cartridge having a polystyrene sulfonate resin, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. A system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to quantify or monitor the removal of urea by the sorbent cartridge.
摘要翻译： 公开了具有用钙离子饱和的聚苯乙烯磺酸盐树脂进行肾脏替代疗法的吸收性药筒。 公开了具有或使用吸附剂药筒，透析器，控制组件，具有聚苯乙烯磺酸酯树脂的药筒和被配置为具有适于由需要治疗的个体佩戴或携带的重量和尺寸的流体储存器的系统和方法。 用于执行肾脏替代治疗的系统具有受控的依从性透析电路，其中控制泵控制流体穿过透析膜的双向运动。 该系统提供对吸附剂盒的入口和出口导电性的监测，以量化或监测吸附剂盒的尿素去除。
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公开(公告)号：US10857277B2
公开(公告)日：2020-12-08
申请号：US13586824
申请日：2012-08-15
申请人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
发明人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
摘要： Apparatuses, systems, and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. A first sorbent cartridge is provided for use in a portable treatment module having activated carbon and zirconium oxide. The system also provides for the monitoring of an inlet and outlet conductivity of a sorbent cartridge containing urease to provide a facility to quantify or monitor the removal of urea by a detachable urea removal module.
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公开(公告)号：US09707330B2
公开(公告)日：2017-07-18
申请号：US14240129
申请日：2012-08-22
申请人： Thomas D. Kelly , SuPing Lyu
发明人： Thomas D. Kelly , SuPing Lyu
CPC分类号： A61M1/1696 , A61M1/16 , A61M1/3609 , A61M2205/15 , A61M2205/3313 , A61M2205/3317 , A61M2205/50 , A61M2205/75 , A61M2209/082 , A61M2230/65 , B01D15/00 , B01D15/02 , B01D2313/44 , B01J20/0211 , B01J20/0292 , B01J20/20 , B01J20/24 , B01J2220/62
摘要： Disclosed are systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, a sorbent cartridge with at least two separate flow paths, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.
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公开(公告)号：US20140326671A1
公开(公告)日：2014-11-06
申请号：US14240129
申请日：2012-08-22
申请人： Thomas D. Kelly , SuPing Lyu
发明人： Thomas D. Kelly , SuPing Lyu
IPC分类号： A61M1/16
CPC分类号： A61M1/1696 , A61M1/16 , A61M1/3609 , A61M2205/15 , A61M2205/3313 , A61M2205/3317 , A61M2205/50 , A61M2205/75 , A61M2209/082 , A61M2230/65 , B01D15/00 , B01D15/02 , B01D2313/44 , B01J20/0211 , B01J20/0292 , B01J20/20 , B01J20/24 , B01J2220/62
摘要： Disclosed are systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, a sorbent cartridge with at least two separate flow paths, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.
摘要翻译： 公开了用于执行肾脏替代疗法的系统和方法，其具有或使用透析器，控制部件，具有至少两个分开的流动路径的吸附剂药筒，以及被配置为具有适于穿戴或携带的重量和尺寸的流体储存器 需要治疗的个体。 用于执行肾脏替代治疗的系统具有受控的依从性透析电路，其中控制泵控制流体穿过透析膜的双向运动。 透析电路和用于循环血液的体外循环通过透析膜流体连通。 在体外循环和透析回路之间移动的流体通量由控制泵运行的速率改变，从而可以控制超滤速率和对流间隙。 该系统提供对吸附剂盒的入口和出口导电性的监测，以提供量化或监测吸附剂盒去除尿素的设施。
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公开(公告)号：US20130213890A1
公开(公告)日：2013-08-22
申请号：US13586824
申请日：2012-08-15
申请人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
发明人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
IPC分类号： A61M1/16
CPC分类号： A61M1/16 , A61M1/1607 , A61M1/1609 , A61M1/1696 , A61M1/3609 , A61M1/3612 , A61M2205/15 , A61M2205/3317 , A61M2205/3324 , A61M2205/3334 , A61M2205/50 , A61M2230/207
摘要： Apparatuses, systems, and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. A first sorbent cartridge is provided for use in a portable treatment module having activated carbon and zirconium oxide. The system also provides for the monitoring of an inlet and outlet conductivity of a sorbent cartridge containing urease to provide a facility to quantify or monitor the removal of urea by a detachable urea removal module.
摘要翻译： 公开了用于执行肾脏替代疗法的装置，系统和方法，其具有或使用透析器，控制组件，吸附剂盒和流体储存器，其被配置为适于被需要治疗的个体穿戴或携带的重量和尺寸。 该系统具有受控的依从性透析电路，其中控制泵控制流体穿过透析膜的双向运动。 第一吸附剂盒被提供用于具有活性炭和氧化锆的便携式处理组件中。 该系统还提供用于监测含有脲酶的吸附剂盒的入口和出口电导率，以提供通过可拆卸的尿素去除模块量化或监测尿素去除的设施。
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公开(公告)号：US08795217B2
公开(公告)日：2014-08-05
申请号：US13413168
申请日：2012-03-06
申请人： Rodolfo Roger , Robert Childers , Thomas D. Kelly
发明人： Rodolfo Roger , Robert Childers , Thomas D. Kelly
IPC分类号： A61M37/00
CPC分类号： A61M1/3656 , A61M1/14 , A61M1/3607 , A61M1/3639 , A61M1/3653 , A61M2205/058 , A61M2205/15 , A61M2205/3306 , A61M2205/3317 , A61M2205/3331 , A61M2205/3344 , A61M2205/3375 , A61M2205/3569 , A61M2205/3592 , A61M2230/04
摘要： An access disconnection system includes: an arterial line; a venous line; a transmitter configured to transmit a sound wave in one of the arterial and venous lines when connected to a patient; a receiver configured to receive the sound wave from the other of the arterial and venous lines when connected to the patient; and electronic circuitry coupled to at least one of the transmitter and receiver, the circuitry configured to send a disconnection output indicative of a change in the sound waves received by the receiver from the transmitter sufficient to expect that an access disconnection of one of the arterial line and venous lines has occurred.
摘要翻译： 一种接入断开系统包括：一条主干线; 静脉线 发射器，其被配置为当连接到患者时在其中一个动脉和静脉线中传输声波; 接收器，被配置为当连接到患者时从另一个动脉和静脉线接收声波; 以及耦合到所述发射机和接收机中的至少一个的电子电路，所述电路被配置为发送指示所述接收机从所述发射机接收的声波的变化的断开输出，足以预期所述动脉线之一的接入断开 并发生静脉线。
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公开(公告)号：US08496809B2
公开(公告)日：2013-07-30
申请号：US11422267
申请日：2006-06-05
CPC分类号： A61M1/16 , A61M1/14 , A61M1/1605 , A61M1/1613 , A61M1/28 , A61M1/284 , A61M1/341 , A61M2205/3334 , A61M2205/3393
摘要： A kidney failure treatment system includes: (i) a dialysate supply; (ii) a weighing device; a control container coupled operably to the weighing device; (iii) a diffusion membrane; (iv) a drain; first and second pumps; (v) a first fluid conduit coupled fluidly to the dialysate supply and the diffusion membrane, the first fluid conduit coupled operably to the first pump; (vi) a second fluid conduit coupled fluidly to the control container and the drain, the second fluid conduit coupled operably to the first pump; and (vii) a third fluid conduit coupled fluidly to the diffusion membrane and the control conduit, the third fluid conduit coupled operably to the second pump.
摘要翻译： 肾衰竭治疗系统包括：（i）透析液供应; （ii）称重装置; 可操作地联接到称重装置的控制容器; （iii）扩散膜; （iv）排水; 第一和第二泵; （v）流体地连接到透析液供应器和扩散膜的第一流体导管，第一流体导管可操作地连接到第一泵; （vi）流体地连接到所述控制容器和所述排水口的第二流体管道，所述第二流体管道可操作地连接到所述第一泵; 和（vii）流体地连接到扩散膜和控制管道的第三流体管道，第三流体管道可操作地连接到第二泵。
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10.发明授权Renal therapy blood cleansing system with balance chamber and bolus, rinseback or prime volume feature 有权肾脏治疗血液清洁系统，平衡室和推注，冲洗或主体积特征公开(公告)号：US08430835B2
公开(公告)日：2013-04-30
申请号：US12793906
申请日：2010-06-04
CPC分类号： A61M1/3462 , A61M1/1601 , A61M1/1635 , A61M1/1672 , A61M1/30 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M1/3413 , A61M1/3434 , A61M1/3437 , A61M1/3643 , A61M1/3644 , A61M1/3647 , A61M1/3649 , A61M2205/3303 , A61M2205/3306 , A61M2205/50 , A61M2205/7518
摘要： A renal therapy blood cleaning system includes: a blood filtering device in communication with an extracorporeal circuit; a first pump configured to pump fluid to the blood filtering device; a second pump configured to pump fluid from the blood filtering device; a balance chamber in fluid communication with first and second lines, the first and second lines in fluid communication with the first and second pumps, respectively, the balance chamber configured to exchange like volumes of fresh and spent fluid; a plurality of valves; and a control scheme programmed to operate the plurality of valves to enable spent fluid taken from the balancing chamber through one of the first and second lines to be recirculated to the balance chamber through the other of the first and second lines to compensate for a volume of fresh fluid delivered to the blood filtering device.
摘要翻译： 一种肾脏治疗血液净化系统，包括：与体外循环连通的血液过滤装置; 构造成将流体泵送到血液过滤装置的第一泵; 构造成从血液过滤装置泵送流体的第二泵; 与第一和第二管线流体连通的平衡腔室，分别与第一和第二泵流体连通的第一和第二管路，所述平衡腔室配置成相互交换体积的新鲜和废液体; 多个阀门; 以及控制方案，其被编程为操作所述多个阀，以使通过所述第一和第二管线之一从所述平衡室取出的废流通过所述第一和第二管线中的另一条再循环到所述平衡室，以补偿 新鲜流体输送到血液过滤装置。
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